Association Between Serum Matrix Metalloproteinase-2 Levels and Mean Doppler Pulsatility Index of Uterine Arteries in Patients with Preeclampsia
Background: Мatrix metalloproteinase-2 (MMP-2) is an enzye from the gelatinases family involved mainly in collagen degradation. It is also known as a key regulator of normal vascular remodelling during a healthy pregnancy. Failure of regulation of MMP-2 has been associated with abnormal vasodilation...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2022-10-01
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| Series: | Acta Medica Bulgarica |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/amb-2022-0025 |
| _version_ | 1797778317370195968 |
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| author | Nikolov A. Popovski N. Hristova I. |
| author_facet | Nikolov A. Popovski N. Hristova I. |
| author_sort | Nikolov A. |
| collection | DOAJ |
| description | Background: Мatrix metalloproteinase-2 (MMP-2) is an enzye from the gelatinases family involved mainly in collagen degradation. It is also known as a key regulator of normal vascular remodelling during a healthy pregnancy. Failure of regulation of MMP-2 has been associated with abnormal vasodilation, placentation, uterine expansion and development of preeclampsia (PE). Aims: (1) determine serum MMP-2 levels in women with PE and healthy pregnancy, (2) evaluate mean uterine arteries Doppler pulsatility index (UtA PI) and (3) investigate the a possible association between these parameters. |
| first_indexed | 2024-03-12T23:16:29Z |
| format | Article |
| id | doaj.art-7fef69e01bd4406f9f3102eab2984ec1 |
| institution | Directory Open Access Journal |
| issn | 2719-5384 |
| language | English |
| last_indexed | 2024-03-12T23:16:29Z |
| publishDate | 2022-10-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Medica Bulgarica |
| spelling | doaj.art-7fef69e01bd4406f9f3102eab2984ec12023-07-17T05:26:08ZengSciendoActa Medica Bulgarica2719-53842022-10-01493192410.2478/amb-2022-0025Association Between Serum Matrix Metalloproteinase-2 Levels and Mean Doppler Pulsatility Index of Uterine Arteries in Patients with PreeclampsiaNikolov A.0Popovski N.1Hristova I.2Division of Medicine, Cardiovascular Research Working Group, Institute for Scientific Research, Medical University – Pleven, BulgariaClinic of Obstetrics and Gynaecology, University Hospital Pleven, Department of Obstetrics and Gynaecology, Medical University – Pleven, BulgariaDepartment of Midwifery, Faculty of Health Care, Medical University – Pleven, BulgariaBackground: Мatrix metalloproteinase-2 (MMP-2) is an enzye from the gelatinases family involved mainly in collagen degradation. It is also known as a key regulator of normal vascular remodelling during a healthy pregnancy. Failure of regulation of MMP-2 has been associated with abnormal vasodilation, placentation, uterine expansion and development of preeclampsia (PE). Aims: (1) determine serum MMP-2 levels in women with PE and healthy pregnancy, (2) evaluate mean uterine arteries Doppler pulsatility index (UtA PI) and (3) investigate the a possible association between these parameters.https://doi.org/10.2478/amb-2022-0025matrix metalloproteinase-2preeclampsiauterine doppler pulsatility index |
| spellingShingle | Nikolov A. Popovski N. Hristova I. Association Between Serum Matrix Metalloproteinase-2 Levels and Mean Doppler Pulsatility Index of Uterine Arteries in Patients with Preeclampsia Acta Medica Bulgarica matrix metalloproteinase-2 preeclampsia uterine doppler pulsatility index |
| title | Association Between Serum Matrix Metalloproteinase-2 Levels and Mean Doppler Pulsatility Index of Uterine Arteries in Patients with Preeclampsia |
| title_full | Association Between Serum Matrix Metalloproteinase-2 Levels and Mean Doppler Pulsatility Index of Uterine Arteries in Patients with Preeclampsia |
| title_fullStr | Association Between Serum Matrix Metalloproteinase-2 Levels and Mean Doppler Pulsatility Index of Uterine Arteries in Patients with Preeclampsia |
| title_full_unstemmed | Association Between Serum Matrix Metalloproteinase-2 Levels and Mean Doppler Pulsatility Index of Uterine Arteries in Patients with Preeclampsia |
| title_short | Association Between Serum Matrix Metalloproteinase-2 Levels and Mean Doppler Pulsatility Index of Uterine Arteries in Patients with Preeclampsia |
| title_sort | association between serum matrix metalloproteinase 2 levels and mean doppler pulsatility index of uterine arteries in patients with preeclampsia |
| topic | matrix metalloproteinase-2 preeclampsia uterine doppler pulsatility index |
| url | https://doi.org/10.2478/amb-2022-0025 |
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