A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver

A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver

SUMO-modification of nuclear proteins has profound effects on gene expression. However, non-toxic chemical tools that modulate sumoylation in cells are lacking. Here, to identify small molecule sumoylation inhibitors we developed a cell-based screen that focused on the well-sumoylated substrate, hum...

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Bibliographic Details
Main Authors: Miyuki Suzawa, Diego A Miranda, Karmela A Ramos, Kenny K-H Ang, Emily J Faivre, Christopher G Wilson, Laura Caboni, Michelle R Arkin, Yeong-Sang Kim, Robert J Fletterick, Aaron Diaz, John S Schneekloth Jr, Holly A Ingraham
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-12-01
Series:eLife
Subjects:
sumoylation
phenotypic screen
NR5As
tannic acid
primary hepatocytes
NASH
Online Access:https://elifesciences.org/articles/09003

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