Predicting synthetic lethal interactions using conserved patterns in protein interaction networks.

Predicting synthetic lethal interactions using conserved patterns in protein interaction networks.

In response to a need for improved treatments, a number of promising novel targeted cancer therapies are being developed that exploit human synthetic lethal interactions. This is facilitating personalised medicine strategies in cancers where specific tumour suppressors have become inactivated. Mainl...

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Bibliografiske detaljer
Main Authors: Graeme Benstead-Hume, Xiangrong Chen, Suzanna R Hopkins, Karen A Lane, Jessica A Downs, Frances M G Pearl
Format: Article
Sprog:English
Udgivet: Public Library of Science (PLoS) 2019-04-01
Serier:PLoS Computational Biology
Online adgang:http://europepmc.org/articles/PMC6488098?pdf=render

Internet

http://europepmc.org/articles/PMC6488098?pdf=render

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