Blunted sFasL signalling exacerbates TNF‐driven neutrophil necroptosis in critically ill COVID‐19 patients

Blunted sFasL signalling exacerbates TNF‐driven neutrophil necroptosis in critically ill COVID‐19 patients

Abstract Objectives Critically ill coronavirus disease 2019 (COVID‐19) patients are characterised by a severely dysregulated cytokine profile and elevated neutrophil counts, impacting disease severity. However, it remains unclear how neutrophils contribute to pathophysiology during COVID‐19. Here, w...

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Bibliographic Details
Main Authors: Tiziano A Schweizer, Srikanth Mairpady Shambat, Clement Vulin, Sylvia Hoeller, Claudio Acevedo, Markus Huemer, Alejandro Gomez‐Mejia, Chun‐Chi Chang, Jeruscha Baum, Sanne Hertegonne, Eva Hitz, Thomas C Scheier, Daniel A Hofmaenner, Philipp K Buehler, Holger Moch, Reto A Schuepbach, Silvio D Brugger, Annelies S Zinkernagel
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Clinical & Translational Immunology
Subjects:
COVID‐19
Fas (CD95)
necroptosis
neutrophils
RIPK1
TNF‐α
Online Access:https://doi.org/10.1002/cti2.1357

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