Primary breast non-Hodgkin’s lymphoma in a 14-year-old girl: a case report
Abstract Background Primary breast lymphoma is rare. Occurrence rates of malignant breast tumors in children are also quite low. We herein report a B-lymphoblastic lymphoma of the breast arisen in an adolescent girl. To the best of our knowledge, this is the youngest case with primary breast non-Hod...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-04-01
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| Series: | Surgical Case Reports |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40792-020-00850-9 |
| _version_ | 1818904473233260544 |
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| author | Yumiko Ishizuka Yoshiya Horimoto Junya Fujimura Kozue Ogata Fumi Murakami Hiroko Onagi Atsushi Arakawa Mitsue Saito |
| author_facet | Yumiko Ishizuka Yoshiya Horimoto Junya Fujimura Kozue Ogata Fumi Murakami Hiroko Onagi Atsushi Arakawa Mitsue Saito |
| author_sort | Yumiko Ishizuka |
| collection | DOAJ |
| description | Abstract Background Primary breast lymphoma is rare. Occurrence rates of malignant breast tumors in children are also quite low. We herein report a B-lymphoblastic lymphoma of the breast arisen in an adolescent girl. To the best of our knowledge, this is the youngest case with primary breast non-Hodgkin’s lymphoma. Case presentation A 14-year-old Japanese girl felt a lump in her right breast and came to our hospital. A circumscribed soft mass, 30 mm in diameter, was palpable. Histological examination revealed atypical lymphoid cells diffusely spreading into the breast tissue. Based on results of immunohistochemistry and flow cytometry, her disease was diagnosed as B-lymphoblastic lymphoma (stage I). She was then referred to the pediatric department and received combination chemotherapy, based on a chemotherapy regimen for children with acute lymphoblastic leukemia. Following remission induction therapy, we confirmed no FDG uptake in the right breast on PET-CT scan. Conclusions We have described a rare malignant lymphoma arising in the breast of an adolescent female. Histological assessment is necessary for diagnosis of breast lymphoma. However, it can be challenging with several reasons, and clinical information may contribute to the assessment. Moreover, treatments for lymphoma vary according to disease types. Thus, surgeons should collaborate closely with pathologists, pediatricians, and hematologists. |
| first_indexed | 2024-12-19T21:08:00Z |
| format | Article |
| id | doaj.art-7fd30499e3a44ca5a9fed1d61e113161 |
| institution | Directory Open Access Journal |
| issn | 2198-7793 |
| language | English |
| last_indexed | 2024-12-19T21:08:00Z |
| publishDate | 2020-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj.art-7fd30499e3a44ca5a9fed1d61e1131612022-12-21T20:05:36ZengSpringerOpenSurgical Case Reports2198-77932020-04-01611510.1186/s40792-020-00850-9Primary breast non-Hodgkin’s lymphoma in a 14-year-old girl: a case reportYumiko Ishizuka0Yoshiya Horimoto1Junya Fujimura2Kozue Ogata3Fumi Murakami4Hiroko Onagi5Atsushi Arakawa6Mitsue Saito7Department of Breast Oncology, Juntendo University School of MedicineDepartment of Breast Oncology, Juntendo University School of MedicineDepartment of Pediatrics, Juntendo University School of MedicineDepartment of Breast Oncology, Juntendo University School of MedicineDepartment of Breast Oncology, Juntendo University School of MedicineDepartment of Human Pathology, Juntendo University School of MedicineDepartment of Human Pathology, Juntendo University School of MedicineDepartment of Breast Oncology, Juntendo University School of MedicineAbstract Background Primary breast lymphoma is rare. Occurrence rates of malignant breast tumors in children are also quite low. We herein report a B-lymphoblastic lymphoma of the breast arisen in an adolescent girl. To the best of our knowledge, this is the youngest case with primary breast non-Hodgkin’s lymphoma. Case presentation A 14-year-old Japanese girl felt a lump in her right breast and came to our hospital. A circumscribed soft mass, 30 mm in diameter, was palpable. Histological examination revealed atypical lymphoid cells diffusely spreading into the breast tissue. Based on results of immunohistochemistry and flow cytometry, her disease was diagnosed as B-lymphoblastic lymphoma (stage I). She was then referred to the pediatric department and received combination chemotherapy, based on a chemotherapy regimen for children with acute lymphoblastic leukemia. Following remission induction therapy, we confirmed no FDG uptake in the right breast on PET-CT scan. Conclusions We have described a rare malignant lymphoma arising in the breast of an adolescent female. Histological assessment is necessary for diagnosis of breast lymphoma. However, it can be challenging with several reasons, and clinical information may contribute to the assessment. Moreover, treatments for lymphoma vary according to disease types. Thus, surgeons should collaborate closely with pathologists, pediatricians, and hematologists.http://link.springer.com/article/10.1186/s40792-020-00850-9Primary breast lymphomaB-lymphoblastic LymphomaChildrenSurgery |
| spellingShingle | Yumiko Ishizuka Yoshiya Horimoto Junya Fujimura Kozue Ogata Fumi Murakami Hiroko Onagi Atsushi Arakawa Mitsue Saito Primary breast non-Hodgkin’s lymphoma in a 14-year-old girl: a case report Surgical Case Reports Primary breast lymphoma B-lymphoblastic Lymphoma Children Surgery |
| title | Primary breast non-Hodgkin’s lymphoma in a 14-year-old girl: a case report |
| title_full | Primary breast non-Hodgkin’s lymphoma in a 14-year-old girl: a case report |
| title_fullStr | Primary breast non-Hodgkin’s lymphoma in a 14-year-old girl: a case report |
| title_full_unstemmed | Primary breast non-Hodgkin’s lymphoma in a 14-year-old girl: a case report |
| title_short | Primary breast non-Hodgkin’s lymphoma in a 14-year-old girl: a case report |
| title_sort | primary breast non hodgkin s lymphoma in a 14 year old girl a case report |
| topic | Primary breast lymphoma B-lymphoblastic Lymphoma Children Surgery |
| url | http://link.springer.com/article/10.1186/s40792-020-00850-9 |
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