Signal-averaged electrocardiography as a noninvasive tool for evaluating the ventricular substrate in patients with nonischemic cardiomyopathy: reassessment of an old tool
IntroductionSignal-averaged electrocardiography (SAECG) provides diagnostic and prognostic information regarding cardiac diseases. However, its value in other nonischemic cardiomyopathies (NICMs) remains unclear. This study aimed to investigate the role of SAECG in patients with NICM.Methods and res...
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1306055/full |
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| author | Dinh Son Ngoc Nguyen Dinh Son Ngoc Nguyen Chin-Yu Lin Chin-Yu Lin Fa-Po Chung Fa-Po Chung Ting-Yung Chang Ting-Yung Chang Li-Wei Lo Li-Wei Lo Yenn-Jiang Lin Yenn-Jiang Lin Shih-Lin Chang Shih-Lin Chang Yu-Feng Hu Yu-Feng Hu Ta-Chuan Tuan Ta-Chuan Tuan Tze-Fan Chao Tze-Fan Chao Jo-Nan Liao Jo-Nan Liao Ling Kuo Ling Kuo Chih-Min Liu Chih-Min Liu Shin-Huei Liu Shin-Huei Liu Cheng-I Wu Cheng-I Wu Ming-Jen Kuo Guan-Yi Li Yu-Shan Huang Shang-Ju Wu Shang-Ju Wu Yoon Kee Siow Yoon Kee Siow Jose Antonio L. Bautista Jose Antonio L. Bautista Dat Tran Cao Dat Tran Cao Shih-Ann Chen Shih-Ann Chen Shih-Ann Chen Shih-Ann Chen |
| author_facet | Dinh Son Ngoc Nguyen Dinh Son Ngoc Nguyen Chin-Yu Lin Chin-Yu Lin Fa-Po Chung Fa-Po Chung Ting-Yung Chang Ting-Yung Chang Li-Wei Lo Li-Wei Lo Yenn-Jiang Lin Yenn-Jiang Lin Shih-Lin Chang Shih-Lin Chang Yu-Feng Hu Yu-Feng Hu Ta-Chuan Tuan Ta-Chuan Tuan Tze-Fan Chao Tze-Fan Chao Jo-Nan Liao Jo-Nan Liao Ling Kuo Ling Kuo Chih-Min Liu Chih-Min Liu Shin-Huei Liu Shin-Huei Liu Cheng-I Wu Cheng-I Wu Ming-Jen Kuo Guan-Yi Li Yu-Shan Huang Shang-Ju Wu Shang-Ju Wu Yoon Kee Siow Yoon Kee Siow Jose Antonio L. Bautista Jose Antonio L. Bautista Dat Tran Cao Dat Tran Cao Shih-Ann Chen Shih-Ann Chen Shih-Ann Chen Shih-Ann Chen |
| author_sort | Dinh Son Ngoc Nguyen |
| collection | DOAJ |
| description | IntroductionSignal-averaged electrocardiography (SAECG) provides diagnostic and prognostic information regarding cardiac diseases. However, its value in other nonischemic cardiomyopathies (NICMs) remains unclear. This study aimed to investigate the role of SAECG in patients with NICM.Methods and resultsThis retrospective study included consecutive patients with NICM who underwent SAECG, biventricular substrate mapping, and ablation for ventricular arrhythmia (VA). Patients with baseline ventricular conduction disturbances were excluded. Patients who fulfilled at least one SAECG criterion were categorized into Group 1, and the other patients were categorized into Group 2. Baseline and ventricular substrate characteristics were compared between the two groups. The study included 58 patients (39 men, mean age 50.4 ± 15.5 years), with 34 and 24 patients in Groups 1 and 2, respectively. Epicardial mapping was performed in eight (23.5%) and six patients (25.0%) in Groups 1 and 2 (p = 0.897), respectively. Patients in Group 1 had a more extensive right ventricular (RV) low-voltage zone (LVZ) and scar area than those in Group 2. Group 1 had a larger epicardial LVZ than Group 2. Epicardial late potentials were more frequent in Group 1 than in Group 2. There were more arrhythmogenic foci within the RV outflow tract in Group 1 than in Group 2. There was no significant difference in long-term VA recurrence.ConclusionIn our NICM population, a positive SAECG was associated with a larger RV endocardial scar, epicardial scar/late potentials, and a higher incidence of arrhythmogenic foci in the RV outflow tract. |
| first_indexed | 2024-04-24T08:57:38Z |
| format | Article |
