A multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis.
Successful mass drug administration (MDA) campaigns have brought several countries near the point of Lymphatic Filariasis (LF) elimination. A diagnostic tool is needed to determine when the prevalence levels have decreased to a point that MDA campaigns can be discontinued without the threat of recru...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | http://europepmc.org/articles/PMC3260316?pdf=render |
| _version_ | 1819103543884251136 |
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| author | Katherine Gass Madsen V E Beau de Rochars Daniel Boakye Mark Bradley Peter U Fischer John Gyapong Makoto Itoh Nese Ituaso-Conway Hayley Joseph Dominique Kyelem Sandra J Laney Anne-Marie Legrand Tilaka S Liyanage Wayne Melrose Khalfan Mohammed Nils Pilotte Eric A Ottesen Catherine Plichart Kapa Ramaiah Ramakrishna U Rao Jeffrey Talbot Gary J Weil Steven A Williams Kimberly Y Won Patrick Lammie |
| author_facet | Katherine Gass Madsen V E Beau de Rochars Daniel Boakye Mark Bradley Peter U Fischer John Gyapong Makoto Itoh Nese Ituaso-Conway Hayley Joseph Dominique Kyelem Sandra J Laney Anne-Marie Legrand Tilaka S Liyanage Wayne Melrose Khalfan Mohammed Nils Pilotte Eric A Ottesen Catherine Plichart Kapa Ramaiah Ramakrishna U Rao Jeffrey Talbot Gary J Weil Steven A Williams Kimberly Y Won Patrick Lammie |
| author_sort | Katherine Gass |
| collection | DOAJ |
| description | Successful mass drug administration (MDA) campaigns have brought several countries near the point of Lymphatic Filariasis (LF) elimination. A diagnostic tool is needed to determine when the prevalence levels have decreased to a point that MDA campaigns can be discontinued without the threat of recrudescence. A six-country study was conducted assessing the performance of seven diagnostic tests, including tests for microfilariae (blood smear, PCR), parasite antigen (ICT, Og4C3) and antifilarial antibody (Bm14, PanLF, Urine SXP). One community survey and one school survey were performed in each country. A total of 8,513 people from the six countries participated in the study, 6,443 through community surveys and 2,070 through school surveys. Specimens from these participants were used to conduct 49,585 diagnostic tests. Each test was seen to have both positive and negative attributes, but overall, the ICT test was found to be 76% sensitive at detecting microfilaremia and 93% specific at identifying individuals negative for both microfilariae and antifilarial antibody; the Og4C3 test was 87% sensitive and 95% specific. We conclude, however, that the ICT should be the primary tool recommended for decision-making about stopping MDAs. As a point-of-care diagnostic, the ICT is relatively inexpensive, requires no laboratory equipment, has satisfactory sensitivity and specificity and can be processed in 10 minutes-qualities consistent with programmatic use. Og4C3 provides a satisfactory laboratory-based diagnostic alternative. |
| first_indexed | 2024-12-22T01:52:08Z |
| format | Article |
| id | doaj.art-7fe814cce98b4e9d90972485aa898143 |
| institution | Directory Open Access Journal |
| issn | 1935-2735 |
| language | English |
| last_indexed | 2024-12-22T01:52:08Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-7fe814cce98b4e9d90972485aa8981432022-12-21T18:42:52ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27352012-01-0161e147910.1371/journal.pntd.0001479A multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis.Katherine GassMadsen V E Beau de RocharsDaniel BoakyeMark BradleyPeter U FischerJohn GyapongMakoto ItohNese Ituaso-ConwayHayley JosephDominique KyelemSandra J LaneyAnne-Marie LegrandTilaka S LiyanageWayne MelroseKhalfan MohammedNils PilotteEric A OttesenCatherine PlichartKapa RamaiahRamakrishna U RaoJeffrey TalbotGary J WeilSteven A WilliamsKimberly Y WonPatrick LammieSuccessful mass drug administration (MDA) campaigns have brought several countries near the point of Lymphatic Filariasis (LF) elimination. A diagnostic tool is needed to determine when the prevalence levels have decreased to a point that MDA campaigns can be discontinued without the threat of recrudescence. A six-country study was conducted assessing the performance of seven diagnostic tests, including tests for microfilariae (blood smear, PCR), parasite antigen (ICT, Og4C3) and antifilarial antibody (Bm14, PanLF, Urine SXP). One community survey and one school survey were performed in each country. A total of 8,513 people from the six countries participated in the study, 6,443 through community surveys and 2,070 through school surveys. Specimens from these participants were used to conduct 49,585 diagnostic tests. Each test was seen to have both positive and negative attributes, but overall, the ICT test was found to be 76% sensitive at detecting microfilaremia and 93% specific at identifying individuals negative for both microfilariae and antifilarial antibody; the Og4C3 test was 87% sensitive and 95% specific. We conclude, however, that the ICT should be the primary tool recommended for decision-making about stopping MDAs. As a point-of-care diagnostic, the ICT is relatively inexpensive, requires no laboratory equipment, has satisfactory sensitivity and specificity and can be processed in 10 minutes-qualities consistent with programmatic use. Og4C3 provides a satisfactory laboratory-based diagnostic alternative.http://europepmc.org/articles/PMC3260316?pdf=render |
| spellingShingle | Katherine Gass Madsen V E Beau de Rochars Daniel Boakye Mark Bradley Peter U Fischer John Gyapong Makoto Itoh Nese Ituaso-Conway Hayley Joseph Dominique Kyelem Sandra J Laney Anne-Marie Legrand Tilaka S Liyanage Wayne Melrose Khalfan Mohammed Nils Pilotte Eric A Ottesen Catherine Plichart Kapa Ramaiah Ramakrishna U Rao Jeffrey Talbot Gary J Weil Steven A Williams Kimberly Y Won Patrick Lammie A multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis. PLoS Neglected Tropical Diseases |
| title | A multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis. |
| title_full | A multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis. |
| title_fullStr | A multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis. |
| title_full_unstemmed | A multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis. |
| title_short | A multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis. |
| title_sort | multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis |
| url | http://europepmc.org/articles/PMC3260316?pdf=render |
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