Prevalence and prognostic role of L wave and selected clinical and echocardiographic variables in dogs with atrial fibrillation
Abstract Background Information regarding the frequency of L waves and their prognostic relevance in dogs with secondary atrial fibrillation (AF) is limited. Hypothesis/Objectives To determine whether L waves occur and ascertain their prognostic role, as well as the role of other clinical and echoca...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.16584 |
| _version_ | 1797938056524726272 |
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| author | Giovanni Romito Stefana Darida Carlotta Valente Helen Poser Barbara Contiero Mario Cipone Carlo Guglielmini |
| author_facet | Giovanni Romito Stefana Darida Carlotta Valente Helen Poser Barbara Contiero Mario Cipone Carlo Guglielmini |
| author_sort | Giovanni Romito |
| collection | DOAJ |
| description | Abstract Background Information regarding the frequency of L waves and their prognostic relevance in dogs with secondary atrial fibrillation (AF) is limited. Hypothesis/Objectives To determine whether L waves occur and ascertain their prognostic role, as well as the role of other clinical and echocardiographic variables in dogs with AF. Animals Fifty‐five dogs with AF associated with myxomatous mitral valve disease or dilated cardiomyopathy. Methods Retrospective, multicenter observational study. In addition to L waves analysis, other clinical and echocardiographic variables, including type of antiarrhythmic treatment, were evaluated. A survival analysis was performed to test for predictors of cardiac death and all‐cause mortality using Cox proportional hazards regression models. Results L waves were evident in 33/55 dogs (60%, 95% confidence interval [CI] = 47%‐72%) but their presence did not influence outcome. Increased left ventricular end‐systolic diameter normalized for body weight (LVSDn) was a significant predictor of both cardiac death (hazard ratio [HR] = 4.41, 95% CI = 1.18‐16.54; P = .03) and all‐cause mortality (HR = 9.39, 95% CI = 2.49‐35.32; P < .001). Heart rate assessed during echocardiography (Echo‐HR) represented an additional significant predictor of cardiac death (HR = 1.01, 95% CI = 1.00‐1.01; P = .04) and all‐cause mortality (HR = 1.01, 95% CI = 1.00‐1.01; P = .04). Conclusions and Clinical Importance L waves occurred frequently in dogs with AF, but held no prognostic relevance. Conversely, LVSDn and Echo‐HR represented independent predictors of negative outcome in these animals. |
| first_indexed | 2024-04-10T18:53:45Z |
| format | Article |
| id | doaj.art-7fee7b7db2754941ab1c0101e6634ce2 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-04-10T18:53:45Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-7fee7b7db2754941ab1c0101e6634ce22023-02-01T04:49:51ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762023-01-01371475710.1111/jvim.16584Prevalence and prognostic role of L wave and selected clinical and echocardiographic variables in dogs with atrial fibrillationGiovanni Romito0Stefana Darida1Carlotta Valente2Helen Poser3Barbara Contiero4Mario Cipone5Carlo Guglielmini6Department of Veterinary Medical Sciences Alma Mater Studiorum—University of Bologna (Romito, Darida, Cipone) Bologna ItalyDepartment of Veterinary Medical Sciences Alma Mater Studiorum—University of Bologna (Romito, Darida, Cipone) Bologna ItalyDepartment of Animal Medicine Production and Health (Valente, Poser, Contiero, Guglielmini), University of Padova Padua ItalyDepartment of Animal Medicine Production and Health (Valente, Poser, Contiero, Guglielmini), University of Padova Padua ItalyDepartment of Animal Medicine Production and Health (Valente, Poser, Contiero, Guglielmini), University of Padova Padua ItalyDepartment of Veterinary Medical Sciences Alma Mater Studiorum—University of Bologna (Romito, Darida, Cipone) Bologna ItalyDepartment of Animal Medicine Production and Health (Valente, Poser, Contiero, Guglielmini), University of Padova Padua ItalyAbstract Background Information regarding the frequency of L waves and their prognostic relevance in dogs with secondary atrial fibrillation (AF) is limited. Hypothesis/Objectives To determine whether L waves occur and ascertain their prognostic role, as well as the role of other clinical and echocardiographic variables in dogs with AF. Animals Fifty‐five dogs with AF associated with myxomatous mitral valve disease or dilated cardiomyopathy. Methods Retrospective, multicenter observational study. In addition to L waves analysis, other clinical and echocardiographic variables, including type of antiarrhythmic treatment, were evaluated. A survival analysis was performed to test for predictors of cardiac death and all‐cause mortality using Cox proportional hazards regression models. Results L waves were evident in 33/55 dogs (60%, 95% confidence interval [CI] = 47%‐72%) but their presence did not influence outcome. Increased left ventricular end‐systolic diameter normalized for body weight (LVSDn) was a significant predictor of both cardiac death (hazard ratio [HR] = 4.41, 95% CI = 1.18‐16.54; P = .03) and all‐cause mortality (HR = 9.39, 95% CI = 2.49‐35.32; P < .001). Heart rate assessed during echocardiography (Echo‐HR) represented an additional significant predictor of cardiac death (HR = 1.01, 95% CI = 1.00‐1.01; P = .04) and all‐cause mortality (HR = 1.01, 95% CI = 1.00‐1.01; P = .04). Conclusions and Clinical Importance L waves occurred frequently in dogs with AF, but held no prognostic relevance. Conversely, LVSDn and Echo‐HR represented independent predictors of negative outcome in these animals.https://doi.org/10.1111/jvim.16584caninecardiac arrhythmiasdilated cardiomyopathymyxomatous mitral valve diseasesurvival analysistransthoracic echocardiography |
| spellingShingle | Giovanni Romito Stefana Darida Carlotta Valente Helen Poser Barbara Contiero Mario Cipone Carlo Guglielmini Prevalence and prognostic role of L wave and selected clinical and echocardiographic variables in dogs with atrial fibrillation Journal of Veterinary Internal Medicine canine cardiac arrhythmias dilated cardiomyopathy myxomatous mitral valve disease survival analysis transthoracic echocardiography |
| title | Prevalence and prognostic role of L wave and selected clinical and echocardiographic variables in dogs with atrial fibrillation |
| title_full | Prevalence and prognostic role of L wave and selected clinical and echocardiographic variables in dogs with atrial fibrillation |
| title_fullStr | Prevalence and prognostic role of L wave and selected clinical and echocardiographic variables in dogs with atrial fibrillation |
| title_full_unstemmed | Prevalence and prognostic role of L wave and selected clinical and echocardiographic variables in dogs with atrial fibrillation |
| title_short | Prevalence and prognostic role of L wave and selected clinical and echocardiographic variables in dogs with atrial fibrillation |
| title_sort | prevalence and prognostic role of l wave and selected clinical and echocardiographic variables in dogs with atrial fibrillation |
| topic | canine cardiac arrhythmias dilated cardiomyopathy myxomatous mitral valve disease survival analysis transthoracic echocardiography |
| url | https://doi.org/10.1111/jvim.16584 |
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