Thy-1/CD90 a Bidirectional and Lateral Signaling Scaffold
Thy-1/CD90 is a glycoprotein attached to the outer face of the plasma membrane with various functions, which depend on the context of specific physiological or pathological conditions. Many of these reported functions for Thy-1/CD90 arose from studies by our group, which identified the first ligand/...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2019.00132/full |
| _version_ | 1818017312227196928 |
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| author | Lisette Leyton Lisette Leyton Jorge Díaz Jorge Díaz Samuel Martínez Samuel Martínez Esteban Palacios Esteban Palacios Esteban Palacios Leonardo A. Pérez Leonardo A. Pérez Ramón D. Pérez Ramón D. Pérez |
| author_facet | Lisette Leyton Lisette Leyton Jorge Díaz Jorge Díaz Samuel Martínez Samuel Martínez Esteban Palacios Esteban Palacios Esteban Palacios Leonardo A. Pérez Leonardo A. Pérez Ramón D. Pérez Ramón D. Pérez |
| author_sort | Lisette Leyton |
| collection | DOAJ |
| description | Thy-1/CD90 is a glycoprotein attached to the outer face of the plasma membrane with various functions, which depend on the context of specific physiological or pathological conditions. Many of these reported functions for Thy-1/CD90 arose from studies by our group, which identified the first ligand/receptor for Thy-1/CD90 as an integrin. This finding initiated studies directed toward unveiling the molecular mechanisms that operate downstream of Thy-1/CD90 activation, and its possible interaction with proteins in the membrane plane to regulate their function. The association of Thy-1/CD90 with a number of cell surface molecules allows the formation of extra/intracellular multiprotein complexes composed of various ligands and receptors, extracellular matrix proteins, intracellular signaling proteins, and the cytoskeleton. The complexes sense changes that occur inside and outside the cells, with Thy-1/CD90 at the core of this extracellular molecular platform. Molecular platforms are scaffold-containing microdomains where key proteins associate to prominently influence cellular processes and behavior. Each component, by itself, is less effective, but when together with various scaffold proteins to form a platform, the components become more specific and efficient to convey the messages. This review article discusses the experimental evidence that supports the role of Thy-1/CD90 as a membrane-associated platform (ThyMAP). |
| first_indexed | 2024-04-14T07:25:29Z |
| format | Article |
| id | doaj.art-7fec4021edaf487b96abd9eda97684d2 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-14T07:25:29Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-7fec4021edaf487b96abd9eda97684d22022-12-22T02:06:02ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2019-07-01710.3389/fcell.2019.00132472572Thy-1/CD90 a Bidirectional and Lateral Signaling ScaffoldLisette Leyton0Lisette Leyton1Jorge Díaz2Jorge Díaz3Samuel Martínez4Samuel Martínez5Esteban Palacios6Esteban Palacios7Esteban Palacios8Leonardo A. Pérez9Leonardo A. Pérez10Ramón D. Pérez11Ramón D. Pérez12Cellular Communication Laboratory, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago, ChileAdvanced Center for Chronic Diseases (ACCDiS), Center for Exercise, Metabolism and Cancer Studies (CEMC), Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago, ChileCellular Communication Laboratory, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago, ChileAdvanced Center for Chronic Diseases (ACCDiS), Center for Exercise, Metabolism and Cancer Studies (CEMC), Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago, ChileCellular Communication Laboratory, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago, ChileAdvanced Center for Chronic Diseases (ACCDiS), Center for Exercise, Metabolism and Cancer Studies (CEMC), Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago, ChileCellular Communication Laboratory, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago, ChileAdvanced Center for Chronic Diseases (ACCDiS), Center for Exercise, Metabolism and Cancer Studies (CEMC), Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago, ChileLaboratorio de Microbiología Celular, Facultad de Ciencias de la Salud, Universidad Central de Chile, Santiago, ChileCellular Communication Laboratory, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago, ChileAdvanced Center for Chronic Diseases (ACCDiS), Center for Exercise, Metabolism and Cancer Studies (CEMC), Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago, ChileCellular Communication Laboratory, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago, ChileAdvanced Center for Chronic Diseases (ACCDiS), Center for Exercise, Metabolism and Cancer Studies (CEMC), Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago, ChileThy-1/CD90 is a glycoprotein attached to the outer face of the plasma membrane with various functions, which depend on the context of specific physiological or pathological conditions. Many of these reported functions for Thy-1/CD90 arose from studies by our group, which identified the first ligand/receptor for Thy-1/CD90 as an integrin. This finding initiated studies directed toward unveiling the molecular mechanisms that operate downstream of Thy-1/CD90 activation, and its possible interaction with proteins in the membrane plane to regulate their function. The association of Thy-1/CD90 with a number of cell surface molecules allows the formation of extra/intracellular multiprotein complexes composed of various ligands and receptors, extracellular matrix proteins, intracellular signaling proteins, and the cytoskeleton. The complexes sense changes that occur inside and outside the cells, with Thy-1/CD90 at the core of this extracellular molecular platform. Molecular platforms are scaffold-containing microdomains where key proteins associate to prominently influence cellular processes and behavior. Each component, by itself, is less effective, but when together with various scaffold proteins to form a platform, the components become more specific and efficient to convey the messages. This review article discusses the experimental evidence that supports the role of Thy-1/CD90 as a membrane-associated platform (ThyMAP).https://www.frontiersin.org/article/10.3389/fcell.2019.00132/fullGPI-anchorPLATFORMmembrane-associatedintegrinsyndecan 4Thy-1 (CD90) |
| spellingShingle | Lisette Leyton Lisette Leyton Jorge Díaz Jorge Díaz Samuel Martínez Samuel Martínez Esteban Palacios Esteban Palacios Esteban Palacios Leonardo A. Pérez Leonardo A. Pérez Ramón D. Pérez Ramón D. Pérez Thy-1/CD90 a Bidirectional and Lateral Signaling Scaffold Frontiers in Cell and Developmental Biology GPI-anchor PLATFORM membrane-associated integrin syndecan 4 Thy-1 (CD90) |
| title | Thy-1/CD90 a Bidirectional and Lateral Signaling Scaffold |
| title_full | Thy-1/CD90 a Bidirectional and Lateral Signaling Scaffold |
| title_fullStr | Thy-1/CD90 a Bidirectional and Lateral Signaling Scaffold |
| title_full_unstemmed | Thy-1/CD90 a Bidirectional and Lateral Signaling Scaffold |
| title_short | Thy-1/CD90 a Bidirectional and Lateral Signaling Scaffold |
| title_sort | thy 1 cd90 a bidirectional and lateral signaling scaffold |
| topic | GPI-anchor PLATFORM membrane-associated integrin syndecan 4 Thy-1 (CD90) |
| url | https://www.frontiersin.org/article/10.3389/fcell.2019.00132/full |
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