Severity of Subjective Cognitive Complaints and Worries in Older Adults Are Associated With Cerebral Amyloid-β Load
Subjective cognitive decline (SCD) is considered an early risk stage for dementia due to Alzheimer's disease (AD) and the development of pathological brain changes, such as the aggregation of amyloid-beta (amyloid-β) plaques. This study evaluates the association between specific features of SCD...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-08-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.675583/full |
| _version_ | 1818600670864867328 |
|---|---|
| author | Claudia Schwarz Claudia Schwarz Catharina Lange Gloria S. Benson Gloria S. Benson Nora Horn Nora Horn Katharina Wurdack Katharina Wurdack Mathias Lukas Mathias Lukas Ralph Buchert Ralph Buchert Miranka Wirth Agnes Flöel Agnes Flöel |
| author_facet | Claudia Schwarz Claudia Schwarz Catharina Lange Gloria S. Benson Gloria S. Benson Nora Horn Nora Horn Katharina Wurdack Katharina Wurdack Mathias Lukas Mathias Lukas Ralph Buchert Ralph Buchert Miranka Wirth Agnes Flöel Agnes Flöel |
| author_sort | Claudia Schwarz |
| collection | DOAJ |
| description | Subjective cognitive decline (SCD) is considered an early risk stage for dementia due to Alzheimer's disease (AD) and the development of pathological brain changes, such as the aggregation of amyloid-beta (amyloid-β) plaques. This study evaluates the association between specific features of SCD and cerebral amyloid-β load measured by positron emission tomography (PET) with 18F-florbetaben in 40 cognitively normal older individuals. Global amyloid-β, as well as regional amyloid-β load for the frontal, temporal, parietal, and cingulate cortex, was quantified. Specific features of SCD, such as subjective cognitive complaints and worry, were assessed using the 39-item Everyday Cognition Scales and the 16-item Penn State Worry Questionnaire. Spearman's rank partial correlation analyses, adjusted for age and apolipoprotein E ε4 status, were conducted to test the associations between specific features of SCD and cerebral amyloid-β load. The severity of subjective cognitive complaints in everyday memory and organization was positively correlated with amyloid-β load in the frontal cortex. In addition, the severity of subjective cognitive complaints in everyday planning was positively correlated with amyloid-β load in the parietal cortex. Higher levels of worry were associated with higher amyloid-β load in the frontal cortex. After correction of the PET data for partial volume effects, these associations were reduced to trend level. In conclusion, the severity of subjective cognitive complaints and the level of trait worry were positively associated with cortical amyloid-β burden, particularly in the frontal and parietal cortex. Further studies are required to elucidate the direction of these associations in order to develop strategies to prevent amyloid deposition and cognitive decline. |
| first_indexed | 2024-12-16T12:39:11Z |
| format | Article |
| id | doaj.art-7fed440c118e434cbdef2e21b7ed2e4e |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-16T12:39:11Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-7fed440c118e434cbdef2e21b7ed2e4e2022-12-21T22:31:28ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-08-011310.3389/fnagi.2021.675583675583Severity of Subjective Cognitive Complaints and Worries in Older Adults Are Associated With Cerebral Amyloid-β LoadClaudia Schwarz0Claudia Schwarz1Catharina Lange2Gloria S. Benson3Gloria S. Benson4Nora Horn5Nora Horn6Katharina Wurdack7Katharina Wurdack8Mathias Lukas9Mathias Lukas10Ralph Buchert11Ralph Buchert12Miranka Wirth13Agnes Flöel14Agnes Flöel15Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyNeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyDepartment of Nuclear Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyDepartment of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyNeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyDepartment of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyNeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyDepartment of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyNeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyDepartment of Nuclear Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanySiemens Healthcare GmbH, Berlin, GermanyDepartment of Nuclear Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyDepartment for Diagnostic and Interventional Radiology and Nuclear Medicine, University Hospital Hamburg-Eppendorf, Hamburg, GermanyGerman Center for Neurodegenerative Diseases (DZNE) Site: Dresden, Dresden, GermanyDepartment of Neurology, University Medicine Greifswald, Greifswald, GermanyGerman Center for Neurodegenerative Diseases (DZNE) Site: Greifswald, Greifswald, GermanySubjective cognitive decline (SCD) is considered an early risk stage for dementia due to Alzheimer's disease (AD) and the development of pathological brain changes, such as the aggregation of amyloid-beta (amyloid-β) plaques. This study evaluates the association between specific features of