Synthesis and Antiproliferative Potential of Thiazole and 4-Thiazolidinone Containing Motifs as Dual Inhibitors of EGFR and BRAF<sup>V600E</sup>

Synthesis and Antiproliferative Potential of Thiazole and 4-Thiazolidinone Containing Motifs as Dual Inhibitors of EGFR and BRAF<sup>V600E</sup>

Thiazole and thiazolidinone recur in a wide range of biologically active compounds that reach different targets within the context of tumors and represent a promising starting point to access potential candidates for treating metastatic cancer. Therefore, searching for new lead compounds that show t...

Full description

Bibliographic Details
Main Authors:	Alaa A. Hassan, Nasr K. Mohamed, Ashraf A. Aly, Mohamed Ramadan, Hesham A. M. Gomaa, Ahmed T. Abdel-Aziz, Bahaa G. M. Youssif, Stefan Bräse, Olaf Fuhr
Format:	Article
Language:	English
Published:	MDPI AG 2023-12-01
Series:	Molecules
Subjects:	thiazole 4-thiazolidinone EGFR BRAF dual inhibitors anticancer
Online Access:	https://www.mdpi.com/1420-3049/28/24/7951

Similar Items

Thiazoles and Thiazolidinones as COX/LOX Inhibitors
by: Konstantinos Liaras, et al.
Published: (2018-03-01)

Thiazole-Bearing 4-Thiazolidinones as New Anticonvulsant Agents
by: Mariia Mishchenko, et al.
Published: (2020-03-01)

Synthesis and Structure Determination of Substituted Thiazole Derivatives as EGFR/BRAF<sup>V600E</sup> Dual Inhibitors Endowed with Antiproliferative Activity
by: Lamya H. Al-Wahaibi, et al.
Published: (2023-07-01)

Design and synthesis of new thiazolidinone/uracil derivatives as antiproliferative agents targeting EGFR and/or BRAFV600E
by: Mohammed B. Alshammari, et al.
Published: (2022-12-01)

Design, Synthesis, and Anti-Proliferative Action of Purine/Pteridine-Based Derivatives as Dual Inhibitors of EGFR and BRAF<sup>V600E</sup>
by: Samar A. El-Kalyoubi, et al.
Published: (2023-05-01)

The Potential of Thiazole Derivatives as Antimicrobial Agents
by: Shabnam Thakur, et al.
Published: (2022-11-01)

Quinazolin-4-one/3-cyanopyridin-2-one Hybrids as Dual Inhibitors of EGFR and BRAF<sup>V600E</sup>: Design, Synthesis, and Antiproliferative Activity
by: Lamya H. Al-Wahaibi, et al.
Published: (2023-10-01)

Discovery of 5-Methylthiazole-Thiazolidinone Conjugates as Potential Anti-Inflammatory Agents: Molecular Target Identification and In Silico Studies
by: Michelyne Haroun, et al.
Published: (2022-11-01)

Design, synthesis, docking and mechanistic studies of new thiazolyl/thiazolidinylpyrimidine-2,4-dione antiproliferative agents
by: Ashraf A. Aly, et al.
Published: (2023-04-01)

Design, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-<i>b</i>]indol-3-one Derivatives as Potent Inhibitors of EGFR<sup>T790M</sup>/BRAF<sup>V600E</sup> Pathways
by: Lamya H. Al-Wahaibi, et al.
Published: (2023-01-01)

Pyrano [2,3-d] thiazole: synthesis, reactions and biological applications
by: mohamed abdalrashid salem, et al.
Published: (2018-08-01)

Pyrano [2,3-d] thiazole: synthesis, reactions and biological applications
by: mohamed abdalrashid salem, et al.
Published: (2018-08-01)

Effects of Copper Chelation on BRAF<sup>V600E</sup> Positive Colon Carcinoma Cells
by: Silvia Baldari, et al.
Published: (2019-05-01)

Synthesis and Characterization of Heterocyclic Compounds Derived From 4- Hydroxy and 4-Amino Acetophenone
by: Nisreen H. Karam, et al.
Published: (2017-04-01)

Effect of dabrafenib on melanoma cell lines harbouring the BRAF<sup><it>V600D/R</it></sup> mutations
by: Gentilcore Giusy, et al.
Published: (2013-01-01)

Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry
by: Anna Kryshchyshyn, et al.
Published: (2018-06-01)

Association of BRAF<sup>V600E</sup> Mutation with the Aggressive Behavior of Papillary Thyroid Microcarcinoma: A Meta-Analysis of 33 Studies
by: Abdallah S. Attia, et al.
Published: (2022-12-01)

