Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA

Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA

Pif1 family helicases are conserved from bacteria to humans. Here, we report a novel DNA patrolling activity which may underlie Pif1’s diverse functions: a Pif1 monomer preferentially anchors itself to a 3′-tailed DNA junction and periodically reel in the 3′ tail with a step size of one nucleotide,...

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Bibliographic Details
Main Authors: Ruobo Zhou, Jichuan Zhang, Matthew L Bochman, Virginia A Zakian, Taekjip Ha
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-04-01
Series:eLife
Subjects:
Pif1 family helicase
single molecule analysis
G-quadruplexes
R-loop
Online Access:https://elifesciences.org/articles/02190

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