QTc prolongation in methadone maintenance – the role of HCV infection
OBJECTIVES: Several studies have reported prolonged QTc intervals in patients under methadone maintenance treatment, including development of torsade-de-pointes arrhythmia and death. It is still not clear why some patients develop critical QTc extensions while others do not. METHODS...
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| Format: | Article |
| Language: | English |
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SMW supporting association (Trägerverein Swiss Medical Weekly SMW)
2013-08-01
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| Series: | Swiss Medical Weekly |
| Subjects: | |
| Online Access: | https://www.smw.ch/index.php/smw/article/view/1743 |
| _version_ | 1826995902434246656 |
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| author | Najibulah Gholami Lukas Boesch Luis Falcato Rudolf Stohler Philip Bruggmann |
| author_facet | Najibulah Gholami Lukas Boesch Luis Falcato Rudolf Stohler Philip Bruggmann |
| author_sort | Najibulah Gholami |
| collection | DOAJ |
| description |
OBJECTIVES: Several studies have reported prolonged QTc intervals in patients under methadone maintenance treatment, including development of torsade-de-pointes arrhythmia and death. It is still not clear why some patients develop critical QTc extensions while others do not.
METHODS: ECG findings in a convenience sample of 210 methadone-maintained heroin-dependent patients, taking HCV-infection status and methadone dosage into account simultaneously by means of a multiple linear regression model with QTc-interval as the dependent variable.
RESULTS: Prolonged QTc-time is associated with hepatitis C infections (p = 0.005) and higher doses of racemic methadone (p = 0.012).
CONCLUSION: Infection with hepatitis C increases the likelihood of critical QTc prolongation in patients in methadone maintenance treatment.
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| first_indexed | 2024-04-13T03:37:31Z |
| format | Article |
| id | doaj.art-7fd64be8ab5b4b28bee916ff0f593e91 |
| institution | Directory Open Access Journal |
| issn | 1424-3997 |
| language | English |
| last_indexed | 2025-02-18T09:39:03Z |
| publishDate | 2013-08-01 |
| publisher | SMW supporting association (Trägerverein Swiss Medical Weekly SMW) |
| record_format | Article |
| series | Swiss Medical Weekly |
| spelling | doaj.art-7fd64be8ab5b4b28bee916ff0f593e912024-11-02T17:26:21ZengSMW supporting association (Trägerverein Swiss Medical Weekly SMW)Swiss Medical Weekly1424-39972013-08-01143353610.4414/smw.2013.13852QTc prolongation in methadone maintenance – the role of HCV infectionNajibulah GholamiLukas BoeschLuis FalcatoRudolf StohlerPhilip Bruggmann OBJECTIVES: Several studies have reported prolonged QTc intervals in patients under methadone maintenance treatment, including development of torsade-de-pointes arrhythmia and death. It is still not clear why some patients develop critical QTc extensions while others do not. METHODS: ECG findings in a convenience sample of 210 methadone-maintained heroin-dependent patients, taking HCV-infection status and methadone dosage into account simultaneously by means of a multiple linear regression model with QTc-interval as the dependent variable. RESULTS: Prolonged QTc-time is associated with hepatitis C infections (p = 0.005) and higher doses of racemic methadone (p = 0.012). CONCLUSION: Infection with hepatitis C increases the likelihood of critical QTc prolongation in patients in methadone maintenance treatment. https://www.smw.ch/index.php/smw/article/view/1743Hepatitis CMethadoneQT-prolongation |
| spellingShingle | Najibulah Gholami Lukas Boesch Luis Falcato Rudolf Stohler Philip Bruggmann QTc prolongation in methadone maintenance – the role of HCV infection Swiss Medical Weekly Hepatitis C Methadone QT-prolongation |
| title | QTc prolongation in methadone maintenance – the role of HCV infection |
| title_full | QTc prolongation in methadone maintenance – the role of HCV infection |
| title_fullStr | QTc prolongation in methadone maintenance – the role of HCV infection |
| title_full_unstemmed | QTc prolongation in methadone maintenance – the role of HCV infection |
| title_short | QTc prolongation in methadone maintenance – the role of HCV infection |
| title_sort | qtc prolongation in methadone maintenance the role of hcv infection |
| topic | Hepatitis C Methadone QT-prolongation |
| url | https://www.smw.ch/index.php/smw/article/view/1743 |
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