Biological Properties, Health Benefits and Enzymatic Modifications of Dietary Methoxylated Derivatives of Cinnamic Acid

Methoxylated derivatives of cinnamic acid play an important role in the formation of the pro-health potential of food products. Numerous reports present them as molecules with strong antimicrobial, antidiabetic, anticancer as well as hepato-, cardio-, and neuroprotective activities. In the last thre...

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Main Authors: Magdalena Rychlicka, Agata Rot, Anna Gliszczyńska
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Foods
Subjects:
Online Access:https://www.mdpi.com/2304-8158/10/6/1417
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author Magdalena Rychlicka
Agata Rot
Anna Gliszczyńska
author_facet Magdalena Rychlicka
Agata Rot
Anna Gliszczyńska
author_sort Magdalena Rychlicka
collection DOAJ
description Methoxylated derivatives of cinnamic acid play an important role in the formation of the pro-health potential of food products. Numerous reports present them as molecules with strong antimicrobial, antidiabetic, anticancer as well as hepato-, cardio-, and neuroprotective activities. In the last three decades, many research groups have tried to extend the practical application of these molecules as therapeutic and antioxidant agents extensively studying the methods of their lipophilization as the solution of problems of their low oral bioavailability and rapid metabolism. This article summarizes the latest data of natural sources of occurrence, biological potential and bioavailability of methoxy derivatives of cinnamic acids. Metabolism and pharmacokinetics of this group of dietary compounds are also extensively discussed as well as reviewing the methods of their chemical and enzymatic lipophilization in the aspect of their use in food and pharmaceutical industries.
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spelling doaj.art-7fdfdce281f5498ab7edc3e9daf671c72023-11-22T00:45:38ZengMDPI AGFoods2304-81582021-06-01106141710.3390/foods10061417Biological Properties, Health Benefits and Enzymatic Modifications of Dietary Methoxylated Derivatives of Cinnamic AcidMagdalena Rychlicka0Agata Rot1Anna Gliszczyńska2Department of Chemistry, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, PolandDepartment of Chemistry, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, PolandDepartment of Chemistry, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, PolandMethoxylated derivatives of cinnamic acid play an important role in the formation of the pro-health potential of food products. Numerous reports present them as molecules with strong antimicrobial, antidiabetic, anticancer as well as hepato-, cardio-, and neuroprotective activities. In the last three decades, many research groups have tried to extend the practical application of these molecules as therapeutic and antioxidant agents extensively studying the methods of their lipophilization as the solution of problems of their low oral bioavailability and rapid metabolism. This article summarizes the latest data of natural sources of occurrence, biological potential and bioavailability of methoxy derivatives of cinnamic acids. Metabolism and pharmacokinetics of this group of dietary compounds are also extensively discussed as well as reviewing the methods of their chemical and enzymatic lipophilization in the aspect of their use in food and pharmaceutical industries.https://www.mdpi.com/2304-8158/10/6/1417methoxylated derivatives of cinnamic acidbiological activitybioavailabilitylipidsphospholipids
spellingShingle Magdalena Rychlicka
Agata Rot
Anna Gliszczyńska
Biological Properties, Health Benefits and Enzymatic Modifications of Dietary Methoxylated Derivatives of Cinnamic Acid
Foods
methoxylated derivatives of cinnamic acid
biological activity
bioavailability
lipids
phospholipids
title Biological Properties, Health Benefits and Enzymatic Modifications of Dietary Methoxylated Derivatives of Cinnamic Acid
title_full Biological Properties, Health Benefits and Enzymatic Modifications of Dietary Methoxylated Derivatives of Cinnamic Acid
title_fullStr Biological Properties, Health Benefits and Enzymatic Modifications of Dietary Methoxylated Derivatives of Cinnamic Acid
title_full_unstemmed Biological Properties, Health Benefits and Enzymatic Modifications of Dietary Methoxylated Derivatives of Cinnamic Acid
title_short Biological Properties, Health Benefits and Enzymatic Modifications of Dietary Methoxylated Derivatives of Cinnamic Acid
title_sort biological properties health benefits and enzymatic modifications of dietary methoxylated derivatives of cinnamic acid
topic methoxylated derivatives of cinnamic acid
biological activity
bioavailability
lipids
phospholipids
url https://www.mdpi.com/2304-8158/10/6/1417
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AT agatarot biologicalpropertieshealthbenefitsandenzymaticmodificationsofdietarymethoxylatedderivativesofcinnamicacid
AT annagliszczynska biologicalpropertieshealthbenefitsandenzymaticmodificationsofdietarymethoxylatedderivativesofcinnamicacid