A New Hydroxylated Nonaprenylhydroquinone from the Mediterranean Marine Sponge Sarcotragus spinosulus

A New Hydroxylated Nonaprenylhydroquinone from the Mediterranean Marine Sponge Sarcotragus spinosulus

Chemical investigation of the Mediterranean sponge Sarcotragus spinosulus led to the isolation of a new hydroxylated nonaprenylhydroquinone, along with two known metabolites, hepta- and octaprenylhydroquinones. The structure of the new metabolite was assigned by extensive 1D and 2D NMR analyses and...

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Bibliographic Details
Main Authors: Mohamed Mehiri, Guillaume Robert, Vincent Guérineau, Jean Vacelet, Philippe Amade, Patrick Auberger, Maeva Dufies, Charline Abed, Nathalie Legrave
Format: Article
Language:English
Published: MDPI AG 2011-07-01
Series:Marine Drugs
Subjects:
ponges
Sarcotragus spinosulus
marine natural products
hydroxylated polyprenylhydroquinone
bioactivity
Online Access:http://www.mdpi.com/1660-3397/9/7/1210/
Description
Summary:Chemical investigation of the Mediterranean sponge Sarcotragus spinosulus led to the isolation of a new hydroxylated nonaprenylhydroquinone, along with two known metabolites, hepta- and octaprenylhydroquinones. The structure of the new metabolite was assigned by extensive 1D and 2D NMR analyses and MS studies. The antileukemic effect of the three compounds towards the chronic myelogenous leukemia (CML) cells line K562 was also evaluated.
ISSN:1660-3397

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