Memory markers in the continuum of the Alzheimer’s clinical syndrome
Abstract Background The individual and complementary value of the Visual Short-Term Memory Binding Test (VSTMBT) and the Free and Cued Selective Reminding Test (FCSRT) as markers to trace the AD continuum was investigated. It was hypothesised that the VSTMBT would be an early indicator while the FCS...
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | Alzheimer’s Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13195-022-01082-9 |
| _version_ | 1811201255805026304 |
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| author | Mario A. Parra Clara Calia Vivek Pattan Sergio Della Sala |
| author_facet | Mario A. Parra Clara Calia Vivek Pattan Sergio Della Sala |
| author_sort | Mario A. Parra |
| collection | DOAJ |
| description | Abstract Background The individual and complementary value of the Visual Short-Term Memory Binding Test (VSTMBT) and the Free and Cued Selective Reminding Test (FCSRT) as markers to trace the AD continuum was investigated. It was hypothesised that the VSTMBT would be an early indicator while the FCSRT would inform on imminent progression. Methods Healthy older adults (n=70) and patients with mild cognitive impairment (MCI) (n=80) were recruited and followed up between 2012 and 2017. Participants with at least two assessment points entered the study. Using baseline and follow-up assessments four groups were defined: Older adults who were healthy (HOA), with very mild cognitive but not functional impairment (eMCI), and with MCI who did and did not convert to dementia (MCI converters and non-converters). Results Only the VSTMBT predicted group membership in the very early stages (HOA vs eMCI). As the disease progressed, the FCSRT became a strong predictor excluding the VSTMB from the models. Their complementary value was high during the mid-prodromal stages and decreased in stages closer to dementia. Discussion The study supports the notion that neuropsychological assessment for AD needs to abandon the notion of one-size-fits-all. A memory toolkit for AD needs to consider tools that are early indicators and tools that suggest imminent progression. The VSTMBT and the FSCRT are such tools. |
| first_indexed | 2024-04-12T02:18:12Z |
| format | Article |
| id | doaj.art-7fce4b2d60ec4db9ae0e4ee441c3edd0 |
| institution | Directory Open Access Journal |
| issn | 1758-9193 |
| language | English |
| last_indexed | 2024-04-12T02:18:12Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Alzheimer’s Research & Therapy |
| spelling | doaj.art-7fce4b2d60ec4db9ae0e4ee441c3edd02022-12-22T03:52:12ZengBMCAlzheimer’s Research & Therapy1758-91932022-09-0114111610.1186/s13195-022-01082-9Memory markers in the continuum of the Alzheimer’s clinical syndromeMario A. Parra0Clara Calia1Vivek Pattan2Sergio Della Sala3School of Psychological Sciences and Health, University of StrathclydeSchool of Health in Social Science, University of EdinburghNHS Forth Valley, Stirling Community HospitalHuman Cognitive Neuroscience, Psychology Department, University of EdinburghAbstract Background The individual and complementary value of the Visual Short-Term Memory Binding Test (VSTMBT) and the Free and Cued Selective Reminding Test (FCSRT) as markers to trace the AD continuum was investigated. It was hypothesised that the VSTMBT would be an early indicator while the FCSRT would inform on imminent progression. Methods Healthy older adults (n=70) and patients with mild cognitive impairment (MCI) (n=80) were recruited and followed up between 2012 and 2017. Participants with at least two assessment points entered the study. Using baseline and follow-up assessments four groups were defined: Older adults who were healthy (HOA), with very mild cognitive but not functional impairment (eMCI), and with MCI who did and did not convert to dementia (MCI converters and non-converters). Results Only the VSTMBT predicted group membership in the very early stages (HOA vs eMCI). As the disease progressed, the FCSRT became a strong predictor excluding the VSTMB from the models. Their complementary value was high during the mid-prodromal stages and decreased in stages closer to dementia. Discussion The study supports the notion that neuropsychological assessment for AD needs to abandon the notion of one-size-fits-all. A memory toolkit for AD needs to consider tools that are early indicators and tools that suggest imminent progression. The VSTMBT and the FSCRT are such tools.https://doi.org/10.1186/s13195-022-01082-9Visual Short-Term Memory BindingAlzheimer’s diseaseNeuropsychological assessmentEarly detection |
| spellingShingle | Mario A. Parra Clara Calia Vivek Pattan Sergio Della Sala Memory markers in the continuum of the Alzheimer’s clinical syndrome Alzheimer’s Research & Therapy Visual Short-Term Memory Binding Alzheimer’s disease Neuropsychological assessment Early detection |
| title | Memory markers in the continuum of the Alzheimer’s clinical syndrome |
| title_full | Memory markers in the continuum of the Alzheimer’s clinical syndrome |
| title_fullStr | Memory markers in the continuum of the Alzheimer’s clinical syndrome |
| title_full_unstemmed | Memory markers in the continuum of the Alzheimer’s clinical syndrome |
| title_short | Memory markers in the continuum of the Alzheimer’s clinical syndrome |
| title_sort | memory markers in the continuum of the alzheimer s clinical syndrome |
| topic | Visual Short-Term Memory Binding Alzheimer’s disease Neuropsychological assessment Early detection |
| url | https://doi.org/10.1186/s13195-022-01082-9 |
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