Comparison of choroidal thickness measurements using swept source and spectral domain optical coherence tomography in pachychoroid diseases.
PURPOSE:To determine the comparability of choroidal thickness (ChT) measurements using swept source (SS) and spectral domain (SD) optical coherence tomography (OCT) devices in patients with pachychoroid diseases. METHODS:Patients with pachychoroid diseases were recruited. OCT scans were performed se...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0229134 |
| _version_ | 1818933672332492800 |
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| author | Min-Woo Lee Hye-Jin Park Yong-Il Shin Woo-Hyuk Lee Hyung-Bin Lim Jung-Yeul Kim |
| author_facet | Min-Woo Lee Hye-Jin Park Yong-Il Shin Woo-Hyuk Lee Hyung-Bin Lim Jung-Yeul Kim |
| author_sort | Min-Woo Lee |
| collection | DOAJ |
| description | PURPOSE:To determine the comparability of choroidal thickness (ChT) measurements using swept source (SS) and spectral domain (SD) optical coherence tomography (OCT) devices in patients with pachychoroid diseases. METHODS:Patients with pachychoroid diseases were recruited. OCT scans were performed sequentially with a Cirrus HD OCT 5000 and Plex Elite 9000. Images were analyzed by two independent observers. Each image was independently measured twice by each observer to determine the intraobserver repeatability. RESULTS:A total of 55 eyes were included. The average ChT of the subfoveal area using SS-OCT and SD-OCT was 430.5 ± 68.1 and 428.5 ± 57.9 μm, respectively, which did not show a significant result as the main effect in the repeated-measure analysis of variance (P = 0.067). Using SS-OCT, the intraobserver intraclass correlation coefficient (ICC) of both observers was > 0.950 at every measured point, and the interobserver coefficient of repeatability (CR) of the subfoveal area was 45.1 μm (95% confidence interval (CI), 40.8-49.4). Using SD-OCT, the intraobserver ICC of both observers was > 0.800, and the interobserver CR of the subfoveal area was 71.2 μm (95% CI, 64.4-78.0). Additionally, the intraobserver and interobserver CRs showed significantly better repeatability in SS-OCT than SD-OCT in F-test. In patients with ChT ≥ 400 μm, the interobserver CRs of SS-OCT and SD-OCT were 48.4 (95% CI, 42.6-54.2) and 95.2 μm (95% CI, 83.9-106.6), respectively. In patients with a subfoveal active lesion, the interobserver CRs were 44.5 (95% CI, 37.6-51.4) and 100.1 μm (95% CI, 84.6-115.5), respectively. CONCLUSIONS:Although the ChT measurements were comparable between SS-OCT and SD-OCT devices in pachychoroid diseases, SD-OCT showed low reliability in patients with ChT ≥ 400 μm and subfoveal active lesions. SS-OCT would be therefore more suitable for observation and follow-up of choroidal structures in pachychoroid diseases. |
| first_indexed | 2024-12-20T04:52:06Z |
| format | Article |
| id | doaj.art-7fdf30a810a948f5859929253c91df29 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T04:52:06Z |
| publishDate | 2020-01-01 |
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| spelling | doaj.art-7fdf30a810a948f5859929253c91df292022-12-21T19:52:50ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01152e022913410.1371/journal.pone.0229134Comparison of choroidal thickness measurements using swept source and spectral domain optical coherence tomography in pachychoroid diseases.Min-Woo LeeHye-Jin ParkYong-Il ShinWoo-Hyuk LeeHyung-Bin LimJung-Yeul KimPURPOSE:To determine the comparability of choroidal thickness (ChT) measurements using swept source (SS) and spectral domain (SD) optical coherence tomography (OCT) devices in patients with pachychoroid diseases. METHODS:Patients with pachychoroid diseases were recruited. OCT scans were performed sequentially with a Cirrus HD OCT 5000 and Plex Elite 9000. Images were analyzed by two independent observers. Each image was independently measured twice by each observer to determine the intraobserver repeatability. RESULTS:A total of 55 eyes were included. The average ChT of the subfoveal area using SS-OCT and SD-OCT was 430.5 ± 68.1 and 428.5 ± 57.9 μm, respectively, which did not show a significant result as the main effect in the repeated-measure analysis of variance (P = 0.067). Using SS-OCT, the intraobserver intraclass correlation coefficient (ICC) of both observers was > 0.950 at every measured point, and the interobserver coefficient of repeatability (CR) of the subfoveal area was 45.1 μm (95% confidence interval (CI), 40.8-49.4). Using SD-OCT, the intraobserver ICC of both observers was > 0.800, and the interobserver CR of the subfoveal area was 71.2 μm (95% CI, 64.4-78.0). Additionally, the intraobserver and interobserver CRs showed significantly better repeatability in SS-OCT than SD-OCT in F-test. In patients with ChT ≥ 400 μm, the interobserver CRs of SS-OCT and SD-OCT were 48.4 (95% CI, 42.6-54.2) and 95.2 μm (95% CI, 83.9-106.6), respectively. In patients with a subfoveal active lesion, the interobserver CRs were 44.5 (95% CI, 37.6-51.4) and 100.1 μm (95% CI, 84.6-115.5), respectively. CONCLUSIONS:Although the ChT measurements were comparable between SS-OCT and SD-OCT devices in pachychoroid diseases, SD-OCT showed low reliability in patients with ChT ≥ 400 μm and subfoveal active lesions. SS-OCT would be therefore more suitable for observation and follow-up of choroidal structures in pachychoroid diseases.https://doi.org/10.1371/journal.pone.0229134 |
| spellingShingle | Min-Woo Lee Hye-Jin Park Yong-Il Shin Woo-Hyuk Lee Hyung-Bin Lim Jung-Yeul Kim Comparison of choroidal thickness measurements using swept source and spectral domain optical coherence tomography in pachychoroid diseases. PLoS ONE |
| title | Comparison of choroidal thickness measurements using swept source and spectral domain optical coherence tomography in pachychoroid diseases. |
| title_full | Comparison of choroidal thickness measurements using swept source and spectral domain optical coherence tomography in pachychoroid diseases. |
| title_fullStr | Comparison of choroidal thickness measurements using swept source and spectral domain optical coherence tomography in pachychoroid diseases. |
| title_full_unstemmed | Comparison of choroidal thickness measurements using swept source and spectral domain optical coherence tomography in pachychoroid diseases. |
| title_short | Comparison of choroidal thickness measurements using swept source and spectral domain optical coherence tomography in pachychoroid diseases. |
| title_sort | comparison of choroidal thickness measurements using swept source and spectral domain optical coherence tomography in pachychoroid diseases |
| url | https://doi.org/10.1371/journal.pone.0229134 |
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