Targeting PI3K/Akt/mTOR signaling in rodent models of PMP22 gene-dosage diseases

Targeting PI3K/Akt/mTOR signaling in rodent models of PMP22 gene-dosage diseases

Abstract Haplo-insufficiency of the gene encoding the myelin protein PMP22 leads to focal myelin overgrowth in the peripheral nervous system and hereditary neuropathy with liability to pressure palsies (HNPP). Conversely, duplication of PMP22 causes Charcot-Marie-Tooth disease type 1A (CMT1A), chara...

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Bibliographic Details
Main Authors: Doris Krauter, Daniela Stausberg, Timon J Hartmann, Stefan Volkmann, Theresa Kungl, David A Rasche, Gesine Saher, Robert Fledrich, Ruth M Stassart, Klaus-Armin Nave, Sandra Goebbels, David Ewers, Michael W Sereda
Format: Article
Language:English
Published: Springer Nature 2024-02-01
Series:EMBO Molecular Medicine
Subjects:
Charcot–Marie–Tooth Neuropathies
Peripheral Myelin Protein of 22 kDa
Myelin
Schwann Cell
PI3K/Akt/mTOR Signaling
Online Access:https://doi.org/10.1038/s44321-023-00019-5

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