Systemic lupus erythematosus and immunodeficiency
Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease that develops in genetically susceptible individuals in response to environmental factors. SLE and primary immunodeficiency disease (PID) share some clinical manifestations in that certain PIDs present with autoimmune phe...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Immunological Medicine |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/25785826.2019.1628466 |
| _version_ | 1828469253296095232 |
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| author | Tetsuji Sawada Daiki Fujimori Yusuke Yamamoto |
| author_facet | Tetsuji Sawada Daiki Fujimori Yusuke Yamamoto |
| author_sort | Tetsuji Sawada |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease that develops in genetically susceptible individuals in response to environmental factors. SLE and primary immunodeficiency disease (PID) share some clinical manifestations in that certain PIDs present with autoimmune phenomena. Patients with SLE become susceptible to infection via three pathways. First, SLE and PID share some genetic factors, such as complement and mannose-binding lectin genes, which predispose patients to infection. Second, patients with SLE have an inherently high risk of infection because of their intrinsic immunological abnormalities induced by SLE. Third, patients with SLE receiving immunosuppressive treatment are at high risk of infection. Further studies delineating the abnormalities related to both autoimmunity and immunodeficiency would be warranted to identify a new potential drug target for SLE. |
| first_indexed | 2024-12-11T04:36:29Z |
| format | Article |
| id | doaj.art-7fed704cf7b248af8f629a7ea7bd82c0 |
| institution | Directory Open Access Journal |
| issn | 2578-5826 |
| language | English |
| last_indexed | 2024-12-11T04:36:29Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Immunological Medicine |
| spelling | doaj.art-7fed704cf7b248af8f629a7ea7bd82c02022-12-22T01:20:43ZengTaylor & Francis GroupImmunological Medicine2578-58262019-01-014211910.1080/25785826.2019.16284661628466Systemic lupus erythematosus and immunodeficiencyTetsuji Sawada0Daiki Fujimori1Yusuke Yamamoto2Tokyo Medical University HospitalTokyo Medical University HospitalTokyo Medical University HospitalSystemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease that develops in genetically susceptible individuals in response to environmental factors. SLE and primary immunodeficiency disease (PID) share some clinical manifestations in that certain PIDs present with autoimmune phenomena. Patients with SLE become susceptible to infection via three pathways. First, SLE and PID share some genetic factors, such as complement and mannose-binding lectin genes, which predispose patients to infection. Second, patients with SLE have an inherently high risk of infection because of their intrinsic immunological abnormalities induced by SLE. Third, patients with SLE receiving immunosuppressive treatment are at high risk of infection. Further studies delineating the abnormalities related to both autoimmunity and immunodeficiency would be warranted to identify a new potential drug target for SLE.http://dx.doi.org/10.1080/25785826.2019.1628466systemic lupus erythematosusimmunodeficiencyinfection |
| spellingShingle | Tetsuji Sawada Daiki Fujimori Yusuke Yamamoto Systemic lupus erythematosus and immunodeficiency Immunological Medicine systemic lupus erythematosus immunodeficiency infection |
| title | Systemic lupus erythematosus and immunodeficiency |
| title_full | Systemic lupus erythematosus and immunodeficiency |
| title_fullStr | Systemic lupus erythematosus and immunodeficiency |
| title_full_unstemmed | Systemic lupus erythematosus and immunodeficiency |
| title_short | Systemic lupus erythematosus and immunodeficiency |
| title_sort | systemic lupus erythematosus and immunodeficiency |
| topic | systemic lupus erythematosus immunodeficiency infection |
| url | http://dx.doi.org/10.1080/25785826.2019.1628466 |
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