he impact of drug-loading factors on the solid-state form of ritonavir-mesoporous silica systems
Among the formulation techniques used to enhance the solubility and dissolution rate of poorly, aqueous-soluble drugs, mesoporous silica drug delivery systems have shown promise. A range of processes are employed to load drugs onto silica and solvent-based approaches are widely employed. This study...
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| Format: | Article |
| Language: | English |
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University of Huddersfield Press
2022-11-01
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| Series: | British Journal of Pharmacy |
| Subjects: | |
| Online Access: | https://www.bjpharm.org.uk/article/id/1150/ |
| _version_ | 1827945994015211520 |
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| author | Tanweer Al-Dagamin Joseph P O'Shea Abina Crean |
| author_facet | Tanweer Al-Dagamin Joseph P O'Shea Abina Crean |
| author_sort | Tanweer Al-Dagamin |
| collection | DOAJ |
| description | Among the formulation techniques used to enhance the solubility and dissolution rate of poorly, aqueous-soluble drugs, mesoporous silica drug delivery systems have shown promise. A range of processes are employed to load drugs onto silica and solvent-based approaches are widely employed. This study aims to understand the influence of drug concentration insolvent and drug-silica ratio on drug solid-state form and amorphization within silica. Ritonavir which belongs to BCS Class II was used as a model drug. Ritonavir was loaded into Syloid®244FP using a solvent evaporation method. Ritonavir loading percentage was calculated based on the assumption that the entire specific surface area of silica is exposed and available for drug adsorption. Ethanol solutions with 3 different ritonavir concentrations; 70%, 32% and 20% saturated solubility at 25°C were employed. Ritonavir was loaded into silica at 1:1, 1:2and 1:3 ritonavir:silica ratios. All systems included ritonavir loaded beyond monolayer surface coverage. Ritonavir- Syloid®244 FP formulations were characterised using DSC, PXRD, FT-IR, and TGA. The results showed that all ritonavir-Syloid®244 FP systems prepared contained ritonavir in a non-crystalline state. |
| first_indexed | 2024-03-13T10:52:24Z |
| format | Article |
| id | doaj.art-7fedea3c6e2d41a7afdae45b37fa4f32 |
| institution | Directory Open Access Journal |
| issn | 2058-8356 |
| language | English |
| last_indexed | 2024-03-13T10:52:24Z |
| publishDate | 2022-11-01 |
| publisher | University of Huddersfield Press |
| record_format | Article |
| series | British Journal of Pharmacy |
| spelling | doaj.art-7fedea3c6e2d41a7afdae45b37fa4f322023-05-17T10:23:20ZengUniversity of Huddersfield PressBritish Journal of Pharmacy2058-83562022-11-017210.5920/bjpharm.1150he impact of drug-loading factors on the solid-state form of ritonavir-mesoporous silica systemsTanweer Al-Dagamin0Joseph P O'Shea 1Abina Crean2University College CorkUniversity College CorkUniversity College CorkAmong the formulation techniques used to enhance the solubility and dissolution rate of poorly, aqueous-soluble drugs, mesoporous silica drug delivery systems have shown promise. A range of processes are employed to load drugs onto silica and solvent-based approaches are widely employed. This study aims to understand the influence of drug concentration insolvent and drug-silica ratio on drug solid-state form and amorphization within silica. Ritonavir which belongs to BCS Class II was used as a model drug. Ritonavir was loaded into Syloid®244FP using a solvent evaporation method. Ritonavir loading percentage was calculated based on the assumption that the entire specific surface area of silica is exposed and available for drug adsorption. Ethanol solutions with 3 different ritonavir concentrations; 70%, 32% and 20% saturated solubility at 25°C were employed. Ritonavir was loaded into silica at 1:1, 1:2and 1:3 ritonavir:silica ratios. All systems included ritonavir loaded beyond monolayer surface coverage. Ritonavir- Syloid®244 FP formulations were characterised using DSC, PXRD, FT-IR, and TGA. The results showed that all ritonavir-Syloid®244 FP systems prepared contained ritonavir in a non-crystalline state.https://www.bjpharm.org.uk/article/id/1150/mesoporous silicaritonavirsolid-state |
| spellingShingle | Tanweer Al-Dagamin Joseph P O'Shea Abina Crean he impact of drug-loading factors on the solid-state form of ritonavir-mesoporous silica systems British Journal of Pharmacy mesoporous silica ritonavir solid-state |
| title | he impact of drug-loading factors on the solid-state form of ritonavir-mesoporous silica systems |
| title_full | he impact of drug-loading factors on the solid-state form of ritonavir-mesoporous silica systems |
| title_fullStr | he impact of drug-loading factors on the solid-state form of ritonavir-mesoporous silica systems |
| title_full_unstemmed | he impact of drug-loading factors on the solid-state form of ritonavir-mesoporous silica systems |
| title_short | he impact of drug-loading factors on the solid-state form of ritonavir-mesoporous silica systems |
| title_sort | he impact of drug loading factors on the solid state form of ritonavir mesoporous silica systems |
| topic | mesoporous silica ritonavir solid-state |
| url | https://www.bjpharm.org.uk/article/id/1150/ |
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