Kaempferol: A Review of Current Evidence of Its Antiviral Potential
Kaempferol and its derivatives are flavonoids found in various plants, and a considerable number of these have been used in various medical applications worldwide. Kaempferol and its compounds have well-known antioxidant, anti-inflammatory and antimicrobial properties among other health benefits. Ho...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/22/16299 |
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| author | Argyrios Periferakis Aristodemos-Theodoros Periferakis Lamprini Troumpata Konstantinos Periferakis Andreea-Elena Scheau Ilinca Savulescu-Fiedler Ana Caruntu Ioana Anca Badarau Constantin Caruntu Cristian Scheau |
| author_facet | Argyrios Periferakis Aristodemos-Theodoros Periferakis Lamprini Troumpata Konstantinos Periferakis Andreea-Elena Scheau Ilinca Savulescu-Fiedler Ana Caruntu Ioana Anca Badarau Constantin Caruntu Cristian Scheau |
| author_sort | Argyrios Periferakis |
| collection | DOAJ |
| description | Kaempferol and its derivatives are flavonoids found in various plants, and a considerable number of these have been used in various medical applications worldwide. Kaempferol and its compounds have well-known antioxidant, anti-inflammatory and antimicrobial properties among other health benefits. However, the antiviral properties of kaempferol are notable, and there is a significant number of experimental studies on this topic. Kaempferol compounds were effective against DNA viruses such as hepatitis B virus, viruses of the alphaherpesvirinae family, African swine fever virus, and pseudorabies virus; they were also effective against RNA viruses, namely feline SARS coronavirus, dengue fever virus, Japanese encephalitis virus, influenza virus, enterovirus 71, poliovirus, respiratory syncytial virus, human immunodeficiency virus, calicivirus, and chikungunya virus. On the other hand, no effectiveness against murine norovirus and hepatitis A virus could be determined. The antiviral action mechanisms of kaempferol compounds are various, such as the inhibition of viral polymerases and of viral attachment and entry into host cells. Future research should be focused on further elucidating the antiviral properties of kaempferol compounds from different plants and assessing their potential use to complement the action of antiviral drugs. |
| first_indexed | 2024-03-09T16:46:01Z |
| format | Article |
| id | doaj.art-7ff6139271374964b33391d527397177 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T16:46:01Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7ff6139271374964b33391d5273971772023-11-24T14:47:03ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-11-0124221629910.3390/ijms242216299Kaempferol: A Review of Current Evidence of Its Antiviral PotentialArgyrios Periferakis0Aristodemos-Theodoros Periferakis1Lamprini Troumpata2Konstantinos Periferakis3Andreea-Elena Scheau4Ilinca Savulescu-Fiedler5Ana Caruntu6Ioana Anca Badarau7Constantin Caruntu8Cristian Scheau9Department of Physiology, The “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Physiology, The “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Physiology, The “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaAkadimia of Ancient Greek and Traditional Chinese Medicine, 16675 Athens, GreeceDepartment of Radiology and Medical Imaging, Fundeni Clinical Institute, 022328 Bucharest, RomaniaDepartment of Internal Medicine, The “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Oral and Maxillofacial Surgery, “Carol Davila” Central Military Emergency Hospital, 010825 Bucharest, RomaniaDepartment of Physiology, The “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Physiology, The “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Physiology, The “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaKaempferol and its derivatives are flavonoids found in various plants, and a considerable number of these have been used in various medical applications worldwide. Kaempferol and its compounds have well-known antioxidant, anti-inflammatory and antimicrobial properties among other health benefits. However, the antiviral properties of kaempferol are notable, and there is a significant number of experimental studies on this topic. Kaempferol compounds were effective against DNA viruses such as hepatitis B virus, viruses of the alphaherpesvirinae family, African swine fever virus, and pseudorabies virus; they were also effective against RNA viruses, namely feline SARS coronavirus, dengue fever virus, Japanese encephalitis virus, influenza virus, enterovirus 71, poliovirus, respiratory syncytial virus, human immunodeficiency virus, calicivirus, and chikungunya virus. On the other hand, no effectiveness against murine norovirus and hepatitis A virus could be determined. The antiviral action mechanisms of kaempferol compounds are various, such as the inhibition of viral polymerases and of viral attachment and entry into host cells. Future research should be focused on further elucidating the antiviral properties of kaempferol compounds from different plants and assessing their potential use to complement the action of antiviral drugs.https://www.mdpi.com/1422-0067/24/22/16299kaempferolkaempferol derivativesantiviral actionsphysiopathologytraditional medicineethnobotany |
| spellingShingle | Argyrios Periferakis Aristodemos-Theodoros Periferakis Lamprini Troumpata Konstantinos Periferakis Andreea-Elena Scheau Ilinca Savulescu-Fiedler Ana Caruntu Ioana Anca Badarau Constantin Caruntu Cristian Scheau Kaempferol: A Review of Current Evidence of Its Antiviral Potential International Journal of Molecular Sciences kaempferol kaempferol derivatives antiviral actions physiopathology traditional medicine ethnobotany |
| title | Kaempferol: A Review of Current Evidence of Its Antiviral Potential |
| title_full | Kaempferol: A Review of Current Evidence of Its Antiviral Potential |
| title_fullStr | Kaempferol: A Review of Current Evidence of Its Antiviral Potential |
| title_full_unstemmed | Kaempferol: A Review of Current Evidence of Its Antiviral Potential |
| title_short | Kaempferol: A Review of Current Evidence of Its Antiviral Potential |
| title_sort | kaempferol a review of current evidence of its antiviral potential |
| topic | kaempferol kaempferol derivatives antiviral actions physiopathology traditional medicine ethnobotany |
| url | https://www.mdpi.com/1422-0067/24/22/16299 |
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