CX3CL1/CX3CR1 axis attenuates early brain injury via promoting the delivery of exosomal microRNA-124 from neuron to microglia after subarachnoid hemorrhage

CX3CL1/CX3CR1 axis attenuates early brain injury via promoting the delivery of exosomal microRNA-124 from neuron to microglia after subarachnoid hemorrhage

Abstract Background Microglial activation-mediated neuroinflammation is a major contributor to early brain injury (EBI) after subarachnoid hemorrhage (SAH). MicroRNA-124 (miR-124) is the most abundant miRNAs in the central nervous system (CNS) and plays a vital role in microglial activation by targe...

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Bibliographic Details
Main Authors: Xiao Chen, Ming Jiang, Haiying Li, Yang Wang, Haitao Shen, Xiang Li, Yunhai Zhang, Jiang Wu, Zhengquan Yu, Gang Chen
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Neuroinflammation
Subjects:
Subarachnoid hemorrhage
Early brain injury
CX3CL1
CX3CR1
Microglia
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s12974-020-01882-6

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