A case report of sudden cardiac arrest and torsade de pointes induced by the second-generation tyrosine kinase inhibitor dasatinib combined with fluconazole
A-41-year-old man diagnosed with acute myeloid leukemia (AML) survived dasatinib + fluconazole drug-induced long QT syndrome, sudden cardiac arrest, and torsade de pointes. Drug features and interaction jointly contributed to the whole process. Therefore, appropriate attention to drug interaction an...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.984572/full |
| _version_ | 1797924652933185536 |
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| author | Yuting Yuan Chunjian Wang Hongying Yao |
| author_facet | Yuting Yuan Chunjian Wang Hongying Yao |
| author_sort | Yuting Yuan |
| collection | DOAJ |
| description | A-41-year-old man diagnosed with acute myeloid leukemia (AML) survived dasatinib + fluconazole drug-induced long QT syndrome, sudden cardiac arrest, and torsade de pointes. Drug features and interaction jointly contributed to the whole process. Therefore, appropriate attention to drug interaction and close ECG monitoring are highly recommended for hospitalized patients, especially for those undergoing multi-drug regimens. |
| first_indexed | 2024-04-10T15:04:15Z |
| format | Article |
| id | doaj.art-7fe8d6152fd6463ba833e4b6ab06038e |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-10T15:04:15Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-7fe8d6152fd6463ba833e4b6ab06038e2023-02-15T07:45:40ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-02-011010.3389/fcvm.2023.984572984572A case report of sudden cardiac arrest and torsade de pointes induced by the second-generation tyrosine kinase inhibitor dasatinib combined with fluconazoleYuting Yuan0Chunjian Wang1Hongying Yao2Department of Cardiology, Peking University International Hospital, Beijing, ChinaDepartment of Hematology, Peking University International Hospital, Beijing, ChinaDepartment of Cardiology, Peking University International Hospital, Beijing, ChinaA-41-year-old man diagnosed with acute myeloid leukemia (AML) survived dasatinib + fluconazole drug-induced long QT syndrome, sudden cardiac arrest, and torsade de pointes. Drug features and interaction jointly contributed to the whole process. Therefore, appropriate attention to drug interaction and close ECG monitoring are highly recommended for hospitalized patients, especially for those undergoing multi-drug regimens.https://www.frontiersin.org/articles/10.3389/fcvm.2023.984572/fulldasatinibfluconazoledrug-induced long QT syndrometorsade de pointestyrosine kinase inhibitorsudden cardiac arrest |
| spellingShingle | Yuting Yuan Chunjian Wang Hongying Yao A case report of sudden cardiac arrest and torsade de pointes induced by the second-generation tyrosine kinase inhibitor dasatinib combined with fluconazole Frontiers in Cardiovascular Medicine dasatinib fluconazole drug-induced long QT syndrome torsade de pointes tyrosine kinase inhibitor sudden cardiac arrest |
| title | A case report of sudden cardiac arrest and torsade de pointes induced by the second-generation tyrosine kinase inhibitor dasatinib combined with fluconazole |
| title_full | A case report of sudden cardiac arrest and torsade de pointes induced by the second-generation tyrosine kinase inhibitor dasatinib combined with fluconazole |
| title_fullStr | A case report of sudden cardiac arrest and torsade de pointes induced by the second-generation tyrosine kinase inhibitor dasatinib combined with fluconazole |
| title_full_unstemmed | A case report of sudden cardiac arrest and torsade de pointes induced by the second-generation tyrosine kinase inhibitor dasatinib combined with fluconazole |
| title_short | A case report of sudden cardiac arrest and torsade de pointes induced by the second-generation tyrosine kinase inhibitor dasatinib combined with fluconazole |
| title_sort | case report of sudden cardiac arrest and torsade de pointes induced by the second generation tyrosine kinase inhibitor dasatinib combined with fluconazole |
| topic | dasatinib fluconazole drug-induced long QT syndrome torsade de pointes tyrosine kinase inhibitor sudden cardiac arrest |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.984572/full |
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