The long and winding road of reprogramming-induced rejuvenation
Abstract Organismal aging is inherently connected to the aging of its constituent cells and systems. Reducing the biological age of the organism may be assisted by reducing the age of its cells - an approach exemplified by partial cell reprogramming through the expression of Yamanaka factors or expo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-46020-5 |
| _version_ | 1797274036479197184 |
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| author | Ali Doğa Yücel Vadim N. Gladyshev |
| author_facet | Ali Doğa Yücel Vadim N. Gladyshev |
| author_sort | Ali Doğa Yücel |
| collection | DOAJ |
| description | Abstract Organismal aging is inherently connected to the aging of its constituent cells and systems. Reducing the biological age of the organism may be assisted by reducing the age of its cells - an approach exemplified by partial cell reprogramming through the expression of Yamanaka factors or exposure to chemical cocktails. It is crucial to protect cell type identity during partial reprogramming, as cells need to retain or rapidly regain their functions following the treatment. Another critical issue is the ability to quantify biological age as reprogrammed older cells acquire younger states. We discuss recent advances in reprogramming-induced rejuvenation and offer a critical review of this procedure and its relationship to the fundamental nature of aging. We further comparatively analyze partial reprogramming, full reprogramming and transdifferentiation approaches, assess safety concerns and emphasize the importance of distinguishing rejuvenation from dedifferentiation. Finally, we highlight translational opportunities that the reprogramming-induced rejuvenation approach offers. |
| first_indexed | 2024-03-07T14:52:39Z |
| format | Article |
| id | doaj.art-7fde43213b0f42579b5ea42981d77269 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-07T14:52:39Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7fde43213b0f42579b5ea42981d772692024-03-05T19:37:36ZengNature PortfolioNature Communications2041-17232024-03-011511910.1038/s41467-024-46020-5The long and winding road of reprogramming-induced rejuvenationAli Doğa Yücel0Vadim N. Gladyshev1Department of Molecular Biology and Genetics, Koc UniversityBrigham and Women’s Hospital, Harvard Medical SchoolAbstract Organismal aging is inherently connected to the aging of its constituent cells and systems. Reducing the biological age of the organism may be assisted by reducing the age of its cells - an approach exemplified by partial cell reprogramming through the expression of Yamanaka factors or exposure to chemical cocktails. It is crucial to protect cell type identity during partial reprogramming, as cells need to retain or rapidly regain their functions following the treatment. Another critical issue is the ability to quantify biological age as reprogrammed older cells acquire younger states. We discuss recent advances in reprogramming-induced rejuvenation and offer a critical review of this procedure and its relationship to the fundamental nature of aging. We further comparatively analyze partial reprogramming, full reprogramming and transdifferentiation approaches, assess safety concerns and emphasize the importance of distinguishing rejuvenation from dedifferentiation. Finally, we highlight translational opportunities that the reprogramming-induced rejuvenation approach offers.https://doi.org/10.1038/s41467-024-46020-5 |
| spellingShingle | Ali Doğa Yücel Vadim N. Gladyshev The long and winding road of reprogramming-induced rejuvenation Nature Communications |
| title | The long and winding road of reprogramming-induced rejuvenation |
| title_full | The long and winding road of reprogramming-induced rejuvenation |
| title_fullStr | The long and winding road of reprogramming-induced rejuvenation |
| title_full_unstemmed | The long and winding road of reprogramming-induced rejuvenation |
| title_short | The long and winding road of reprogramming-induced rejuvenation |
| title_sort | long and winding road of reprogramming induced rejuvenation |
| url | https://doi.org/10.1038/s41467-024-46020-5 |
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