Expression of salivary immunoglobulins and their association with analgesic neuropeptide opiorphin in anorexia nervosa during adolescence
Plain English summary The orofacial region is affected by various inflammatory and autoimmune conditions, which might translate into general and regional changes. Saliva is one of the biological fluids where biomarkers of the aforementioned conditions, including sensitivity to pain, could be detecte...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | Journal of Eating Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40337-022-00637-3 |
| _version_ | 1797935897215238144 |
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| author | Elzbieta Paszynska Amadeusz Hernik Agnieszka Slopien Yves Boucher Marta Tyszkiewicz-Nwafor Magdalena Roszak Karolina Bilska Monika Dmitrzak-Weglarz |
| author_facet | Elzbieta Paszynska Amadeusz Hernik Agnieszka Slopien Yves Boucher Marta Tyszkiewicz-Nwafor Magdalena Roszak Karolina Bilska Monika Dmitrzak-Weglarz |
| author_sort | Elzbieta Paszynska |
| collection | DOAJ |
| description | Plain English summary The orofacial region is affected by various inflammatory and autoimmune conditions, which might translate into general and regional changes. Saliva is one of the biological fluids where biomarkers of the aforementioned conditions, including sensitivity to pain, could be detected. It is also noteworthy that anorexia nervosa (AN) and malnutrition may change the saliva's analgesic or immune content, but this scientific area is still not satisfactorily explored. The present work related to analgesic (opiorphin peptide) and anti-infectious agents (immunoglobulins Ig A, IgG, IgM) in said body fluid among 83 adolescent patients with severe AN compared to 79 healthy controls. In addition, oral hygiene levels were assessed in the oral cavity via the Plaque Control Record index (PCR). In the AN group, the concentration of opiorphin was significantly higher as compared to the control group, in contrast to IgM, which was significantly lower than in the control group. There were no notable differences in the levels of IgA and IgG between groups, despite a slightly higher concentrations of IgA in the AN group. A correlation was found between opiorphin and all immunoglobulins. A similar correlation was found between PCR index and all immunoglobulins.The present work shows how analgesic opiorphin depends on the oral inflammatory status. This might be a direction for further investigating the immune alterations in patients with AN-related malnutrition. Inclusion of AN patients in intensive oral hygiene care may also be considered. |
| first_indexed | 2024-04-10T18:21:20Z |
| format | Article |
| id | doaj.art-7fdce25f8c4b4235a3e78c830167697a |
| institution | Directory Open Access Journal |
| issn | 2050-2974 |
| language | English |
| last_indexed | 2024-04-10T18:21:20Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Eating Disorders |
| spelling | doaj.art-7fdce25f8c4b4235a3e78c830167697a2023-02-02T07:10:19ZengBMCJournal of Eating Disorders2050-29742022-08-0110111210.1186/s40337-022-00637-3Expression of salivary immunoglobulins and their association with analgesic neuropeptide opiorphin in anorexia nervosa during adolescenceElzbieta Paszynska0Amadeusz Hernik1Agnieszka Slopien2Yves Boucher3Marta Tyszkiewicz-Nwafor4Magdalena Roszak5Karolina Bilska6Monika Dmitrzak-Weglarz7Department of Integrated Dentistry, Poznan University of Medical Sciences (PUMS)Department of Integrated Dentistry, Poznan University of Medical Sciences (PUMS)Department of Child and Adolescent Psychiatry, PUMSUniversité de Paris, LabNOFDepartment of Child and Adolescent Psychiatry, PUMSDepartment of Computer Science and Statistics, PUMSDepartment of Psychiatric Genetics, Department of Psychiatry, PUMSDepartment of Psychiatric Genetics, Department of Psychiatry, PUMSPlain English summary The orofacial region is affected by various inflammatory and autoimmune conditions, which might translate into general and regional changes. Saliva is one of the biological fluids where biomarkers of the aforementioned conditions, including sensitivity to pain, could be detected. It is also noteworthy that anorexia nervosa (AN) and malnutrition may change the saliva's analgesic or immune content, but this scientific area is still not satisfactorily explored. The present work related to analgesic (opiorphin peptide) and anti-infectious agents (immunoglobulins Ig A, IgG, IgM) in said body fluid among 83 adolescent patients with severe AN compared to 79 healthy controls. In addition, oral hygiene levels were assessed in the oral cavity via the Plaque Control Record index (PCR). In the AN group, the concentration of opiorphin was significantly higher as compared to the control group, in contrast to IgM, which was significantly lower than in the control group. There were no notable differences in the levels of IgA and IgG between groups, despite a slightly higher concentrations of IgA in the AN group. A correlation was found between opiorphin and all immunoglobulins. A similar correlation was found between PCR index and all immunoglobulins.The present work shows how analgesic opiorphin depends on the oral inflammatory status. This might be a direction for further investigating the immune alterations in patients with AN-related malnutrition. Inclusion of AN patients in intensive oral hygiene care may also be considered.https://doi.org/10.1186/s40337-022-00637-3Anorexia nervosaSalivaImmunoglobulinsOpiorphinOral hygiene |
| spellingShingle | Elzbieta Paszynska Amadeusz Hernik Agnieszka Slopien Yves Boucher Marta Tyszkiewicz-Nwafor Magdalena Roszak Karolina Bilska Monika Dmitrzak-Weglarz Expression of salivary immunoglobulins and their association with analgesic neuropeptide opiorphin in anorexia nervosa during adolescence Journal of Eating Disorders Anorexia nervosa Saliva Immunoglobulins Opiorphin Oral hygiene |
| title | Expression of salivary immunoglobulins and their association with analgesic neuropeptide opiorphin in anorexia nervosa during adolescence |
| title_full | Expression of salivary immunoglobulins and their association with analgesic neuropeptide opiorphin in anorexia nervosa during adolescence |
| title_fullStr | Expression of salivary immunoglobulins and their association with analgesic neuropeptide opiorphin in anorexia nervosa during adolescence |
| title_full_unstemmed | Expression of salivary immunoglobulins and their association with analgesic neuropeptide opiorphin in anorexia nervosa during adolescence |
| title_short | Expression of salivary immunoglobulins and their association with analgesic neuropeptide opiorphin in anorexia nervosa during adolescence |
| title_sort | expression of salivary immunoglobulins and their association with analgesic neuropeptide opiorphin in anorexia nervosa during adolescence |
| topic | Anorexia nervosa Saliva Immunoglobulins Opiorphin Oral hygiene |
| url | https://doi.org/10.1186/s40337-022-00637-3 |
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