Susbstance P Levels in Children with Atopic Dermatitis
Background: Atopic dermatitis (AD) is the most common skin disease in infants and children. AD is influenced by hereditary and environmental factors, and it is characterized by an inflammatory reaction in the skin. In developing countries, children suffering from AD are estimated around 10–20%, of w...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Indonesian |
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Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga
2021-11-01
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| Series: | Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology) |
| Subjects: | |
| Online Access: | https://e-journal.unair.ac.id/BIKK/article/view/26625 |
| _version_ | 1827673589929738240 |
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| author | Khairina Nasution Deryne Anggia Paramita Nova Zairina Lubis |
| author_facet | Khairina Nasution Deryne Anggia Paramita Nova Zairina Lubis |
| author_sort | Khairina Nasution |
| collection | DOAJ |
| description | Background: Atopic dermatitis (AD) is the most common skin disease in infants and children. AD is influenced by hereditary and environmental factors, and it is characterized by an inflammatory reaction in the skin. In developing countries, children suffering from AD are estimated around 10–20%, of which 60% of the cases persist into adulthood. Substance P is a cutaneous neuropeptide that contributes to the pathogenesis of AD. Substance P promotes the production of nerve growth factors from keratinocytes, and the release of histamine, leukotriene, or tumor necrosis factor from mast cells, which cause the growth of sensory nerve fibers, augmentation of skin inflammation, and are considered pruritogenic factors. Purpose: This study aims to determine the description of substance P in children with atopic dermatitis using a descriptive observational study with a cross-sectional approach. Methods: This is a destructive observational study with a crossectional approach samples were selected from AD patients at the Universitas Sumatera Utara Hospital. Result: The largest group of subjects were childhood (2–12 years old), there was 60%, followed by the adolescent group (12–18 years old) and the infant group (<2 years old). In the childhood group, the highest level of substance P was found in girls with a mean of 349.03 ± 146.7. On the other hand, the highest levels of substance P in the adolescent were found in males with a mean of 243.73 ± 64.57 ng/L. Conclusion: In this study, we found that the level of substance p was higher in the childhood group. |
| first_indexed | 2024-03-10T04:26:53Z |
| format | Article |
| id | doaj.art-7fdaa752a1b74b1a9be5add1be3b2f0b |
| institution | Directory Open Access Journal |
| issn | 1978-4279 2549-4082 |
| language | Indonesian |
| last_indexed | 2024-03-10T04:26:53Z |
| publishDate | 2021-11-01 |
| publisher | Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga |
| record_format | Article |
| series | Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology) |
| spelling | doaj.art-7fdaa752a1b74b1a9be5add1be3b2f0b2023-11-23T06:34:48ZindDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas AirlanggaBerkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology)1978-42792549-40822021-11-0133318218610.20473/bikk.V33.3.2021.182-18621775Susbstance P Levels in Children with Atopic DermatitisKhairina Nasution0Deryne Anggia Paramita1Nova Zairina Lubis2Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, MedanDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, MedanDepartment of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, MedanBackground: Atopic dermatitis (AD) is the most common skin disease in infants and children. AD is influenced by hereditary and environmental factors, and it is characterized by an inflammatory reaction in the skin. In developing countries, children suffering from AD are estimated around 10–20%, of which 60% of the cases persist into adulthood. Substance P is a cutaneous neuropeptide that contributes to the pathogenesis of AD. Substance P promotes the production of nerve growth factors from keratinocytes, and the release of histamine, leukotriene, or tumor necrosis factor from mast cells, which cause the growth of sensory nerve fibers, augmentation of skin inflammation, and are considered pruritogenic factors. Purpose: This study aims to determine the description of substance P in children with atopic dermatitis using a descriptive observational study with a cross-sectional approach. Methods: This is a destructive observational study with a crossectional approach samples were selected from AD patients at the Universitas Sumatera Utara Hospital. Result: The largest group of subjects were childhood (2–12 years old), there was 60%, followed by the adolescent group (12–18 years old) and the infant group (<2 years old). In the childhood group, the highest level of substance P was found in girls with a mean of 349.03 ± 146.7. On the other hand, the highest levels of substance P in the adolescent were found in males with a mean of 243.73 ± 64.57 ng/L. Conclusion: In this study, we found that the level of substance p was higher in the childhood group.https://e-journal.unair.ac.id/BIKK/article/view/26625atopic dermatitissubstance pchildren |
| spellingShingle | Khairina Nasution Deryne Anggia Paramita Nova Zairina Lubis Susbstance P Levels in Children with Atopic Dermatitis Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology) atopic dermatitis substance p children |
| title | Susbstance P Levels in Children with Atopic Dermatitis |
| title_full | Susbstance P Levels in Children with Atopic Dermatitis |
| title_fullStr | Susbstance P Levels in Children with Atopic Dermatitis |
| title_full_unstemmed | Susbstance P Levels in Children with Atopic Dermatitis |
| title_short | Susbstance P Levels in Children with Atopic Dermatitis |
| title_sort | susbstance p levels in children with atopic dermatitis |
| topic | atopic dermatitis substance p children |
| url | https://e-journal.unair.ac.id/BIKK/article/view/26625 |
| work_keys_str_mv | AT khairinanasution susbstanceplevelsinchildrenwithatopicdermatitis AT deryneanggiaparamita susbstanceplevelsinchildrenwithatopicdermatitis AT novazairinalubis susbstanceplevelsinchildrenwithatopicdermatitis |