Biphasic Production of Anti-ApoB100 Autoantibodies in Obese Humans and Mice

Biphasic Production of Anti-ApoB100 Autoantibodies in Obese Humans and Mice

Obesity is associated with autoimmunity, a phenomenon considered as harmful. Here we show that obese mice and humans produce IgG-type autoantibodies that specifically recognize apolipoprotein B-100 (ApoB100), its native epitope p210, and the synthetic p210 mimotope pB1. By contrast, antibodies again...

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Bibliographic Details
Main Authors: Moon Kyung Choe, Hyung-Ji Kim, Nan Hee Kim, Bert Binas, Hyo Joon Kim
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceuticals
Subjects:
obese patients
apolipoprotein B-100
IgG-type autoantibody
high-fat diet induced obesity
epitope
mimotope
Online Access:https://www.mdpi.com/1424-8247/14/4/330

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