Efficacy analysis of a novel thermochemotherapy scheme with pirarubicin for intermediate- and high-risk nonmuscle-invasive bladder cancer: a single-institution nonrandomized concurrent controlled trial
Objective: To compare the efficacy and safety of a novel thermochemotherapy scheme and the instillation of pirarubicin (THP) without hyperthermia in patients with intermediate- and high-risk nonmuscle-invasive bladder cancer (NMIBC). Materials and methods: Between June 2012 and December 2016, 300 pa...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-01-01
|
| Series: | International Journal of Hyperthermia |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/02656736.2019.1646929 |
| _version_ | 1818142309216157696 |
|---|---|
| author | Jun Zhou Linlin Li Xing Li Qian Yu Shaowei Cui Kunpeng Shu Jianjun Liu Jie Liu Degang Ding Tao Du |
| author_facet | Jun Zhou Linlin Li Xing Li Qian Yu Shaowei Cui Kunpeng Shu Jianjun Liu Jie Liu Degang Ding Tao Du |
| author_sort | Jun Zhou |
| collection | DOAJ |
| description | Objective: To compare the efficacy and safety of a novel thermochemotherapy scheme and the instillation of pirarubicin (THP) without hyperthermia in patients with intermediate- and high-risk nonmuscle-invasive bladder cancer (NMIBC). Materials and methods: Between June 2012 and December 2016, 300 patients with urothelial carcinoma of the bladder undergoing intravesical adjuvant therapy with THP after transurethral resection of bladder tumors (TURBT) were enrolled in the study. These patients were divided into the CTHC group (thermochemotherapy composed of three consecutive sessions in which only the second hyperthermia was combined with THP, followed by intravesical instillation with THP without using hyperthermia) and the THP group (instillation of THP without hyperthermia). Cystoscopy and urinary cytology were repeated every 3 months. The primary endpoint was 24-month recurrence-free survival (RFS). Secondary endpoints included 24-month progression-free survival (PFS) and adverse event (AE) rates. Results: Baseline characteristics of the CTHC (n = 76) and THP (n = 85) groups were well-balanced. The 24-month RFS was 82.9% in the CTHC group and 63.5% in the THP group (log-rank p = .008). A significantly higher percentage of patients in the CTHC group achieved PFS than in the THP group (97.4% versus 87.1%; log-rank p = .011). There was no significant difference in AEs between the two groups (p > .05). Based on Cox proportional hazards models, CTHC was the only factor that contributed independently to improved RFS (hazard ratio, 0.422; 95% confidence interval, 0.214–0.835; p = .013). Conclusion: The CTHC scheme is a safe and effective adjuvant treatment option after TURBT for patients with intermediate- and high-risk NMIBC. |
| first_indexed | 2024-12-11T11:13:43Z |
| format | Article |
| id | doaj.art-7fe34a26323f4631bc40af782f257531 |
| institution | Directory Open Access Journal |
| issn | 0265-6736 1464-5157 |
| language | English |
| last_indexed | 2024-12-11T11:13:43Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj.art-7fe34a26323f4631bc40af782f2575312022-12-22T01:09:25ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572019-01-0136186787410.1080/02656736.2019.16469291646929Efficacy analysis of a novel thermochemotherapy scheme with pirarubicin for intermediate- and high-risk nonmuscle-invasive bladder cancer: a single-institution nonrandomized concurrent controlled trialJun Zhou0Linlin Li1Xing Li2Qian Yu3Shaowei Cui4Kunpeng Shu5Jianjun Liu6Jie Liu7Degang Ding8Tao Du9Henan University People's HospitalHenan Provincial People's HospitalZhengzhou University People's HospitalHenan University People's HospitalHenan University People's HospitalHenan Provincial People's HospitalHenan University People's HospitalHenan University People's HospitalHenan University People's HospitalHenan University People's HospitalObjective: To compare the efficacy and safety of a novel thermochemotherapy scheme and the instillation of pirarubicin (THP) without hyperthermia in patients with intermediate- and high-risk nonmuscle-invasive bladder cancer (NMIBC). Materials and methods: Between June 2012 and December 2016, 300 patients with urothelial carcinoma of the bladder undergoing intravesical adjuvant therapy with THP after transurethral resection of bladder tumors (TURBT) were enrolled in the study. These patients were divided into the CTHC group (thermochemotherapy composed of three consecutive sessions in which only the second hyperthermia was combined with THP, followed by intravesical instillation with THP without using hyperthermia) and the THP group (instillation of THP without hyperthermia). Cystoscopy and urinary cytology were repeated every 3 months. The primary endpoint was 24-month recurrence-free survival (RFS). Secondary endpoints included 24-month