Changes in expression of estrogen-regulatory genes in malignancy uterine tissues
We investigated the relative expression of genes responsible for the estrogen reception and metabolism - CYP1A 1, CYP1A 2, CYP1B 1, CYP19A, ESR1, ESR2, GPER, STS, SULT1A and SULT1E1 - by real-time PCR in tumor and conditionally healthy uterine tissues of 27 female patients in Southern Russia aged 38...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
2016-04-01
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| Series: | Кубанский научный медицинский вестник |
| Subjects: | |
| Online Access: | https://ksma.elpub.ru/jour/article/view/490 |
| _version_ | 1797295550784077824 |
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| author | O. I. Kit D. I. Vodolazhsky D. S. Kutilin T. I. Moiseenko I. S. Nikitin E. M. Frantsiyants |
| author_facet | O. I. Kit D. I. Vodolazhsky D. S. Kutilin T. I. Moiseenko I. S. Nikitin E. M. Frantsiyants |
| author_sort | O. I. Kit |
| collection | DOAJ |
| description | We investigated the relative expression of genes responsible for the estrogen reception and metabolism - CYP1A 1, CYP1A 2, CYP1B 1, CYP19A, ESR1, ESR2, GPER, STS, SULT1A and SULT1E1 - by real-time PCR in tumor and conditionally healthy uterine tissues of 27 female patients in Southern Russia aged 38-72 years with histologically confirmed diagnosis of uterine cancer. It is found that transcription activity of these genes during malignancy of uterine tissues depends of female patients age and the stage of tumor cells differentiation. It is potentially allow to use investigated genes as biomarkers of uterine tissues malignancy with considering age features of female patients and stages of cancer process development. |
| first_indexed | 2024-03-07T21:49:35Z |
| format | Article |
| id | doaj.art-7ff414f95b3940a8a6970104de0d4129 |
| institution | Directory Open Access Journal |
| issn | 1608-6228 2541-9544 |
| language | Russian |
| last_indexed | 2024-03-07T21:49:35Z |
| publishDate | 2016-04-01 |
| publisher | Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” |
| record_format | Article |
| series | Кубанский научный медицинский вестник |
| spelling | doaj.art-7ff414f95b3940a8a6970104de0d41292024-02-25T10:57:17ZrusMinistry of Healthcare of the Russian Federation. “Kuban State Medical University”Кубанский научный медицинский вестник1608-62282541-95442016-04-012849010.25207/1608-6228-2016-2-84-90490Changes in expression of estrogen-regulatory genes in malignancy uterine tissuesO. I. Kit0D. I. Vodolazhsky1D. S. Kutilin2T. I. Moiseenko3I. S. Nikitin4E. M. Frantsiyants5federal state budgetary institution «Rostov cancer research institute» the Ministry of health of the Russian Federationfederal state budgetary institution «Rostov cancer research institute» the Ministry of health of the Russian Federationfederal state budgetary institution «Rostov cancer research institute» the Ministry of health of the Russian Federationfederal state budgetary institution «Rostov cancer research institute» the Ministry of health of the Russian Federationfederal state budgetary institution «Rostov cancer research institute» the Ministry of health of the Russian Federationfederal state budgetary institution «Rostov cancer research institute» the Ministry of health of the Russian FederationWe investigated the relative expression of genes responsible for the estrogen reception and metabolism - CYP1A 1, CYP1A 2, CYP1B 1, CYP19A, ESR1, ESR2, GPER, STS, SULT1A and SULT1E1 - by real-time PCR in tumor and conditionally healthy uterine tissues of 27 female patients in Southern Russia aged 38-72 years with histologically confirmed diagnosis of uterine cancer. It is found that transcription activity of these genes during malignancy of uterine tissues depends of female patients age and the stage of tumor cells differentiation. It is potentially allow to use investigated genes as biomarkers of uterine tissues malignancy with considering age features of female patients and stages of cancer process development.https://ksma.elpub.ru/jour/article/view/490экспрессия геноврак тела маткиметаболизм эстрогеновgene expressionuterine cancerestrogen metabolism |
| spellingShingle | O. I. Kit D. I. Vodolazhsky D. S. Kutilin T. I. Moiseenko I. S. Nikitin E. M. Frantsiyants Changes in expression of estrogen-regulatory genes in malignancy uterine tissues Кубанский научный медицинский вестник экспрессия генов рак тела матки метаболизм эстрогенов gene expression uterine cancer estrogen metabolism |
| title | Changes in expression of estrogen-regulatory genes in malignancy uterine tissues |
| title_full | Changes in expression of estrogen-regulatory genes in malignancy uterine tissues |
| title_fullStr | Changes in expression of estrogen-regulatory genes in malignancy uterine tissues |
| title_full_unstemmed | Changes in expression of estrogen-regulatory genes in malignancy uterine tissues |
| title_short | Changes in expression of estrogen-regulatory genes in malignancy uterine tissues |
| title_sort | changes in expression of estrogen regulatory genes in malignancy uterine tissues |
| topic | экспрессия генов рак тела матки метаболизм эстрогенов gene expression uterine cancer estrogen metabolism |
| url | https://ksma.elpub.ru/jour/article/view/490 |
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