| id | doaj.art-7fe2af820d5b462490b5f1d9e76f70e1 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-24T08:57:38Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-7fe2af820d5b462490b5f1d9e76f70e12024-04-16T05:02:16ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-04-011110.3389/fcvm.2024.13060551306055Signal-averaged electrocardiography as a noninvasive tool for evaluating the ventricular substrate in patients with nonischemic cardiomyopathy: reassessment of an old toolDinh Son Ngoc Nguyen0Dinh Son Ngoc Nguyen1Chin-Yu Lin2Chin-Yu Lin3Fa-Po Chung4Fa-Po Chung5Ting-Yung Chang6Ting-Yung Chang7Li-Wei Lo8Li-Wei Lo9Yenn-Jiang Lin10Yenn-Jiang Lin11Shih-Lin Chang12Shih-Lin Chang13Yu-Feng Hu14Yu-Feng Hu15Ta-Chuan Tuan16Ta-Chuan Tuan17Tze-Fan Chao18Tze-Fan Chao19Jo-Nan Liao20Jo-Nan Liao21Ling Kuo22Ling Kuo23Chih-Min Liu24Chih-Min Liu25Shin-Huei Liu26Shin-Huei Liu27Cheng-I Wu28Cheng-I Wu29Ming-Jen Kuo30Guan-Yi Li31Yu-Shan Huang32Shang-Ju Wu33Shang-Ju Wu34Yoon Kee Siow35Yoon Kee Siow36Jose Antonio L. Bautista37Jose Antonio L. Bautista38Dat Tran Cao39Dat Tran Cao40Shih-Ann Chen41Shih-Ann Chen42Shih-Ann Chen43Shih-Ann Chen44Division of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei City, TaiwanCardiology Department, University Medical Center, Ho Chi Minh City, VietnamDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei City, TaiwanInstitute of Clinical Medicine, National Yang-Ming University, Taipei, TaiwanDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei City, TaiwanInstitute of Clinical Medicine, National Yang-Ming University, Taipei, TaiwanDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei City, TaiwanInstitute of Clinical Medicine, National Yang-Ming University, Taipei, TaiwanDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei City, TaiwanInstitute of Clinical Medicine, National Yang-Ming University, Taipei, TaiwanDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei City, TaiwanInstitute of Clinical Medicine, National Yang-Ming University, Taipei, TaiwanDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei City, TaiwanInstitute of Clinical Medicine, National Yang-Ming University, Taipei, TaiwanDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei City, TaiwanInstitute of Clinical Medicine, National Yang-Ming University, Taipei, TaiwanDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei City, TaiwanInstitute of Clinical Medicine, National Yang-Ming University, Taipei, TaiwanDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei City, TaiwanInstitute of Clinical Medicine, National Yang-Ming University, Taipei, TaiwanDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei City, TaiwanInstitute of Clinical Medicine, National Yang-Ming University, Taipei, TaiwanDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei City, TaiwanInstitute of Clinical Medicine, National Yang-Ming University, Taipei, TaiwanDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei City, TaiwanInstitute of Clinical Medicine, National Yang-Ming University, Taipei, TaiwanDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei City, TaiwanInstitute of Clinical Medicine, National Yang-Ming University, Taipei, TaiwanDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei City, TaiwanInstitute of Clinical Medicine, National Yang-Ming University, Taipei, TaiwanDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei City, TaiwanDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei City, TaiwanDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei City, TaiwanDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei City, TaiwanDepartment of Cardiology, Taichung Veterans General Hospital, Taichung, TaiwanDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei City, TaiwanDepartment of Cardiology, Serdang Hospital, Selangor, MalaysiaDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei City, TaiwanSection of Clinical Cardiac Electrophysiology, Heart Institute, St. Luke’s Medical Center – Global City, Taguig City, PhilippinesDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei City, TaiwanArrhythmia Treatment Department, Cho Ray Hospital, Ho Chi Minh City, VietnamDivision of Cardiology, Department of Medicine, Heart Rhythm Center, Taipei Veterans General Hospital, Taipei City, TaiwanInstitute of Clinical Medicine, National Yang-Ming University, Taipei, TaiwanDepartment of Cardiology, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Medicine, National Chung Hsing University, Taichung, TaiwanIntroductionSignal-averaged electrocardiography (SAECG) provides diagnostic and prognostic information regarding cardiac diseases. However, its value in other nonischemic cardiomyopathies (NICMs) remains unclear. This study aimed to investigate the role of SAECG in patients with NICM.Methods and resultsThis retrospective study included consecutive patients with NICM who underwent SAECG, biventricular substrate mapping, and ablation for ventricular arrhythmia (VA). Patients with baseline ventricular conduction disturbances were excluded. Patients who fulfilled at least one SAECG criterion were categorized into Group 1, and the other patients were categorized into Group 2. Baseline and ventricular substrate characteristics were compared between the two groups. The study included 58 patients (39 men, mean age 50.4 ± 15.5 years), with 34 and 24 patients in Groups 1 and 2, respectively. Epicardial mapping was performed in eight (23.5%) and six patients (25.0%) in Groups 1 and 2 (p = 0.897), respectively. Patients in Group 1 had a more extensive right ventricular (RV) low-voltage zone (LVZ) and scar area than those in Group 2. Group 1 had a larger epicardial LVZ than Group 2. Epicardial late potentials were more frequent in Group 1 than in Group 2. There were more arrhythmogenic foci within the RV outflow tract in Group 1 than in Group 2. There was no significant difference in long-term VA recurrence.ConclusionIn our NICM population, a positive SAECG was associated with a larger RV endocardial scar, epicardial scar/late potentials, and a higher incidence of arrhythmogenic foci in the RV outflow tract.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1306055/fullsignal-averaged electrocardiographynonischemic cardiomyopathyventricular arrhythmiaright ventricleepicardium |
| spellingShingle | Dinh Son Ngoc Nguyen Dinh Son Ngoc Nguyen Chin-Yu Lin Chin-Yu Lin Fa-Po Chung Fa-Po Chung Ting-Yung Chang Ting-Yung Chang Li-Wei Lo Li-Wei Lo Yenn-Jiang Lin Yenn-Jiang Lin Shih-Lin Chang Shih-Lin Chang Yu-Feng Hu Yu-Feng Hu Ta-Chuan Tuan Ta-Chuan Tuan Tze-Fan Chao Tze-Fan Chao Jo-Nan Liao Jo-Nan Liao Ling Kuo Ling Kuo Chih-Min Liu Chih-Min Liu Shin-Huei Liu Shin-Huei Liu Cheng-I Wu Cheng-I Wu Ming-Jen Kuo Guan-Yi Li Yu-Shan Huang Shang-Ju Wu Shang-Ju Wu Yoon Kee Siow Yoon Kee Siow Jose Antonio L. Bautista Jose Antonio L. Bautista Dat Tran Cao Dat Tran Cao Shih-Ann Chen Shih-Ann Chen Shih-Ann Chen Shih-Ann Chen Signal-averaged electrocardiography as a noninvasive tool for evaluating the ventricular substrate in patients with nonischemic cardiomyopathy: reassessment of an old tool Frontiers in Cardiovascular Medicine signal-averaged electrocardiography nonischemic cardiomyopathy ventricular arrhythmia right ventricle epicardium |
| title | Signal-averaged electrocardiography as a noninvasive tool for evaluating the ventricular substrate in patients with nonischemic cardiomyopathy: reassessment of an old tool |
| title_full | Signal-averaged electrocardiography as a noninvasive tool for evaluating the ventricular substrate in patients with nonischemic cardiomyopathy: reassessment of an old tool |
| title_fullStr | Signal-averaged electrocardiography as a noninvasive tool for evaluating the ventricular substrate in patients with nonischemic cardiomyopathy: reassessment of an old tool |
| title_full_unstemmed | Signal-averaged electrocardiography as a noninvasive tool for evaluating the ventricular substrate in patients with nonischemic cardiomyopathy: reassessment of an old tool |
| title_short | Signal-averaged electrocardiography as a noninvasive tool for evaluating the ventricular substrate in patients with nonischemic cardiomyopathy: reassessment of an old tool |
| title_sort | signal averaged electrocardiography as a noninvasive tool for evaluating the ventricular substrate in patients with nonischemic cardiomyopathy reassessment of an old tool |
| topic | signal-averaged electrocardiography nonischemic cardiomyopathy ventricular arrhythmia right ventricle epicardium |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1306055/full |
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