Variant proteins stimulate more IgM+ GC B-cells revealing a mechanism of cross-reactive recognition by antibody memory

Variant proteins stimulate more IgM+ GC B-cells revealing a mechanism of cross-reactive recognition by antibody memory

Vaccines induce memory B-cells that provide high affinity secondary antibody responses to identical antigens. Memory B-cells can also re-instigate affinity maturation, but how this happens against antigenic variants is poorly understood despite its potential impact on driving broadly protective immu...

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Bibliographic Details
Main Authors: Bronwen R Burton, Richard K Tennant, John Love, Richard W Titball, David C Wraith, Harry N White
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-05-01
Series:eLife
Subjects:
antibody memory
Dengue virus
B-cell
antibody cross-reaction
Online Access:https://elifesciences.org/articles/26832

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