Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte and Monocyte-to-Lymphocyte Ratio in Bipolar Disorder
Background: Several inflammatory hypotheses have been suggested to explain the etiopathogenesis of bipolar disorder (BD) and its different phases. Neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), and monocyte-to-lymphocyte (MLR) ratios have been proposed as potential peripheral biomarke...
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| Format: | Article |
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MDPI AG
2021-01-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/1/58 |
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| author | Laura Fusar-Poli Antimo Natale Andrea Amerio Patriciu Cimpoesu Pietro Grimaldi Filioli Eugenio Aguglia Mario Amore Gianluca Serafini Andrea Aguglia |
| author_facet | Laura Fusar-Poli Antimo Natale Andrea Amerio Patriciu Cimpoesu Pietro Grimaldi Filioli Eugenio Aguglia Mario Amore Gianluca Serafini Andrea Aguglia |
| author_sort | Laura Fusar-Poli |
| collection | DOAJ |
| description | Background: Several inflammatory hypotheses have been suggested to explain the etiopathogenesis of bipolar disorder (BD) and its different phases. Neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), and monocyte-to-lymphocyte (MLR) ratios have been proposed as potential peripheral biomarkers of mood episodes. Methods: We recruited 294 patients affected by BD, of which 143 were experiencing a (hypo)manic episode and 151 were in a depressive phase. A blood sample was drawn to perform a complete blood count. NLR, PLR, and MLR were subsequently calculated. A <i>t</i>-test was performed to evaluate differences in blood cell counts between depressed and (hypo)manic patients and a regression model was then computed. Results: Mean values of neutrophils, platelets, mean platelet volume, NLR, PLR, and MLR were significantly higher in (hypo)manic than depressed individuals. Logistic regression showed that PLR may represent an independent predictor of (hypo)mania. Conclusions: Altered inflammatory indexes, particularly PLR, may explain the onset and recurrence of (hypo)manic episodes in patients with BD. As inflammatory ratios represent economical and accessible markers of inflammation, further studies should be implemented to better elucidate their role as peripheral biomarkers of BD mood episodes. |
| first_indexed | 2024-03-10T13:27:10Z |
| format | Article |
| id | doaj.art-7fe2cdc35b7049b2955315b4f981732a |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T13:27:10Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-7fe2cdc35b7049b2955315b4f981732a2023-11-21T08:43:36ZengMDPI AGBrain Sciences2076-34252021-01-011115810.3390/brainsci11010058Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte and Monocyte-to-Lymphocyte Ratio in Bipolar DisorderLaura Fusar-Poli0Antimo Natale1Andrea Amerio2Patriciu Cimpoesu3Pietro Grimaldi Filioli4Eugenio Aguglia5Mario Amore6Gianluca Serafini7Andrea Aguglia8Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Catania, 95124 Catania, ItalyPsychiatry Unit, Department of Clinical and Experimental Medicine, University of Catania, 95124 Catania, ItalyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, 16126 Genoa, ItalyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, 16126 Genoa, ItalyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, 16126 Genoa, ItalyPsychiatry Unit, Department of Clinical and Experimental Medicine, University of Catania, 95124 Catania, ItalyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, 16126 Genoa, ItalyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, 16126 Genoa, ItalyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, 16126 Genoa, ItalyBackground: Several inflammatory hypotheses have been suggested to explain the etiopathogenesis of bipolar disorder (BD) and its different phases. Neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), and monocyte-to-lymphocyte (MLR) ratios have been proposed as potential peripheral biomarkers of mood episodes. Methods: We recruited 294 patients affected by BD, of which 143 were experiencing a (hypo)manic episode and 151 were in a depressive phase. A blood sample was drawn to perform a complete blood count. NLR, PLR, and MLR were subsequently calculated. A <i>t</i>-test was performed to evaluate differences in blood cell counts between depressed and (hypo)manic patients and a regression model was then computed. Results: Mean values of neutrophils, platelets, mean platelet volume, NLR, PLR, and MLR were significantly higher in (hypo)manic than depressed individuals. Logistic regression showed that PLR may represent an independent predictor of (hypo)mania. Conclusions: Altered inflammatory indexes, particularly PLR, may explain the onset and recurrence of (hypo)manic episodes in patients with BD. As inflammatory ratios represent economical and accessible markers of inflammation, further studies should be implemented to better elucidate their role as peripheral biomarkers of BD mood episodes.https://www.mdpi.com/2076-3425/11/1/58inflammatory ratioplateletmonocytelymphocyteblood cell countsinflammation |
| spellingShingle | Laura Fusar-Poli Antimo Natale Andrea Amerio Patriciu Cimpoesu Pietro Grimaldi Filioli Eugenio Aguglia Mario Amore Gianluca Serafini Andrea Aguglia Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte and Monocyte-to-Lymphocyte Ratio in Bipolar Disorder Brain Sciences inflammatory ratio platelet monocyte lymphocyte blood cell counts inflammation |
| title | Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte and Monocyte-to-Lymphocyte Ratio in Bipolar Disorder |
| title_full | Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte and Monocyte-to-Lymphocyte Ratio in Bipolar Disorder |
| title_fullStr | Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte and Monocyte-to-Lymphocyte Ratio in Bipolar Disorder |
| title_full_unstemmed | Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte and Monocyte-to-Lymphocyte Ratio in Bipolar Disorder |
| title_short | Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte and Monocyte-to-Lymphocyte Ratio in Bipolar Disorder |
| title_sort | neutrophil to lymphocyte platelet to lymphocyte and monocyte to lymphocyte ratio in bipolar disorder |
| topic | inflammatory ratio platelet monocyte lymphocyte blood cell counts inflammation |
| url | https://www.mdpi.com/2076-3425/11/1/58 |
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