Incidence, risk factors and outcomes of acute kidney injury among COVID-19 patients: A systematic review of systematic reviews
The COVID-19 associated acute kidney injury (CAKI) has emerged as a potential intricacy during the management of patients. Navigating the rapidly growing body of scientific literature on CAKI is challenging, and ongoing critical appraisal of this complication is essential. This study aimed to summar...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.973030/full |
| _version_ | 1798044787556745216 |
|---|---|
| author | Tauqeer Hussain Mallhi Yusra Habib Khan Yusra Habib Khan Abdulaziz Ibrahim Alzarea Faiz Ullah Khan Nasser Hadal Alotaibi Abdullah Salah Alanazi Abdullah Salah Alanazi Muhammad Hammad Butt Ahmed D. Alatawi Muhammad Salman Sami I. Alzarea Ziyad Saeed Almalki Mansoor A. Alghazi Majed Ahmed Algarni |
| author_facet | Tauqeer Hussain Mallhi Yusra Habib Khan Yusra Habib Khan Abdulaziz Ibrahim Alzarea Faiz Ullah Khan Nasser Hadal Alotaibi Abdullah Salah Alanazi Abdullah Salah Alanazi Muhammad Hammad Butt Ahmed D. Alatawi Muhammad Salman Sami I. Alzarea Ziyad Saeed Almalki Mansoor A. Alghazi Majed Ahmed Algarni |
| author_sort | Tauqeer Hussain Mallhi |
| collection | DOAJ |
| description | The COVID-19 associated acute kidney injury (CAKI) has emerged as a potential intricacy during the management of patients. Navigating the rapidly growing body of scientific literature on CAKI is challenging, and ongoing critical appraisal of this complication is essential. This study aimed to summarize and critically appraise the systematic reviews (SRs) on CAKI to inform the healthcare providers about its prevalence, risk factors and outcomes. All the SRs were searched in major databases (PubMed, EMBASE, Web of Science) from inception date to December 2021. This study followed SR of SRs methodology, all the records were screened, extracted and subjected to quality assessment by assessing the methodological quality of systematic reviews (AMSTAR-2). The extracted data were qualitatively synthesized and tabulated. This review protocol was registered in PROSPERO (CRD42022299444). Of 3,833 records identified; 42 SRs were included in this overview. The quality appraisal of the studies showed that 17 SRs were of low quality, while 8 moderate and 17 were of high-quality SRs. The incidence of CAKI ranged from 4.3% to 36.4% in overall COVID-19 patients, 36%–50% in kidney transplant recipients (KTRs), and up to 53% in severe or critical illness. Old age, male gender, cardiovascular disease, chronic kidney disease, diabetes mellitus and hypertension were frequently reported risk factors of CAKI. The need of renal replacement therapy (RRT) was up to 26.4% in overall COVID-19 patients, and 39% among those having CAKI. The occurrence of acute kidney injury (AKI) was found independent predictor of death, where mortality rate among CAKI patients ranged from 50% to 93%. This overview of SRs underscores that CAKI occurs frequently among COVID-19 patients and associated with high mortality, need of RRT and adverse outcomes. However, the confidence of these results is moderate to low which warrants the need of more SRs having established methodological standards.Systematic review registration[https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=299444], identifier [CRD42022299444]. |
| first_indexed | 2024-04-11T23:09:56Z |
| format | Article |
| id | doaj.art-7fcfdd14c97e4088981d56d584e96ff6 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-11T23:09:56Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-7fcfdd14c97e4088981d56d584e96ff62022-12-22T03:57:53ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-11-01910.3389/fmed.2022.973030973030Incidence, risk factors and outcomes of acute kidney injury among COVID-19 patients: A systematic review of systematic reviewsTauqeer Hussain Mallhi0Yusra Habib Khan1Yusra Habib Khan2Abdulaziz Ibrahim Alzarea3Faiz Ullah Khan4Nasser Hadal Alotaibi5Abdullah Salah Alanazi6Abdullah Salah Alanazi7Muhammad Hammad Butt8Ahmed D. Alatawi9Muhammad Salman10Sami I. Alzarea11Ziyad Saeed Almalki12Mansoor A. Alghazi13Majed Ahmed Algarni14Department of Clinical Pharmacy, College of Pharmacy, Jouf University, Sakaka, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, Jouf University, Sakaka, Saudi ArabiaHealth Sciences Research Unit, Jouf University, Sakaka, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, Jouf University, Sakaka, Saudi ArabiaDepartment of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Xi’an Jiaotong University, Xi’an, ChinaDepartment of Clinical Pharmacy, College of Pharmacy, Jouf University, Sakaka, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, Jouf University, Sakaka, Saudi ArabiaHealth Sciences Research Unit, Jouf University, Sakaka, Saudi ArabiaDepartment of Medicinal Chemistry, Faculty of Pharmacy, Uppsala University, Uppsala, SwedenDepartment of Clinical Pharmacy, College of Pharmacy, Jouf University, Sakaka, Saudi ArabiaInstitute of Pharmacy, Faculty of Pharmaceutical and Allied Health Sciences, Lahore College for Women University, Lahore, PakistanDepartment of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi ArabiaDepartment of Pharmaceutical Care, King Abdulaziz Medical City, Riyadh, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, Taif University, Taif, Saudi ArabiaThe COVID-19 associated acute kidney injury (CAKI) has emerged as a potential intricacy during the management of patients. Navigating the rapidly growing body of scientific literature on CAKI is