Are severe forms of thyroid eye disease common in the indian population? Clinical characteristics of 136 patients from a tertiary eye care centre
Context: Considerable evidence of gender, ethnicity, thyroid dysfunction, and environmental factors including smoking influencing the development and progression of thyroid eye disease (TED). Settings and Design: Cross-sectional study of the clinical characteristics of 136 patients with TED who pres...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2023;volume=27;issue=1;spage=56;epage=61;aulast=Subramaniam |
| _version_ | 1797824314110640128 |
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| author | Dhakshini L Subramaniam Dayakar Yadalla Jayagayathri Rajagopalan |
| author_facet | Dhakshini L Subramaniam Dayakar Yadalla Jayagayathri Rajagopalan |
| author_sort | Dhakshini L Subramaniam |
| collection | DOAJ |
| description | Context: Considerable evidence of gender, ethnicity, thyroid dysfunction, and environmental factors including smoking influencing the development and progression of thyroid eye disease (TED). Settings and Design: Cross-sectional study of the clinical characteristics of 136 patients with TED who presented to the Orbit and Oculoplasty services at a tertiary eye care center in south India between October 2018 and June 2020. Results: Among the 136 patients (M: 61, F: 75), the mean age was 47.04 (SD ± 13.24) years. Hyperthyroid disease was present in 53%, hypothyroid disease in 40%, and 7.3% were euthyroid. Active disease was noted in 25% and inactive disease in 75% of patients. Active disease was present in 25% of hyperthyroid, 18.5% of hypothyroid, and 15% of euthyroid patients. Active TED showed statistically significant association toward development of greater severity of proptosis (P = 0.001), optic neuropathy (P = 0.004), and extraocular movement restriction (P < 0.001) as compared to inactive disease. Mild, moderate to severe, and sight-threatening TED was noted in 34.6%, 59.6%, and 6% of patients, respectively. Nine eyes had dysthyroid optic neuropathy, of which eight had either mild or no proptosis while one had moderate to severe proptosis. Conclusion: Prevalence of active as well as severe thyroid eye disease is common in our population. Recommendation for ophthalmological examination of patients even with milder disease especially when associated with decreased vision and signs of inflammation. Active disease is less common in euthyroid patients, thus necessitating maintaining the euthyroid status toward reducing disease activity and progression. |
| first_indexed | 2024-03-13T10:37:11Z |
| format | Article |
| id | doaj.art-7fd3a011635247a190ceeafeb9517fa7 |
| institution | Directory Open Access Journal |
| issn | 2230-8210 |
| language | English |
| last_indexed | 2024-03-13T10:37:11Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-7fd3a011635247a190ceeafeb9517fa72023-05-18T05:47:05ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102023-01-01271566110.4103/ijem.ijem_280_21Are severe forms of thyroid eye disease common in the indian population? Clinical characteristics of 136 patients from a tertiary eye care centreDhakshini L SubramaniamDayakar YadallaJayagayathri RajagopalanContext: Considerable evidence of gender, ethnicity, thyroid dysfunction, and environmental factors including smoking influencing the development and progression of thyroid eye disease (TED). Settings and Design: Cross-sectional study of the clinical characteristics of 136 patients with TED who presented to the Orbit and Oculoplasty services at a tertiary eye care center in south India between October 2018 and June 2020. Results: Among the 136 patients (M: 61, F: 75), the mean age was 47.04 (SD ± 13.24) years. Hyperthyroid disease was present in 53%, hypothyroid disease in 40%, and 7.3% were euthyroid. Active disease was noted in 25% and inactive disease in 75% of patients. Active disease was present in 25% of hyperthyroid, 18.5% of hypothyroid, and 15% of euthyroid patients. Active TED showed statistically significant association toward development of greater severity of proptosis (P = 0.001), optic neuropathy (P = 0.004), and extraocular movement restriction (P < 0.001) as compared to inactive disease. Mild, moderate to severe, and sight-threatening TED was noted in 34.6%, 59.6%, and 6% of patients, respectively. Nine eyes had dysthyroid optic neuropathy, of which eight had either mild or no proptosis while one had moderate to severe proptosis. Conclusion: Prevalence of active as well as severe thyroid eye disease is common in our population. Recommendation for ophthalmological examination of patients even with milder disease especially when associated with decreased vision and signs of inflammation. Active disease is less common in euthyroid patients, thus necessitating maintaining the euthyroid status toward reducing disease activity and progression.http://www.ijem.in/article.asp?issn=2230-8210;year=2023;volume=27;issue=1;spage=56;epage=61;aulast=Subramaniamclinical featuresclinical profilegraves' ophthalmopathythyroid-associated ophthalmopathythyroid-associated orbitopathythyroid eye disease |
| spellingShingle | Dhakshini L Subramaniam Dayakar Yadalla Jayagayathri Rajagopalan Are severe forms of thyroid eye disease common in the indian population? Clinical characteristics of 136 patients from a tertiary eye care centre Indian Journal of Endocrinology and Metabolism clinical features clinical profile graves' ophthalmopathy thyroid-associated ophthalmopathy thyroid-associated orbitopathy thyroid eye disease |
| title | Are severe forms of thyroid eye disease common in the indian population? Clinical characteristics of 136 patients from a tertiary eye care centre |
| title_full | Are severe forms of thyroid eye disease common in the indian population? Clinical characteristics of 136 patients from a tertiary eye care centre |
| title_fullStr | Are severe forms of thyroid eye disease common in the indian population? Clinical characteristics of 136 patients from a tertiary eye care centre |
| title_full_unstemmed | Are severe forms of thyroid eye disease common in the indian population? Clinical characteristics of 136 patients from a tertiary eye care centre |
| title_short | Are severe forms of thyroid eye disease common in the indian population? Clinical characteristics of 136 patients from a tertiary eye care centre |
| title_sort | are severe forms of thyroid eye disease common in the indian population clinical characteristics of 136 patients from a tertiary eye care centre |
| topic | clinical features clinical profile graves' ophthalmopathy thyroid-associated ophthalmopathy thyroid-associated orbitopathy thyroid eye disease |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2023;volume=27;issue=1;spage=56;epage=61;aulast=Subramaniam |
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