progression-free survival (PFS) and adverse event (AE) rates. Results: Baseline characteristics of the CTHC (n = 76) and THP (n = 85) groups were well-balanced. The 24-month RFS was 82.9% in the CTHC group and 63.5% in the THP group (log-rank p = .008). A significantly higher percentage of patients in the CTHC group achieved PFS than in the THP group (97.4% versus 87.1%; log-rank p = .011). There was no significant difference in AEs between the two groups (p > .05). Based on Cox proportional hazards models, CTHC was the only factor that contributed independently to improved RFS (hazard ratio, 0.422; 95% confidence interval, 0.214–0.835; p = .013). Conclusion: The CTHC scheme is a safe and effective adjuvant treatment option after TURBT for patients with intermediate- and high-risk NMIBC.http://dx.doi.org/10.1080/02656736.2019.1646929nonmuscle-invasive bladder cancer (nmibc)pirarubicin (thp)hyperthermiaintravesical chemotherapythermochemotherapy |
| spellingShingle | Jun Zhou Linlin Li Xing Li Qian Yu Shaowei Cui Kunpeng Shu Jianjun Liu Jie Liu Degang Ding Tao Du Efficacy analysis of a novel thermochemotherapy scheme with pirarubicin for intermediate- and high-risk nonmuscle-invasive bladder cancer: a single-institution nonrandomized concurrent controlled trial International Journal of Hyperthermia nonmuscle-invasive bladder cancer (nmibc) pirarubicin (thp) hyperthermia intravesical chemotherapy thermochemotherapy |
| title | Efficacy analysis of a novel thermochemotherapy scheme with pirarubicin for intermediate- and high-risk nonmuscle-invasive bladder cancer: a single-institution nonrandomized concurrent controlled trial |
| title_full | Efficacy analysis of a novel thermochemotherapy scheme with pirarubicin for intermediate- and high-risk nonmuscle-invasive bladder cancer: a single-institution nonrandomized concurrent controlled trial |
| title_fullStr | Efficacy analysis of a novel thermochemotherapy scheme with pirarubicin for intermediate- and high-risk nonmuscle-invasive bladder cancer: a single-institution nonrandomized concurrent controlled trial |
| title_full_unstemmed | Efficacy analysis of a novel thermochemotherapy scheme with pirarubicin for intermediate- and high-risk nonmuscle-invasive bladder cancer: a single-institution nonrandomized concurrent controlled trial |
| title_short | Efficacy analysis of a novel thermochemotherapy scheme with pirarubicin for intermediate- and high-risk nonmuscle-invasive bladder cancer: a single-institution nonrandomized concurrent controlled trial |
| title_sort | efficacy analysis of a novel thermochemotherapy scheme with pirarubicin for intermediate and high risk nonmuscle invasive bladder cancer a single institution nonrandomized concurrent controlled trial |
| topic | nonmuscle-invasive bladder cancer (nmibc) pirarubicin (thp) hyperthermia intravesical chemotherapy thermochemotherapy |
| url | http://dx.doi.org/10.1080/02656736.2019.1646929 |
| work_keys_str_mv | AT junzhou efficacyanalysisofanovelthermochemotherapyschemewithpirarubicinforintermediateandhighrisknonmuscleinvasivebladdercancerasingleinstitutionnonrandomizedconcurrentcontrolledtrial AT linlinli efficacyanalysisofanovelthermochemotherapyschemewithpirarubicinforintermediateandhighrisknonmuscleinvasivebladdercancerasingleinstitutionnonrandomizedconcurrentcontrolledtrial AT xingli efficacyanalysisofanovelthermochemotherapyschemewithpirarubicinforintermediateandhighrisknonmuscleinvasivebladdercancerasingleinstitutionnonrandomizedconcurrentcontrolledtrial AT qianyu efficacyanalysisofanovelthermochemotherapyschemewithpirarubicinforintermediateandhighrisknonmuscleinvasivebladdercancerasingleinstitutionnonrandomizedconcurrentcontrolledtrial AT shaoweicui efficacyanalysisofanovelthermochemotherapyschemewithpirarubicinforintermediateandhighrisknonmuscleinvasivebladdercancerasingleinstitutionnonrandomizedconcurrentcontrolledtrial AT kunpengshu efficacyanalysisofanovelthermochemotherapyschemewithpirarubicinforintermediateandhighrisknonmuscleinvasivebladdercancerasingleinstitutionnonrandomizedconcurrentcontrolledtrial AT jianjunliu efficacyanalysisofanovelthermochemotherapyschemewithpirarubicinforintermediateandhighrisknonmuscleinvasivebladdercancerasingleinstitutionnonrandomizedconcurrentcontrolledtrial AT jieliu efficacyanalysisofanovelthermochemotherapyschemewithpirarubicinforintermediateandhighrisknonmuscleinvasivebladdercancerasingleinstitutionnonrandomizedconcurrentcontrolledtrial AT degangding efficacyanalysisofanovelthermochemotherapyschemewithpirarubicinforintermediateandhighrisknonmuscleinvasivebladdercancerasingleinstitutionnonrandomizedconcurrentcontrolledtrial AT taodu efficacyanalysisofanovelthermochemotherapyschemewithpirarubicinforintermediateandhighrisknonmuscleinvasivebladdercancerasingleinstitutionnonrandomizedconcurrentcontrolledtrial |