challenging, and ongoing critical appraisal of this complication is essential. This study aimed to summarize and critically appraise the systematic reviews (SRs) on CAKI to inform the healthcare providers about its prevalence, risk factors and outcomes. All the SRs were searched in major databases (PubMed, EMBASE, Web of Science) from inception date to December 2021. This study followed SR of SRs methodology, all the records were screened, extracted and subjected to quality assessment by assessing the methodological quality of systematic reviews (AMSTAR-2). The extracted data were qualitatively synthesized and tabulated. This review protocol was registered in PROSPERO (CRD42022299444). Of 3,833 records identified; 42 SRs were included in this overview. The quality appraisal of the studies showed that 17 SRs were of low quality, while 8 moderate and 17 were of high-quality SRs. The incidence of CAKI ranged from 4.3% to 36.4% in overall COVID-19 patients, 36%–50% in kidney transplant recipients (KTRs), and up to 53% in severe or critical illness. Old age, male gender, cardiovascular disease, chronic kidney disease, diabetes mellitus and hypertension were frequently reported risk factors of CAKI. The need of renal replacement therapy (RRT) was up to 26.4% in overall COVID-19 patients, and 39% among those having CAKI. The occurrence of acute kidney injury (AKI) was found independent predictor of death, where mortality rate among CAKI patients ranged from 50% to 93%. This overview of SRs underscores that CAKI occurs frequently among COVID-19 patients and associated with high mortality, need of RRT and adverse outcomes. However, the confidence of these results is moderate to low which warrants the need of more SRs having established methodological standards.Systematic review registration[https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=299444], identifier [CRD42022299444].https://www.frontiersin.org/articles/10.3389/fmed.2022.973030/fullCOVID-19SARS-CoV-2coronavirusacute kidney injurycomplicationsmortality |
| spellingShingle | Tauqeer Hussain Mallhi Yusra Habib Khan Yusra Habib Khan Abdulaziz Ibrahim Alzarea Faiz Ullah Khan Nasser Hadal Alotaibi Abdullah Salah Alanazi Abdullah Salah Alanazi Muhammad Hammad Butt Ahmed D. Alatawi Muhammad Salman Sami I. Alzarea Ziyad Saeed Almalki Mansoor A. Alghazi Majed Ahmed Algarni Incidence, risk factors and outcomes of acute kidney injury among COVID-19 patients: A systematic review of systematic reviews Frontiers in Medicine COVID-19 SARS-CoV-2 coronavirus acute kidney injury complications mortality |
| title | Incidence, risk factors and outcomes of acute kidney injury among COVID-19 patients: A systematic review of systematic reviews |
| title_full | Incidence, risk factors and outcomes of acute kidney injury among COVID-19 patients: A systematic review of systematic reviews |
| title_fullStr | Incidence, risk factors and outcomes of acute kidney injury among COVID-19 patients: A systematic review of systematic reviews |
| title_full_unstemmed | Incidence, risk factors and outcomes of acute kidney injury among COVID-19 patients: A systematic review of systematic reviews |
| title_short | Incidence, risk factors and outcomes of acute kidney injury among COVID-19 patients: A systematic review of systematic reviews |
| title_sort | incidence risk factors and outcomes of acute kidney injury among covid 19 patients a systematic review of systematic reviews |
| topic | COVID-19 SARS-CoV-2 coronavirus acute kidney injury complications mortality |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.973030/full |
| work_keys_str_mv | AT tauqeerhussainmallhi incidenceriskfactorsandoutcomesofacutekidneyinjuryamongcovid19patientsasystematicreviewofsystematicreviews AT yusrahabibkhan incidenceriskfactorsandoutcomesofacutekidneyinjuryamongcovid19patientsasystematicreviewofsystematicreviews AT yusrahabibkhan incidenceriskfactorsandoutcomesofacutekidneyinjuryamongcovid19patientsasystematicreviewofsystematicreviews AT abdulazizibrahimalzarea incidenceriskfactorsandoutcomesofacutekidneyinjuryamongcovid19patientsasystematicreviewofsystematicreviews AT faizullahkhan incidenceriskfactorsandoutcomesofacutekidneyinjuryamongcovid19patientsasystematicreviewofsystematicreviews AT nasserhadalalotaibi incidenceriskfactorsandoutcomesofacutekidneyinjuryamongcovid19patientsasystematicreviewofsystematicreviews AT abdullahsalahalanazi incidenceriskfactorsandoutcomesofacutekidneyinjuryamongcovid19patientsasystematicreviewofsystematicreviews AT abdullahsalahalanazi incidenceriskfactorsandoutcomesofacutekidneyinjuryamongcovid19patientsasystematicreviewofsystematicreviews AT muhammadhammadbutt incidenceriskfactorsandoutcomesofacutekidneyinjuryamongcovid19patientsasystematicreviewofsystematicreviews AT ahmeddalatawi incidenceriskfactorsandoutcomesofacutekidneyinjuryamongcovid19patientsasystematicreviewofsystematicreviews AT muhammadsalman incidenceriskfactorsandoutcomesofacutekidneyinjuryamongcovid19patientsasystematicreviewofsystematicreviews AT samiialzarea incidenceriskfactorsandoutcomesofacutekidneyinjuryamongcovid19patientsasystematicreviewofsystematicreviews AT ziyadsaeedalmalki incidenceriskfactorsandoutcomesofacutekidneyinjuryamongcovid19patientsasystematicreviewofsystematicreviews AT mansooraalghazi incidenceriskfactorsandoutcomesofacutekidneyinjuryamongcovid19patientsasystematicreviewofsystematicreviews AT majedahmedalgarni incidenceriskfactorsandoutcomesofacutekidneyinjuryamongcovid19patientsasystematicreviewofsystematicreviews |