Parishin From Gastrodia Elata Ameliorates Aging Phenotype in Mice in a Gut Microbiota-Related Manner
The physiological and pathological processes that accompany aging can seriously affect the quality of life of the elderly population. Therefore, delaying aging and developing antiaging products have become popular areas of inquiry. Gut microbiota plays an important role in age-related phenotypes. Th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.877099/full |
| _version_ | 1818048560960110592 |
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| author | Xinxiu Zhao Shixian Zhou Ren Yan Caixia Gong Qifeng Gui Qin Zhang Lan Xiang Lufang Chen Peixia Wang Shumin Li Yunmei Yang |
| author_facet | Xinxiu Zhao Shixian Zhou Ren Yan Caixia Gong Qifeng Gui Qin Zhang Lan Xiang Lufang Chen Peixia Wang Shumin Li Yunmei Yang |
| author_sort | Xinxiu Zhao |
| collection | DOAJ |
| description | The physiological and pathological processes that accompany aging can seriously affect the quality of life of the elderly population. Therefore, delaying aging and developing antiaging products have become popular areas of inquiry. Gut microbiota plays an important role in age-related phenotypes. The present study aimed to investigate the antiaging effects and underlying mechanism of parishin, a phenolic glucoside isolated from traditional Chinese medicine Gastrodia elata. Samples from adult (12 weeks), low-dose (10 mg/kg/d) or high-dose (20 mg/kg/d) parishin-treated and untreated aged (19 months) mice were collected to determine blood indicators, gut microbiota and metabolome, and cardiopulmonary histopathological features. The results showed that parishin treatment ameliorates aging-induced cardiopulmonary fibrosis and increase in serum p16Ink4a, GDF15, and IL-6 levels. Furthermore, parishin treatment alleviated dysbiosis in gut microbiota, including altered microbial diversity and the aberrant abundance of opportunistic pathogenic bacteria such as Turicibacter and Erysipelatoclostridium. Gene function prediction and gut metabolome analysis results indicated that the parishin treatment-altered gut microbiota played important roles in sugar, lipid, amino acid and nucleic acid metabolism, and improved gut metabolic disorders in aged mice. In conclusion, the present study provides an experimental basis of potential applications of parishin against aging. |
| first_indexed | 2024-12-10T10:23:38Z |
| format | Article |
| id | doaj.art-7fe208f2f77e40e2a3849c4ef7ba7247 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-10T10:23:38Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-7fe208f2f77e40e2a3849c4ef7ba72472022-12-22T01:52:48ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-04-011310.3389/fmicb.2022.877099877099Parishin From Gastrodia Elata Ameliorates Aging Phenotype in Mice in a Gut Microbiota-Related MannerXinxiu Zhao0Shixian Zhou1Ren Yan2Caixia Gong3Qifeng Gui4Qin Zhang5Lan Xiang6Lufang Chen7Peixia Wang8Shumin Li9Yunmei Yang10Department of Geriatrics, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Geriatrics, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaState Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory of Diagnosis and Treatment of Aging and Physic-Chemical Injury Diseases of Zhejiang Province, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Geriatrics, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Geriatrics, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou, ChinaDepartment of Geriatrics, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Geriatrics, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Geriatrics, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Geriatrics, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaThe physiological and pathological processes that accompany aging can seriously affect the quality of life of the elderly population. Therefore, delaying aging and developing antiaging products have become popular areas of inquiry. Gut microbiota plays an important role in age-related phenotypes. The present study aimed to investigate the antiaging effects and underlying mechanism of parishin, a phenolic glucoside isolated from traditional Chinese medicine Gastrodia elata. Samples from adult (12 weeks), low-dose (10 mg/kg/d) or high-dose (20 mg/kg/d) parishin-treated and untreated aged (19 months) mice were collected to determine blood indicators, gut microbiota and metabolome, and cardiopulmonary histopathological features. The results showed that parishin treatment ameliorates aging-induced cardiopulmonary fibrosis and increase in serum p16Ink4a, GDF15, and IL-6 levels. Furthermore, parishin treatment alleviated dysbiosis in gut microbiota, including altered microbial diversity and the aberrant abundance of opportunistic pathogenic bacteria such as Turicibacter and Erysipelatoclostridium. Gene function prediction and gut metabolome analysis results indicated that the parishin treatment-altered gut microbiota played important roles in sugar, lipid, amino acid and nucleic acid metabolism, and improved gut metabolic disorders in aged mice. In conclusion, the present study provides an experimental basis of potential applications of parishin against aging.https://www.frontiersin.org/articles/10.3389/fmicb.2022.877099/fulltraditional Chinese medicinenatural productsantiaginggut microbiotametabolome |
| spellingShingle | Xinxiu Zhao Shixian Zhou Ren Yan Caixia Gong Qifeng Gui Qin Zhang Lan Xiang Lufang Chen Peixia Wang Shumin Li Yunmei Yang Parishin From Gastrodia Elata Ameliorates Aging Phenotype in Mice in a Gut Microbiota-Related Manner Frontiers in Microbiology traditional Chinese medicine natural products antiaging gut microbiota metabolome |
| title | Parishin From Gastrodia Elata Ameliorates Aging Phenotype in Mice in a Gut Microbiota-Related Manner |
| title_full | Parishin From Gastrodia Elata Ameliorates Aging Phenotype in Mice in a Gut Microbiota-Related Manner |
| title_fullStr | Parishin From Gastrodia Elata Ameliorates Aging Phenotype in Mice in a Gut Microbiota-Related Manner |
| title_full_unstemmed | Parishin From Gastrodia Elata Ameliorates Aging Phenotype in Mice in a Gut Microbiota-Related Manner |
| title_short | Parishin From Gastrodia Elata Ameliorates Aging Phenotype in Mice in a Gut Microbiota-Related Manner |
| title_sort | parishin from gastrodia elata ameliorates aging phenotype in mice in a gut microbiota related manner |
| topic | traditional Chinese medicine natural products antiaging gut microbiota metabolome |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.877099/full |
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