Survival after repeated surgery for lung cancer with idiopathic pulmonary fibrosis: a retrospective study
Abstract Background Patients with idiopathic pulmonary fibrosis (IPF) have a high risk of developing lung cancer, but few studies have investigated the long-term outcomes of repeated surgery in such patients. The purpose of this study was to evaluate the surgical outcomes of repeated lung cancer sur...
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| Format: | Article |
| Language: | English |
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BMC
2018-08-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s12890-018-0703-8 |
| _version_ | 1818131729544642560 |
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| author | Seijiro Sato Yuki Shimizu Tatsuya Goto Akihiko Kitahara Terumoto Koike Hiroyuki Ishikawa Takehiro Watanabe Masanori Tsuchida |
| author_facet | Seijiro Sato Yuki Shimizu Tatsuya Goto Akihiko Kitahara Terumoto Koike Hiroyuki Ishikawa Takehiro Watanabe Masanori Tsuchida |
| author_sort | Seijiro Sato |
| collection | DOAJ |
| description | Abstract Background Patients with idiopathic pulmonary fibrosis (IPF) have a high risk of developing lung cancer, but few studies have investigated the long-term outcomes of repeated surgery in such patients. The purpose of this study was to evaluate the surgical outcomes of repeated lung cancer surgery in patients with IPF. Methods From January 2001 to December 2015, 108 lung cancer patients with IPF underwent pulmonary resection at two institutions; 13 of these patients underwent repeated surgery for lung cancer, and their data were reviewed. Results The initial procedures of the 13 patients were lobectomy in 8, segmentectomy in 2, and wedge resection in 3. The subsequent procedures were wedge resection in 10 and segmentectomy in 3. The clinical stage of the second tumor was stage IA in 12 and stage IB in 1. Postoperatively, 3 patients (23.1%) developed acute exacerbation (AE) of IPF and died. The rate of decrease in percent vital capacity was significantly higher in patients with AE than in those without AE (p = 0.011). The 3-year overall survival rate was 34.6%. The causes of death were cancer-related in 7, AE of IPF in 3, and metachronous lung cancer in 1. Conclusions Despite limited resection, a high incidence of AE was identified. The early and long-term outcomes of repeated surgery in lung cancer patients with IPF were poor because of the high risk of AE of IPF and lung cancer recurrence. Long-term intensive surveillance will be required to determine whether surgical intervention is justified in patients with multiple primary lung cancers and IPF. |
| first_indexed | 2024-12-11T08:25:34Z |
| format | Article |
| id | doaj.art-7fef92b5867649938fcc80af22f04446 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-11T08:25:34Z |
| publishDate | 2018-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-7fef92b5867649938fcc80af22f044462022-12-22T01:14:34ZengBMCBMC Pulmonary Medicine1471-24662018-08-011811910.1186/s12890-018-0703-8Survival after repeated surgery for lung cancer with idiopathic pulmonary fibrosis: a retrospective studySeijiro Sato0Yuki Shimizu1Tatsuya Goto2Akihiko Kitahara3Terumoto Koike4Hiroyuki Ishikawa5Takehiro Watanabe6Masanori Tsuchida7Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental SciencesDivision of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental SciencesDivision of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental SciencesDivision of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental SciencesDivision of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental SciencesDepartment of Radiology and Radiation Oncology, Niigata University Graduate School of Medical and Dental SciencesDepartment of Thoracic Surgery, National Hospital Organization Nishi-Niigata Chuo National HospitalDivision of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental SciencesAbstract Background Patients with idiopathic pulmonary fibrosis (IPF) have a high risk of developing lung cancer, but few studies have investigated the long-term outcomes of repeated surgery in such patients. The purpose of this study was to evaluate the surgical outcomes of repeated lung cancer surgery in patients with IPF. Methods From January 2001 to December 2015, 108 lung cancer patients with IPF underwent pulmonary resection at two institutions; 13 of these patients underwent repeated surgery for lung cancer, and their data were reviewed. Results The initial procedures of the 13 patients were lobectomy in 8, segmentectomy in 2, and wedge resection in 3. The subsequent procedures were wedge resection in 10 and segmentectomy in 3. The clinical stage of the second tumor was stage IA in 12 and stage IB in 1. Postoperatively, 3 patients (23.1%) developed acute exacerbation (AE) of IPF and died. The rate of decrease in percent vital capacity was significantly higher in patients with AE than in those without AE (p = 0.011). The 3-year overall survival rate was 34.6%. The causes of death were cancer-related in 7, AE of IPF in 3, and metachronous lung cancer in 1. Conclusions Despite limited resection, a high incidence of AE was identified. The early and long-term outcomes of repeated surgery in lung cancer patients with IPF were poor because of the high risk of AE of IPF and lung cancer recurrence. Long-term intensive surveillance will be required to determine whether surgical intervention is justified in patients with multiple primary lung cancers and IPF.http://link.springer.com/article/10.1186/s12890-018-0703-8Lung cancerIdiopathic pulmonary fibrosisRepeated surgeryAcute exacerbationPercent vital capacity |
| spellingShingle | Seijiro Sato Yuki Shimizu Tatsuya Goto Akihiko Kitahara Terumoto Koike Hiroyuki Ishikawa Takehiro Watanabe Masanori Tsuchida Survival after repeated surgery for lung cancer with idiopathic pulmonary fibrosis: a retrospective study BMC Pulmonary Medicine Lung cancer Idiopathic pulmonary fibrosis Repeated surgery Acute exacerbation Percent vital capacity |
| title | Survival after repeated surgery for lung cancer with idiopathic pulmonary fibrosis: a retrospective study |
| title_full | Survival after repeated surgery for lung cancer with idiopathic pulmonary fibrosis: a retrospective study |
| title_fullStr | Survival after repeated surgery for lung cancer with idiopathic pulmonary fibrosis: a retrospective study |
| title_full_unstemmed | Survival after repeated surgery for lung cancer with idiopathic pulmonary fibrosis: a retrospective study |
| title_short | Survival after repeated surgery for lung cancer with idiopathic pulmonary fibrosis: a retrospective study |
| title_sort | survival after repeated surgery for lung cancer with idiopathic pulmonary fibrosis a retrospective study |
| topic | Lung cancer Idiopathic pulmonary fibrosis Repeated surgery Acute exacerbation Percent vital capacity |
| url | http://link.springer.com/article/10.1186/s12890-018-0703-8 |
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