A case-control association study of <it>NRXN1 </it>polymorphisms with schizophrenia in Chinese Han population
<p>Abstract</p> <p>Background</p> <p>Recent research has implicated that mutations in the neurexin-1 (<it>NRXN1</it>) gene on chromosome 2p16.3 might play a role in schizophrenia, autism, and nicotine dependence. In order to explore the association of <it...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-04-01
|
| Series: | Behavioral and Brain Functions |
| Subjects: | |
| Online Access: | http://www.behavioralandbrainfunctions.com/content/7/1/7 |
| _version_ | 1818487533765394432 |
|---|---|
| author | Lu Tianlan Zhang Yanling Yang Yongfeng Yue Weihua Hu Xiaofeng Wang Lifang Ruan Yanyan Lv Luxian Zhang Dai |
| author_facet | Lu Tianlan Zhang Yanling Yang Yongfeng Yue Weihua Hu Xiaofeng Wang Lifang Ruan Yanyan Lv Luxian Zhang Dai |
| author_sort | Lu Tianlan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Recent research has implicated that mutations in the neurexin-1 (<it>NRXN1</it>) gene on chromosome 2p16.3 might play a role in schizophrenia, autism, and nicotine dependence. In order to explore the association of <it>NRXN1 </it>polymorphisms with schizophrenia, we made a case-control association study in Chinese Han population.</p> <p>Methods</p> <p>We examined six tag single nucleotide polymorphisms (SNPs) spanning 116.7 kb of <it>NRXN1 </it>in 768 schizophrenic patients and 738 healthy control subjects. The association of <it>NRXN1 </it>polymorphisms with schizophrenia and the age-at-onset of this disease were explored.</p> <p>Results</p> <p>Our results showed that four SNPs of <it>NRXN1 </it>gene were significantly associated with schizophrenia (rs10490168: G > A, <it>p </it>= 0.017; rs2024513: A > G, <it>p </it>= 0.006; rs13382584: T > C, <it>p </it>= 0.009; and rs1558852: G > A, <it>p </it>= 0.031). Furthermore, the association of SNP rs2024513 with schizophrenia remained significance after the Bonferroni correction. Haplotypes consisting of above six SNPs also showed significantly associated with schizophrenia (global chi-square = 14.725, <it>p </it>= 0.022). A protective haplotype AGTGCA remained associated with schizophrenia, even after 10,000 permutation tests (empirical <it>p</it>-value = 0.043). However, we did not find any association with age-at-onset of schizophrenia with <it>NRXN1 </it>polymorphisms.</p> <p>Conclusions</p> <p>Our findings suggest that <it>NRXN1 </it>might represent a major susceptibility gene for schizophrenia in Chinese Han population.</p> |
| first_indexed | 2024-12-10T16:38:56Z |
| format | Article |
| id | doaj.art-7fd639a9fa1a4502851f456e6553e0f8 |
| institution | Directory Open Access Journal |
| issn | 1744-9081 |
| language | English |
| last_indexed | 2024-12-10T16:38:56Z |
| publishDate | 2011-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Behavioral and Brain Functions |
| spelling | doaj.art-7fd639a9fa1a4502851f456e6553e0f82022-12-22T01:41:17ZengBMCBehavioral and Brain Functions1744-90812011-04-0171710.1186/1744-9081-7-7A case-control association study of <it>NRXN1 </it>polymorphisms with schizophrenia in Chinese Han populationLu TianlanZhang YanlingYang YongfengYue WeihuaHu XiaofengWang LifangRuan YanyanLv LuxianZhang Dai<p>Abstract</p> <p>Background</p> <p>Recent research has implicated that mutations in the neurexin-1 (<it>NRXN1</it>) gene on chromosome 2p16.3 might play a role in schizophrenia, autism, and nicotine dependence. In order to explore the association of <it>NRXN1 </it>polymorphisms with schizophrenia, we made a case-control association study in Chinese Han population.</p> <p>Methods</p> <p>We examined six tag single nucleotide polymorphisms (SNPs) spanning 116.7 kb of <it>NRXN1 </it>in 768 schizophrenic patients and 738 healthy control subjects. The association of <it>NRXN1 </it>polymorphisms with schizophrenia and the age-at-onset of this disease were explored.