Interleukin-1-related activity and hypocretin-1 in cerebrospinal fluid contribute to fatigue in primary Sjögren’s syndrome

Interleukin-1-related activity and hypocretin-1 in cerebrospinal fluid contribute to fatigue in primary Sjögren’s syndrome

Abstract Background Fatigue is a common and sometimes debilitating phenomenon in primary Sjögren’s syndrome (pSS) and other chronic inflammatory diseases. We aimed to investigate how IL-1 β-related molecules and the neuropeptide hypocretin-1 (Hcrt1), a regulator of wakefulness, influence fatigue. Me...

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Bibliographic Details
Main Authors: Kjetil Bårdsen, Cato Brede, Ingeborg Kvivik, Jan Terje Kvaløy, Kristin Jonsdottir, Anne Bolette Tjensvoll, Peter Ruoff, Roald Omdal
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Neuroinflammation
Subjects:
Innate immunity
Cytokines
Sjögren’s syndrome
Fatigue
Hypocretin
Online Access:http://link.springer.com/article/10.1186/s12974-019-1502-8

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