Site-Specific Transient Receptor Potential Channel Mechanisms and Their Characteristics for Targeted Chronic Itch Treatment
Chronic itch is a debilitating condition with limited treatment options, severely affecting quality of life. The identification of pruriceptors has sparked a growing interest in the therapeutic potential of TRP channels in the context of itch. In this regard, we provided a comprehensive overview of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/14/1/107 |
| _version_ | 1797344559142797312 |
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| author | Eun Jin Go Ji Yeon Lee Yong Ho Kim Chul-Kyu Park |
| author_facet | Eun Jin Go Ji Yeon Lee Yong Ho Kim Chul-Kyu Park |
| author_sort | Eun Jin Go |
| collection | DOAJ |
| description | Chronic itch is a debilitating condition with limited treatment options, severely affecting quality of life. The identification of pruriceptors has sparked a growing interest in the therapeutic potential of TRP channels in the context of itch. In this regard, we provided a comprehensive overview of the site-specific expression of TRP channels and their associated functions in response to a range of pruritogens. Although several potent antipruritic compounds that target specific TRP channels have been developed and have demonstrated efficacy in various chronic itch conditions through experimental means, a more thorough understanding of the potential for adverse effects or interactions with other TRP channels or GPCRs is necessary to develop novel and selective therapeutics that target TRP channels for treating chronic itch. This review focuses on the mechanism of itch associated with TRP channels at specific sites, from the skin to the sensory neuron, with the aim of suggesting specific therapeutic targets for treating this condition. |
| first_indexed | 2024-03-08T11:04:29Z |
| format | Article |
| id | doaj.art-7fe5e4668d1b4b5c93a9ce3b5ae1e50b |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-08T11:04:29Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-7fe5e4668d1b4b5c93a9ce3b5ae1e50b2024-01-26T15:21:10ZengMDPI AGBiomolecules2218-273X2024-01-0114110710.3390/biom14010107Site-Specific Transient Receptor Potential Channel Mechanisms and Their Characteristics for Targeted Chronic Itch TreatmentEun Jin Go0Ji Yeon Lee1Yong Ho Kim2Chul-Kyu Park3Gachon Pain Center and Department of Physiology, College of Medicine, Gachon University, Incheon 21999, Republic of KoreaDepartment of Anesthesiology and Pain Medicine, Gil Medical Center, Gachon University, Incheon 21565, Republic of KoreaGachon Pain Center and Department of Physiology, College of Medicine, Gachon University, Incheon 21999, Republic of KoreaGachon Pain Center and Department of Physiology, College of Medicine, Gachon University, Incheon 21999, Republic of KoreaChronic itch is a debilitating condition with limited treatment options, severely affecting quality of life. The identification of pruriceptors has sparked a growing interest in the therapeutic potential of TRP channels in the context of itch. In this regard, we provided a comprehensive overview of the site-specific expression of TRP channels and their associated functions in response to a range of pruritogens. Although several potent antipruritic compounds that target specific TRP channels have been developed and have demonstrated efficacy in various chronic itch conditions through experimental means, a more thorough understanding of the potential for adverse effects or interactions with other TRP channels or GPCRs is necessary to develop novel and selective therapeutics that target TRP channels for treating chronic itch. This review focuses on the mechanism of itch associated with TRP channels at specific sites, from the skin to the sensory neuron, with the aim of suggesting specific therapeutic targets for treating this condition.https://www.mdpi.com/2218-273X/14/1/107chronic itchTRP channelsskinsensory neurons |
| spellingShingle | Eun Jin Go Ji Yeon Lee Yong Ho Kim Chul-Kyu Park Site-Specific Transient Receptor Potential Channel Mechanisms and Their Characteristics for Targeted Chronic Itch Treatment Biomolecules chronic itch TRP channels skin sensory neurons |
| title | Site-Specific Transient Receptor Potential Channel Mechanisms and Their Characteristics for Targeted Chronic Itch Treatment |
| title_full | Site-Specific Transient Receptor Potential Channel Mechanisms and Their Characteristics for Targeted Chronic Itch Treatment |
| title_fullStr | Site-Specific Transient Receptor Potential Channel Mechanisms and Their Characteristics for Targeted Chronic Itch Treatment |
| title_full_unstemmed | Site-Specific Transient Receptor Potential Channel Mechanisms and Their Characteristics for Targeted Chronic Itch Treatment |
| title_short | Site-Specific Transient Receptor Potential Channel Mechanisms and Their Characteristics for Targeted Chronic Itch Treatment |
| title_sort | site specific transient receptor potential channel mechanisms and their characteristics for targeted chronic itch treatment |
| topic | chronic itch TRP channels skin sensory neurons |
| url | https://www.mdpi.com/2218-273X/14/1/107 |
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