Predisposing factors to premature coronary artery disease in young (age ≤ 45 years) smokers: A single center retrospective case control study from India
Introduction: The role of the conventional risk factors in premature coronary artery disease (CAD) after eliminating the confounding variability of smoking has not been evaluated. This study was conducted to identify role of traditional risk factors in smokers with premature CAD.Methods: The case re...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2014-03-01
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| Series: | Journal of Cardiovascular and Thoracic Research |
| Subjects: | |
| Online Access: | http://journals.tbzmed.ac.ir/JCVTR/PDF/JCVTR-6-15.pdf |
| _version_ | 1818238777690161152 |
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| author | Amitesh Aggarwal Sourabh Aggarwal Prattaya Guha Sarkar Vishal Sharma |
| author_facet | Amitesh Aggarwal Sourabh Aggarwal Prattaya Guha Sarkar Vishal Sharma |
| author_sort | Amitesh Aggarwal |
| collection | DOAJ |
| description | Introduction: The role of the conventional risk factors in premature coronary artery disease (CAD) after eliminating the confounding variability of smoking has not been evaluated. This study was conducted to identify role of traditional risk factors in smokers with premature CAD.Methods: The case records of patients presenting acutely with premature CAD during the period 2007-2010 were analyzed retrospectively. Age, sex and smoking matched controls were selected from same time period. Data records were obtained for family history, alcohol, waist size, blood pressure, hypertension, blood sugar, lipid profile and presence of cutaneous markers for both groups and analyzed using statistical software.Results: 234 smokers with CAD and 122 smokers without CAD were included in groups 1 and 2, respectively. The patients in group 1 had significantly increased prevalence of hypertension, diabetes mellitus, metabolic syndrome, dyslipidemia and central obesity. There was no difference in prevalence of family history of CAD, arcus juvenilis and baldness. We found statistically significant association of hypertension, DM and metabolic syndrome in young smokers with premature acute CAD in Indian population as compared to young smokers without CAD.Conclusion: In young smokers, presence of hypertension, central obesity, diabetes mellitus and metabolic syndrome identifies a subset at increased risk for future acute CAD requiring more rigorous follow up and treatment. |
| first_indexed | 2024-12-12T12:47:03Z |
| format | Article |
| id | doaj.art-7fd222c2109b4774bda7ac2a5c6ae80d |
| institution | Directory Open Access Journal |
| issn | 2008-5117 2008-6830 |
| language | English |
| last_indexed | 2024-12-12T12:47:03Z |
| publishDate | 2014-03-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Journal of Cardiovascular and Thoracic Research |
| spelling | doaj.art-7fd222c2109b4774bda7ac2a5c6ae80d2022-12-22T00:24:05ZengTabriz University of Medical SciencesJournal of Cardiovascular and Thoracic Research2008-51172008-68302014-03-0161151910.5681/jcvtr.2014.003JCVTR_549_20140318112215Predisposing factors to premature coronary artery disease in young (age ≤ 45 years) smokers: A single center retrospective case control study from IndiaAmitesh Aggarwal0Sourabh Aggarwal1Prattaya Guha Sarkar2Vishal Sharma3Department of Medicine, University College of Medical Sciences (University of Delhi) and GTB Hospital, Delhi, IndiaDepartment of Medicine, University College of Medical Sciences (University of Delhi) and GTB Hospital, Delhi, IndiaDepartment of Medicine, University College of Medical Sciences (University of Delhi) and GTB Hospital, Delhi, IndiaDepartment of Medicine, University College of Medical Sciences (University of Delhi) and GTB Hospital, Delhi, IndiaIntroduction: The role of the conventional risk factors in premature coronary artery disease (CAD) after eliminating the confounding variability of smoking has not been evaluated. This study was conducted to identify role of traditional risk factors in smokers with premature CAD.Methods: The case records of patients presenting acutely with premature CAD during the period 2007-2010 were analyzed retrospectively. Age, sex and smoking matched controls were selected from same time period. Data records were obtained for family history, alcohol, waist size, blood pressure, hypertension, blood sugar, lipid profile and presence of cutaneous markers for both groups and analyzed using statistical software.Results: 234 smokers with CAD and 122 smokers without CAD were included in groups 1 and 2, respectively. The patients in group 1 had significantly increased prevalence of hypertension, diabetes mellitus, metabolic syndrome, dyslipidemia and central obesity. There was no difference in prevalence of family history of CAD, arcus juvenilis and baldness. We found statistically significant association of hypertension, DM and metabolic syndrome in young smokers with premature acute CAD in Indian population as compared to young smokers without CAD.Conclusion: In young smokers, presence of hypertension, central obesity, diabetes mellitus and metabolic syndrome identifies a subset at increased risk for future acute CAD requiring more rigorous follow up and treatment.http://journals.tbzmed.ac.ir/JCVTR/PDF/JCVTR-6-15.pdfCoronary Artery DiseaseYoungSmokingDyslipidemiaDiabetesHypertension |
| spellingShingle | Amitesh Aggarwal Sourabh Aggarwal Prattaya Guha Sarkar Vishal Sharma Predisposing factors to premature coronary artery disease in young (age ≤ 45 years) smokers: A single center retrospective case control study from India Journal of Cardiovascular and Thoracic Research Coronary Artery Disease Young Smoking Dyslipidemia Diabetes Hypertension |
| title | Predisposing factors to premature coronary artery
disease in young (age ≤ 45 years) smokers: A single center retrospective case
control study from India |
| title_full | Predisposing factors to premature coronary artery
disease in young (age ≤ 45 years) smokers: A single center retrospective case
control study from India |
| title_fullStr | Predisposing factors to premature coronary artery
disease in young (age ≤ 45 years) smokers: A single center retrospective case
control study from India |
| title_full_unstemmed | Predisposing factors to premature coronary artery
disease in young (age ≤ 45 years) smokers: A single center retrospective case
control study from India |
| title_short | Predisposing factors to premature coronary artery
disease in young (age ≤ 45 years) smokers: A single center retrospective case
control study from India |
| title_sort | predisposing factors to premature coronary artery disease in young age ≤ 45 years smokers a single center retrospective case control study from india |
| topic | Coronary Artery Disease Young Smoking Dyslipidemia Diabetes Hypertension |
| url | http://journals.tbzmed.ac.ir/JCVTR/PDF/JCVTR-6-15.pdf |
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