SCD and cerebral amyloid-β load measured by positron emission tomography (PET) with 18F-florbetaben in 40 cognitively normal older individuals. Global amyloid-β, as well as regional amyloid-β load for the frontal, temporal, parietal, and cingulate cortex, was quantified. Specific features of SCD, such as subjective cognitive complaints and worry, were assessed using the 39-item Everyday Cognition Scales and the 16-item Penn State Worry Questionnaire. Spearman's rank partial correlation analyses, adjusted for age and apolipoprotein E ε4 status, were conducted to test the associations between specific features of SCD and cerebral amyloid-β load. The severity of subjective cognitive complaints in everyday memory and organization was positively correlated with amyloid-β load in the frontal cortex. In addition, the severity of subjective cognitive complaints in everyday planning was positively correlated with amyloid-β load in the parietal cortex. Higher levels of worry were associated with higher amyloid-β load in the frontal cortex. After correction of the PET data for partial volume effects, these associations were reduced to trend level. In conclusion, the severity of subjective cognitive complaints and the level of trait worry were positively associated with cortical amyloid-β burden, particularly in the frontal and parietal cortex. Further studies are required to elucidate the direction of these associations in order to develop strategies to prevent amyloid deposition and cognitive decline.https://www.frontiersin.org/articles/10.3389/fnagi.2021.675583/fullsubjective cognitive declinepreclinical Alzheimer's disease18F-florbetaben PETamyloidbiomarkerscognitively normal |
| spellingShingle | Claudia Schwarz Claudia Schwarz Catharina Lange Gloria S. Benson Gloria S. Benson Nora Horn Nora Horn Katharina Wurdack Katharina Wurdack Mathias Lukas Mathias Lukas Ralph Buchert Ralph Buchert Miranka Wirth Agnes Flöel Agnes Flöel Severity of Subjective Cognitive Complaints and Worries in Older Adults Are Associated With Cerebral Amyloid-β Load Frontiers in Aging Neuroscience subjective cognitive decline preclinical Alzheimer's disease 18F-florbetaben PET amyloid biomarkers cognitively normal |
| title | Severity of Subjective Cognitive Complaints and Worries in Older Adults Are Associated With Cerebral Amyloid-β Load |
| title_full | Severity of Subjective Cognitive Complaints and Worries in Older Adults Are Associated With Cerebral Amyloid-β Load |
| title_fullStr | Severity of Subjective Cognitive Complaints and Worries in Older Adults Are Associated With Cerebral Amyloid-β Load |
| title_full_unstemmed | Severity of Subjective Cognitive Complaints and Worries in Older Adults Are Associated With Cerebral Amyloid-β Load |
| title_short | Severity of Subjective Cognitive Complaints and Worries in Older Adults Are Associated With Cerebral Amyloid-β Load |
| title_sort | severity of subjective cognitive complaints and worries in older adults are associated with cerebral amyloid β load |
| topic | subjective cognitive decline preclinical Alzheimer's disease 18F-florbetaben PET amyloid biomarkers cognitively normal |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.675583/full |
| work_keys_str_mv | AT claudiaschwarz severityofsubjectivecognitivecomplaintsandworriesinolderadultsareassociatedwithcerebralamyloidbload AT claudiaschwarz severityofsubjectivecognitivecomplaintsandworriesinolderadultsareassociatedwithcerebralamyloidbload AT catharinalange severityofsubjectivecognitivecomplaintsandworriesinolderadultsareassociatedwithcerebralamyloidbload AT gloriasbenson severityofsubjectivecognitivecomplaintsandworriesinolderadultsareassociatedwithcerebralamyloidbload AT gloriasbenson severityofsubjectivecognitivecomplaintsandworriesinolderadultsareassociatedwithcerebralamyloidbload AT norahorn severityofsubjectivecognitivecomplaintsandworriesinolderadultsareassociatedwithcerebralamyloidbload AT norahorn severityofsubjectivecognitivecomplaintsandworriesinolderadultsareassociatedwithcerebralamyloidbload AT katharinawurdack severityofsubjectivecognitivecomplaintsandworriesinolderadultsareassociatedwithcerebralamyloidbload AT katharinawurdack severityofsubjectivecognitivecomplaintsandworriesinolderadultsareassociatedwithcerebralamyloidbload AT mathiaslukas severityofsubjectivecognitivecomplaintsandworriesinolderadultsareassociatedwithcerebralamyloidbload AT mathiaslukas severityofsubjectivecognitivecomplaintsandworriesinolderadultsareassociatedwithcerebralamyloidbload AT ralphbuchert severityofsubjectivecognitivecomplaintsandworriesinolderadultsareassociatedwithcerebralamyloidbload AT ralphbuchert severityofsubjectivecognitivecomplaintsandworriesinolderadultsareassociatedwithcerebralamyloidbload AT mirankawirth severityofsubjectivecognitivecomplaintsandworriesinolderadultsareassociatedwithcerebralamyloidbload AT agnesfloel severityofsubjectivecognitivecomplaintsandworriesinolderadultsareassociatedwithcerebralamyloidbload AT agnesfloel severityofsubjectivecognitivecomplaintsandworriesinolderadultsareassociatedwithcerebralamyloidbload |