Phonemic fluency in post-ICU patients after severe COVID-19 infection: The role of cognitive reserve
Introduction Cognitive function may be impaired in COVID-19 patients, especially in executive functions such as phonemic fluency. Among risk factors, inflammation during hospitalization is related with worse cognitive performance in the long term. On the other side, it has been shown that cognitive...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822009543/type/journal_article |
| _version_ | 1797616651444682752 |
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| author | X. Segú M. Primé Tous M. Sanchez F. Valdesoiro A. Rodriguez I. Martín A. Costas |
| author_facet | X. Segú M. Primé Tous M. Sanchez F. Valdesoiro A. Rodriguez I. Martín A. Costas |
| author_sort | X. Segú |
| collection | DOAJ |
| description |
Introduction
Cognitive function may be impaired in COVID-19 patients, especially in executive functions such as phonemic fluency. Among risk factors, inflammation during hospitalization is related with worse cognitive performance in the long term. On the other side, it has been shown that cognitive reserve (CR) protects against cognitive impairment associated with brain damage, psychiatric disorders and neurodegenerative diseases.
Objectives
Our aim is to study the protective role of cognitive reserve in phonemic fluency to inflammation after SARS-CoV-2 infection.
Methods
We enrolled a cohort of 102 severe SARS-CoV-2 survivors after Intensive Care Unit (ICU) discharge and 58 agreed to participate in this 6-month follow-up study. Patients with previously known cognitive impairment were excluded. Demographic, clinical and laboratory data were collected. To assess the phonemic fluency, we used the Controlled Oral Word Association Test (COWAT) controlling the effects of age and education. Inflammation was recorded according to the number of days with high CRP. ANCOVA analyses were used to test the effect of interaction between medical variables and cognitive reserve on phonemic fluency.
Results
The COVID-19 inflammation interacted with CR in phonemic fluency (F= 6.47, p= 0.01), with worse performance in patients with low CR (mean 16.7 (10.2-23.3)) than those with high CR (mean 37.7 (34.3-41.2)) in function of number of days with high PCR during ICU stay.
Conclusions
The role of the cognitive reserve is important to reduce the cognitive impairment related with COVID-19 inflammation in post-ICU patients.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:44:16Z |
| format | Article |
| id | doaj.art-7fe01b2181ac4807a1135b0b807ea4e9 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:44:16Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-7fe01b2181ac4807a1135b0b807ea4e92023-11-17T05:07:56ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S376S37610.1192/j.eurpsy.2022.954Phonemic fluency in post-ICU patients after severe COVID-19 infection: The role of cognitive reserveX. Segú0M. Primé Tous1M. Sanchez2F. Valdesoiro3A. Rodriguez4I. Martín5A. Costas6Hospital Clínic de Barcelona, Department Of Psychiatry And Psychology, Barcelona, SpainHospital Clínic de Barcelona, Department Of Psychiatry And Psychology, Barcelona, SpainHospital Clínic de Barcelona, Department Of Psychiatry And Psychology, Barcelona, SpainHospital Clínic de Barcelona, Department Of Psychiatry And Psychology, Barcelona, SpainHospital Clínic de Barcelona, Department Of Psychiatry And Psychology, Barcelona, SpainHospital Clínic de Barcelona, Department Of Psychiatry And Psychology, Barcelona, SpainHospital Clínic de Barcelona, Department Of Psychiatry And Psychology, Barcelona, Spain Introduction Cognitive function may be impaired in COVID-19 patients, especially in executive functions such as phonemic fluency. Among risk factors, inflammation during hospitalization is related with worse cognitive performance in the long term. On the other side, it has been shown that cognitive reserve (CR) protects against cognitive impairment associated with brain damage, psychiatric disorders and neurodegenerative diseases. Objectives Our aim is to study the protective role of cognitive reserve in phonemic fluency to inflammation after SARS-CoV-2 infection. Methods We enrolled a cohort of 102 severe SARS-CoV-2 survivors after Intensive Care Unit (ICU) discharge and 58 agreed to participate in this 6-month follow-up study. Patients with previously known cognitive impairment were excluded. Demographic, clinical and laboratory data were collected. To assess the phonemic fluency, we used the Controlled Oral Word Association Test (COWAT) controlling the effects of age and education. Inflammation was recorded according to the number of days with high CRP. ANCOVA analyses were used to test the effect of interaction between medical variables and cognitive reserve on phonemic fluency. Results The COVID-19 inflammation interacted with CR in phonemic fluency (F= 6.47, p= 0.01), with worse performance in patients with low CR (mean 16.7 (10.2-23.3)) than those with high CR (mean 37.7 (34.3-41.2)) in function of number of days with high PCR during ICU stay. Conclusions The role of the cognitive reserve is important to reduce the cognitive impairment related with COVID-19 inflammation in post-ICU patients. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822009543/type/journal_articlecognitive impairmentNeurological manifestationsCovid-19Cognitive reserve |
| spellingShingle | X. Segú M. Primé Tous M. Sanchez F. Valdesoiro A. Rodriguez I. Martín A. Costas Phonemic fluency in post-ICU patients after severe COVID-19 infection: The role of cognitive reserve European Psychiatry cognitive impairment Neurological manifestations Covid-19 Cognitive reserve |
| title | Phonemic fluency in post-ICU patients after severe COVID-19 infection: The role of cognitive reserve |
| title_full | Phonemic fluency in post-ICU patients after severe COVID-19 infection: The role of cognitive reserve |
| title_fullStr | Phonemic fluency in post-ICU patients after severe COVID-19 infection: The role of cognitive reserve |
| title_full_unstemmed | Phonemic fluency in post-ICU patients after severe COVID-19 infection: The role of cognitive reserve |
| title_short | Phonemic fluency in post-ICU patients after severe COVID-19 infection: The role of cognitive reserve |
| title_sort | phonemic fluency in post icu patients after severe covid 19 infection the role of cognitive reserve |
| topic | cognitive impairment Neurological manifestations Covid-19 Cognitive reserve |
| url | https://www.cambridge.org/core/product/identifier/S0924933822009543/type/journal_article |
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