The role of klotho in chronic kidney disease
Abstract Chronic kidney disease (CKD) is an inherently systemic disease that refers to a long-term loss of kidney function. The progression of CKD has repercussions for other organs, leading to many kinds of extrarenal complications. Intensive studies are now being undertaken to reveal the risk fact...
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| Format: | Article |
| Language: | English |
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BMC
2018-10-01
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| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12882-018-1094-z |
| _version_ | 1798043063497523200 |
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| author | Di Zou Wen Wu Yan He Sichao Ma Ji Gao |
| author_facet | Di Zou Wen Wu Yan He Sichao Ma Ji Gao |
| author_sort | Di Zou |
| collection | DOAJ |
| description | Abstract Chronic kidney disease (CKD) is an inherently systemic disease that refers to a long-term loss of kidney function. The progression of CKD has repercussions for other organs, leading to many kinds of extrarenal complications. Intensive studies are now being undertaken to reveal the risk factors and pathophysiological mechanism of this disease. During the past 20 years, increasing evidence from clinical and basic studies has indicated that klotho, which was initially known as an anti-aging gene and is mainly expressed in the kidney, is significantly correlated with the development and progression of CKD and its complications. Here, we discuss in detail the role and pathophysiological implications of klotho in ion disorders, the inflammation response, vascular calcification, mineral bone disorders, and renal fibrosis in CKD. Based on the pathogenic mechanism of klotho deficiency and klotho decline in urine early in CKD stage 2 and even earlier in CKD stage 1, it is not difficult to understand that soluble klotho can serve as an early and sensitive marker of CKD. Moreover, the prevention of klotho decline by several mechanisms can attenuate renal injuries, retard CKD progression, ameliorate extrarenal complications, and improve renal function. In this review, we focus on the functions and pathophysiological implications of klotho in CKD and its extrarenal complications as well as its potential applications as a diagnostic and/or prognostic biomarker for CKD and as a novel treatment strategy to improve and decrease the burden of comorbidity in CKD. |
| first_indexed | 2024-04-11T22:44:23Z |
| format | Article |
| id | doaj.art-7fefa085f6614ceba28a14099e9c2cce |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-04-11T22:44:23Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-7fefa085f6614ceba28a14099e9c2cce2022-12-22T03:58:49ZengBMCBMC Nephrology1471-23692018-10-0119111210.1186/s12882-018-1094-zThe role of klotho in chronic kidney diseaseDi Zou0Wen Wu1Yan He2Sichao Ma3Ji Gao4Department of Nephrology, The First Affiliated Hospital to Changchun University of Chinese MedicineDepartment of Medical Ultrasonics, PLA Army General HospitalDepartment of Nephrology, The First Affiliated Hospital to Changchun University of Chinese MedicineDepartment of Nephrology, The First Affiliated Hospital to Changchun University of Chinese MedicineDepartment of Urology, China-Japan Union Hospital, Jilin UniversityAbstract Chronic kidney disease (CKD) is an inherently systemic disease that refers to a long-term loss of kidney function. The progression of CKD has repercussions for other organs, leading to many kinds of extrarenal complications. Intensive studies are now being undertaken to reveal the risk factors and pathophysiological mechanism of this disease. During the past 20 years, increasing evidence from clinical and basic studies has indicated that klotho, which was initially known as an anti-aging gene and is mainly expressed in the kidney, is significantly correlated with the development and progression of CKD and its complications. Here, we discuss in detail the role and pathophysiological implications of klotho in ion disorders, the inflammation response, vascular calcification, mineral bone disorders, and renal fibrosis in CKD. Based on the pathogenic mechanism of klotho deficiency and klotho decline in urine early in CKD stage 2 and even earlier in CKD stage 1, it is not difficult to understand that soluble klotho can serve as an early and sensitive marker of CKD. Moreover, the prevention of klotho decline by several mechanisms can attenuate renal injuries, retard CKD progression, ameliorate extrarenal complications, and improve renal function. In this review, we focus on the functions and pathophysiological implications of klotho in CKD and its extrarenal complications as well as its potential applications as a diagnostic and/or prognostic biomarker for CKD and as a novel treatment strategy to improve and decrease the burden of comorbidity in CKD.http://link.springer.com/article/10.1186/s12882-018-1094-zChronic kidney diseaseExtrarenal complicationsKlotho functionsPathogenic mechanismPotential applications |
| spellingShingle | Di Zou Wen Wu Yan He Sichao Ma Ji Gao The role of klotho in chronic kidney disease BMC Nephrology Chronic kidney disease Extrarenal complications Klotho functions Pathogenic mechanism Potential applications |
| title | The role of klotho in chronic kidney disease |
| title_full | The role of klotho in chronic kidney disease |
| title_fullStr | The role of klotho in chronic kidney disease |
| title_full_unstemmed | The role of klotho in chronic kidney disease |
| title_short | The role of klotho in chronic kidney disease |
| title_sort | role of klotho in chronic kidney disease |
| topic | Chronic kidney disease Extrarenal complications Klotho functions Pathogenic mechanism Potential applications |
| url | http://link.springer.com/article/10.1186/s12882-018-1094-z |
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