</p> <p>Results</p> <p>Our results showed that four SNPs of <it>NRXN1 </it>gene were significantly associated with schizophrenia (rs10490168: G > A, <it>p </it>= 0.017; rs2024513: A > G, <it>p </it>= 0.006; rs13382584: T > C, <it>p </it>= 0.009; and rs1558852: G > A, <it>p </it>= 0.031). Furthermore, the association of SNP rs2024513 with schizophrenia remained significance after the Bonferroni correction. Haplotypes consisting of above six SNPs also showed significantly associated with schizophrenia (global chi-square = 14.725, <it>p </it>= 0.022). A protective haplotype AGTGCA remained associated with schizophrenia, even after 10,000 permutation tests (empirical <it>p</it>-value = 0.043). However, we did not find any association with age-at-onset of schizophrenia with <it>NRXN1 </it>polymorphisms.</p> <p>Conclusions</p> <p>Our findings suggest that <it>NRXN1 </it>might represent a major susceptibility gene for schizophrenia in Chinese Han population.</p>http://www.behavioralandbrainfunctions.com/content/7/1/7SchizophreniaNeurexin-1 (NRXN1)Haplotypeage-at-onset |
| spellingShingle | Lu Tianlan Zhang Yanling Yang Yongfeng Yue Weihua Hu Xiaofeng Wang Lifang Ruan Yanyan Lv Luxian Zhang Dai A case-control association study of <it>NRXN1 </it>polymorphisms with schizophrenia in Chinese Han population Behavioral and Brain Functions Schizophrenia Neurexin-1 (NRXN1) Haplotype age-at-onset |
| title | A case-control association study of <it>NRXN1 </it>polymorphisms with schizophrenia in Chinese Han population |
| title_full | A case-control association study of <it>NRXN1 </it>polymorphisms with schizophrenia in Chinese Han population |
| title_fullStr | A case-control association study of <it>NRXN1 </it>polymorphisms with schizophrenia in Chinese Han population |
| title_full_unstemmed | A case-control association study of <it>NRXN1 </it>polymorphisms with schizophrenia in Chinese Han population |
| title_short | A case-control association study of <it>NRXN1 </it>polymorphisms with schizophrenia in Chinese Han population |
| title_sort | case control association study of it nrxn1 it polymorphisms with schizophrenia in chinese han population |
| topic | Schizophrenia Neurexin-1 (NRXN1) Haplotype age-at-onset |
| url | http://www.behavioralandbrainfunctions.com/content/7/1/7 |
| work_keys_str_mv | AT lutianlan acasecontrolassociationstudyofitnrxn1itpolymorphismswithschizophreniainchinesehanpopulation AT zhangyanling acasecontrolassociationstudyofitnrxn1itpolymorphismswithschizophreniainchinesehanpopulation AT yangyongfeng acasecontrolassociationstudyofitnrxn1itpolymorphismswithschizophreniainchinesehanpopulation AT yueweihua acasecontrolassociationstudyofitnrxn1itpolymorphismswithschizophreniainchinesehanpopulation AT huxiaofeng acasecontrolassociationstudyofitnrxn1itpolymorphismswithschizophreniainchinesehanpopulation AT wanglifang acasecontrolassociationstudyofitnrxn1itpolymorphismswithschizophreniainchinesehanpopulation AT ruanyanyan acasecontrolassociationstudyofitnrxn1itpolymorphismswithschizophreniainchinesehanpopulation AT lvluxian acasecontrolassociationstudyofitnrxn1itpolymorphismswithschizophreniainchinesehanpopulation AT zhangdai acasecontrolassociationstudyofitnrxn1itpolymorphismswithschizophreniainchinesehanpopulation AT lutianlan casecontrolassociationstudyofitnrxn1itpolymorphismswithschizophreniainchinesehanpopulation AT zhangyanling casecontrolassociationstudyofitnrxn1itpolymorphismswithschizophreniainchinesehanpopulation AT yangyongfeng casecontrolassociationstudyofitnrxn1itpolymorphismswithschizophreniainchinesehanpopulation AT yueweihua casecontrolassociationstudyofitnrxn1itpolymorphismswithschizophreniainchinesehanpopulation AT huxiaofeng casecontrolassociationstudyofitnrxn1itpolymorphismswithschizophreniainchinesehanpopulation AT wanglifang casecontrolassociationstudyofitnrxn1itpolymorphismswithschizophreniainchinesehanpopulation AT ruanyanyan casecontrolassociationstudyofitnrxn1itpolymorphismswithschizophreniainchinesehanpopulation AT lvluxian casecontrolassociationstudyofitnrxn1itpolymorphismswithschizophreniainchinesehanpopulation AT zhangdai casecontrolassociationstudyofitnrxn1itpolymorphismswithschizophreniainchinesehanpopulation |