Serum c-peptide level in newly diagnosed Bangladeshi adults with type 2 diabetes mellitus
C-peptide is produced in equimolar amounts to insulin and is the best measure of endogenous insulin secretion. This cross-sectional study was conducted in a tertiary hospital of Bangladesh from January 2016 to December 2017 to assess fasting serum c-peptide as a marker of the endogenous insulin secr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Sri Lanka College of Endocrinologists
2019-12-01
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| Series: | Sri Lanka Journal of Diabetes Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | https://sjdem.sljol.info/articles/7395 |
| _version_ | 1818596391348338688 |
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| author | A. K. M. Saber Ahmed A. B. M. Kamrul-Hasan Mohammed Ruhul-Kabir Habibur Rahman Mohammad Shofiullah A. F. M. Nazmul-Islam |
| author_facet | A. K. M. Saber Ahmed A. B. M. Kamrul-Hasan Mohammed Ruhul-Kabir Habibur Rahman Mohammad Shofiullah A. F. M. Nazmul-Islam |
| author_sort | A. K. M. Saber Ahmed |
| collection | DOAJ |
| description | C-peptide is produced in equimolar amounts to insulin and is the best measure of endogenous insulin secretion. This cross-sectional study was conducted in a tertiary hospital of Bangladesh from January 2016 to December 2017 to assess fasting serum c-peptide as a marker of the endogenous insulin secretory capacity in newly diagnosed subjects with type 2 diabetes mellitus (T2DM). 60 newly diagnosed T2DM subjects were investigated along with 30 age-sex matched healthy controls. Fasting c-peptide was significantly higher in T2DM subjects than controls (8.97±5.96 vs. 1.69±0.66 ng/ml). None of the T2DM subjects had subnormal c-peptide, 19 (32%) had normal c-peptide, and 41 (68%) of them had elevated c-peptide levels. Higher fasting plasma glucose (FPG), plasma glucose 2-hours after 75gm oral glucose tolerance test (PG 2H-OGTT) and HbA1c levels were observed in T2DM subjects with elevated c-peptide in comparison to T2DM subjects having normal c-peptide. In T2DM subjects, c-peptide showed significant positive correlations with body mass index (BMI), FPG, PG 2H-OGTT, and HbA1c. This study found higher levels of fasting c-peptide in newly diagnosed T2DM in comparison to nondiabetic controls. None of the T2DM subjects had a subnormal c-peptide level. |
| first_indexed | 2024-12-16T11:31:10Z |
| format | Article |
| id | doaj.art-7fdecc243e6343b895be2ad9c1bfece1 |
| institution | Directory Open Access Journal |
| issn | 2012-998X |
| language | English |
| last_indexed | 2024-12-16T11:31:10Z |
| publishDate | 2019-12-01 |
| publisher | Sri Lanka College of Endocrinologists |
| record_format | Article |
| series | Sri Lanka Journal of Diabetes Endocrinology and Metabolism |
| spelling | doaj.art-7fdecc243e6343b895be2ad9c1bfece12022-12-21T22:33:14ZengSri Lanka College of EndocrinologistsSri Lanka Journal of Diabetes Endocrinology and Metabolism2012-998X2019-12-0192253010.4038/sjdem.v9i2.73955619Serum c-peptide level in newly diagnosed Bangladeshi adults with type 2 diabetes mellitusA. K. M. Saber Ahmed0A. B. M. Kamrul-Hasan1Mohammed Ruhul-Kabir2Habibur Rahman3Mohammad Shofiullah4A. F. M. Nazmul-Islam5Sylhet M A G Osmani Medical College, SylhetMymensingh Medical College Hospital, MymensinghSylhet M A G Osmani Medical College, SylhetSylhet M A G Osmani Medical College, SylhetSylhet M A G Osmani Medical College, SylhetSylhet M A G Osmani Medical College, SylhetC-peptide is produced in equimolar amounts to insulin and is the best measure of endogenous insulin secretion. This cross-sectional study was conducted in a tertiary hospital of Bangladesh from January 2016 to December 2017 to assess fasting serum c-peptide as a marker of the endogenous insulin secretory capacity in newly diagnosed subjects with type 2 diabetes mellitus (T2DM). 60 newly diagnosed T2DM subjects were investigated along with 30 age-sex matched healthy controls. Fasting c-peptide was significantly higher in T2DM subjects than controls (8.97±5.96 vs. 1.69±0.66 ng/ml). None of the T2DM subjects had subnormal c-peptide, 19 (32%) had normal c-peptide, and 41 (68%) of them had elevated c-peptide levels. Higher fasting plasma glucose (FPG), plasma glucose 2-hours after 75gm oral glucose tolerance test (PG 2H-OGTT) and HbA1c levels were observed in T2DM subjects with elevated c-peptide in comparison to T2DM subjects having normal c-peptide. In T2DM subjects, c-peptide showed significant positive correlations with body mass index (BMI), FPG, PG 2H-OGTT, and HbA1c. This study found higher levels of fasting c-peptide in newly diagnosed T2DM in comparison to nondiabetic controls. None of the T2DM subjects had a subnormal c-peptide level.https://sjdem.sljol.info/articles/7395type 2 diabetes, endogenous insulin, c-peptide, insulin secretion |
| spellingShingle | A. K. M. Saber Ahmed A. B. M. Kamrul-Hasan Mohammed Ruhul-Kabir Habibur Rahman Mohammad Shofiullah A. F. M. Nazmul-Islam Serum c-peptide level in newly diagnosed Bangladeshi adults with type 2 diabetes mellitus Sri Lanka Journal of Diabetes Endocrinology and Metabolism type 2 diabetes, endogenous insulin, c-peptide, insulin secretion |
| title | Serum c-peptide level in newly diagnosed Bangladeshi adults with type 2 diabetes mellitus |
| title_full | Serum c-peptide level in newly diagnosed Bangladeshi adults with type 2 diabetes mellitus |
| title_fullStr | Serum c-peptide level in newly diagnosed Bangladeshi adults with type 2 diabetes mellitus |
| title_full_unstemmed | Serum c-peptide level in newly diagnosed Bangladeshi adults with type 2 diabetes mellitus |
| title_short | Serum c-peptide level in newly diagnosed Bangladeshi adults with type 2 diabetes mellitus |
| title_sort | serum c peptide level in newly diagnosed bangladeshi adults with type 2 diabetes mellitus |
| topic | type 2 diabetes, endogenous insulin, c-peptide, insulin secretion |
| url | https://sjdem.sljol.info/articles/7395 |
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