Design, Synthesis, and Biological Evaluation of Novel 3-Cyanopyridone/Pyrazoline Hybrids as Potential Apoptotic Antiproliferative Agents Targeting EGFR/BRAF<sup>V600E</sup> Inhibitory Pathways
by: Lamya H. Al-Wahaibi, et al.
Published: (2023-09-01)

Design, Synthesis, Antiproliferative Actions, and DFT Studies of New Bis–Pyrazoline Derivatives as Dual EGFR/BRAF<sup>V600E</sup> Inhibitors
by: Lamya H. Al-Wahaibi, et al.
Published: (2023-05-01)

Screening study of new thiazolidinone derivatives for anticonvulsant activity
by: M. V. Mishchenko, et al.
Published: (2020-12-01)

Recent Synthetic Developments for Functionalized Azetidinones and Thiazolidinones
by: Patel Firoz Ahemadkhan, et al.
Published: (2020-12-01)

Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAF<sup>V600E</sup> Protein
by: Elisabetta Marini, et al.
Published: (2022-12-01)

4-Thiazolidinones in Heterocyclic Synthesis: Synthesis of Novel Enaminones, Azolopyrimidines and 2-Arylimino-5-arylidene-4-thiazolidinones
by: Hamada Mohamed Ibrahim, et al.
Published: (2012-05-01)

Synthesis of Novel Sulfamethaoxazole 4-Thiazolidinone Hybrids and Their Biological Evaluation
by: Mashooq A. Bhat, et al.
Published: (2020-08-01)

Efficacy of Neoadjuvant Targeted Therapy for Borderline Resectable III B-D or IV Stage BRAF <sup>V600</sup> Mutation-Positive Melanoma
by: Anna M. Czarnecka, et al.
Published: (2021-12-01)

Evaluation of 5-[(<i>Z</i>)-(4-nitrobenzylidene)]-2-(thiazol-2-ylimino)-4-thiazolidinone (Les-6222) as Potential Anticonvulsant Agent
by: Mariia Mishchenko, et al.
Published: (2022-09-01)

CDK4/6 Inhibition Reprograms Mitochondrial Metabolism in BRAF<sup>V600</sup> Melanoma via a p53 Dependent Pathway
by: Nancy T. Santiappillai, et al.
Published: (2021-01-01)

Protein targets of thiazolidinone derivatives in Toxoplasma gondii and insights into their binding to ROP18
by: Diego Molina, et al.
Published: (2018-11-01)

BRAF<sup>V600E</sup> Positivity-Dependent Effect of Age on Papillary Thyroid Cancer Recurrence Risk
by: Joonseon Park, et al.
Published: (2023-11-01)

The Evolutionary Landscape of Treatment for <i>BRAF<sup>V600E</sup></i> Mutant Metastatic Colorectal Cancer
by: Gianluca Mauri, et al.
Published: (2021-01-01)

Synthesis and cytotoxic activity of some new 5-benzylidene-4-thiazolidinones
by: Danniel D. Feitoza, et al.
Published: (2010-07-01)

Drug design: 4-thiazolidinones applications. Part 1. Synthetic routes to the drug-like molecules
by: Roman Lesyk
Published: (2020-03-01)

<sup>V600E</sup>BRAF Inhibition Induces Cytoprotective Autophagy through AMPK in Thyroid Cancer Cells
by: Eva Jiménez-Mora, et al.
Published: (2021-06-01)

Synthesis and anti-leukemic activity of pyrrolidinedione-thiazolidinone hybrids
by: A. Kryshchyshyn, et al.
Published: (2020-04-01)

In vitro evaluation of new 4-thiazolidinones on invasion and growth of Toxoplasma gondii
by: Diego A. Molina, et al.
Published: (2021-08-01)

Association of microRNA Expression and BRAF<sup>V600E</sup> Mutation with Recurrence of Thyroid Cancer
by: Daina Pamedytyte, et al.
Published: (2020-04-01)

Design, Synthesis, Characterization, Biological Activity and ADME Study of New 5-arylidene-4-Thiazolidinones Derivatives Having
by: Duha E. Taha, et al.
Published: (2019-12-01)

Association of MDM2 Overexpression in Ameloblastomas with <i>MDM2</i> Amplification and BRAF<sup>V600E</sup> Expression
by: Konstantinos I. Tosios, et al.
Published: (2024-02-01)

Synthesis and Identification of New <i>N</i>,<i>N</i>-Disubstituted Thiourea, and Thiazolidinone Scaffolds Based on Quinolone Moiety as Urease Inhibitor
by: Yaseen A. M. M. Elshaier, et al.
Published: (2022-10-01)

VE1 Immunohistochemistry Improves the Limit of Genotyping for Detecting <i>BRAF</i><sup>V600E</sup> Mutation in Papillary Thyroid Cancer
by: Sonam Choden, et al.
Published: (2020-03-01)