COVID-19 Infection and Neuropathological Features
The pathology associated with COVID-19 infection is progressively being revealed. Recent postmortem assessments have revealed acute airway inflammation as well as diffuse alveolar damage, which bears resemblance to severe acute respiratory syndromes induced by both SARS-CoV and MERS-CoV infections....
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Medicines |
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| Online Access: | https://www.mdpi.com/2305-6320/8/10/59 |
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| author | Leonardo Freire-de-Lima Aline Miranda Scovino Leonardo Marques da Fonseca Camilla Cristie Barreto Menezes Carlos Antonio do Nascimento Santos Marco Edilson Freire de Lima Debora Decote-Ricardo Matheus Freire-de-Lima Kelli Monteiro da Costa Jhenifer Santos dos Reis Marcos André Rodrigues da Costa Santos Celio Geraldo Freire-de-Lima Alexandre Morrot |
| author_facet | Leonardo Freire-de-Lima Aline Miranda Scovino Leonardo Marques da Fonseca Camilla Cristie Barreto Menezes Carlos Antonio do Nascimento Santos Marco Edilson Freire de Lima Debora Decote-Ricardo Matheus Freire-de-Lima Kelli Monteiro da Costa Jhenifer Santos dos Reis Marcos André Rodrigues da Costa Santos Celio Geraldo Freire-de-Lima Alexandre Morrot |
| author_sort | Leonardo Freire-de-Lima |
| collection | DOAJ |
| description | The pathology associated with COVID-19 infection is progressively being revealed. Recent postmortem assessments have revealed acute airway inflammation as well as diffuse alveolar damage, which bears resemblance to severe acute respiratory syndromes induced by both SARS-CoV and MERS-CoV infections. Although recent papers have highlighted some neuropathologies associated with COVID-19 infection, little is known about this topic of great importance in the area of public health. Here, we discuss how neuroinflammation related to COVID-19 could be triggered by direct viral neuroinvasion and/or cytokine release over the course of the infection. |
| first_indexed | 2024-03-10T06:24:04Z |
| format | Article |
| id | doaj.art-7fe40826d7ef4d1b98bb6d3706a7ac36 |
| institution | Directory Open Access Journal |
| issn | 2305-6320 |
| language | English |
| last_indexed | 2024-03-10T06:24:04Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicines |
| spelling | doaj.art-7fe40826d7ef4d1b98bb6d3706a7ac362023-11-22T19:05:34ZengMDPI AGMedicines2305-63202021-10-018105910.3390/medicines8100059COVID-19 Infection and Neuropathological FeaturesLeonardo Freire-de-Lima0Aline Miranda Scovino1Leonardo Marques da Fonseca2Camilla Cristie Barreto Menezes3Carlos Antonio do Nascimento Santos4Marco Edilson Freire de Lima5Debora Decote-Ricardo6Matheus Freire-de-Lima7Kelli Monteiro da Costa8Jhenifer Santos dos Reis9Marcos André Rodrigues da Costa Santos10Celio Geraldo Freire-de-Lima11Alexandre Morrot12Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, BrazilInstituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, BrazilInstituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, BrazilInstituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro 21040-360, BrazilInstituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, BrazilDepartamento de Química Orgânica, Instituto de Química, Universidade Federal Rural do Rio de Janeiro, Rio de Janeiro 23890-000, BrazilDepartamento de Microbiologia e Imunologia Veterinária, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Rio de Janeiro 23890-000, BrazilInstituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, BrazilInstituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, BrazilInstituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, BrazilInstituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, BrazilInstituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-170, BrazilInstituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro 21040-360, BrazilThe pathology associated with COVID-19 infection is progressively being revealed. Recent postmortem assessments have revealed acute airway inflammation as well as diffuse alveolar damage, which bears resemblance to severe acute respiratory syndromes induced by both SARS-CoV and MERS-CoV infections. Although recent papers have highlighted some neuropathologies associated with COVID-19 infection, little is known about this topic of great importance in the area of public health. Here, we discuss how neuroinflammation related to COVID-19 could be triggered by direct viral neuroinvasion and/or cytokine release over the course of the infection.https://www.mdpi.com/2305-6320/8/10/59COVID-19 infectionneuropathologyautoantibodiesneuroinflammation |
| spellingShingle | Leonardo Freire-de-Lima Aline Miranda Scovino Leonardo Marques da Fonseca Camilla Cristie Barreto Menezes Carlos Antonio do Nascimento Santos Marco Edilson Freire de Lima Debora Decote-Ricardo Matheus Freire-de-Lima Kelli Monteiro da Costa Jhenifer Santos dos Reis Marcos André Rodrigues da Costa Santos Celio Geraldo Freire-de-Lima Alexandre Morrot COVID-19 Infection and Neuropathological Features Medicines COVID-19 infection neuropathology autoantibodies neuroinflammation |
| title | COVID-19 Infection and Neuropathological Features |
| title_full | COVID-19 Infection and Neuropathological Features |
| title_fullStr | COVID-19 Infection and Neuropathological Features |
| title_full_unstemmed | COVID-19 Infection and Neuropathological Features |
| title_short | COVID-19 Infection and Neuropathological Features |
| title_sort | covid 19 infection and neuropathological features |
| topic | COVID-19 infection neuropathology autoantibodies neuroinflammation |
| url | https://www.mdpi.com/2305-6320/8/10/59 |
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