Problems of primary T-cell lymphoma of the thyroid gland -A case report
<p>Abstract</p> <p>In the following report we discuss a very rare case of malignant T-cell lymphoma of the thyroid gland that developed in a 70-year-old woman with a past history of hypothyroidism due to chronic thyroiditis. The chief complaint was a rapidly growing neck mass. CT a...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-04-01
|
| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | http://www.wjso.com/content/10/1/58 |
| _version_ | 1818835897059115008 |
|---|---|
| author | Yokoyama Junkichi Ito Shin Ohba Shinichi Fujimaki Mitsuhisa Sato Eriko Komatsu Norio Ikeda Katsuhisa Hanaguri Makoto |
| author_facet | Yokoyama Junkichi Ito Shin Ohba Shinichi Fujimaki Mitsuhisa Sato Eriko Komatsu Norio Ikeda Katsuhisa Hanaguri Makoto |
| author_sort | Yokoyama Junkichi |
| collection | DOAJ |
| description | <p>Abstract</p> <p>In the following report we discuss a very rare case of malignant T-cell lymphoma of the thyroid gland that developed in a 70-year-old woman with a past history of hypothyroidism due to chronic thyroiditis. The chief complaint was a rapidly growing neck mass. CT and ultrasonographic examination revealed a diffuse large thyroid gland without a nodule extending up to 13 cm. Although presence of abnormal lymphoid cells in the peripheral blood was not found, the sIL-2 Receptor antibody and thyroglobulin measured as high as 970 U/ml and 600 ng/mL respectively. Fine needle aspiration cytology diagnosed chronic thyroiditis. A preoperative diagnosis of suspicious malignant lymphoma of the thyroid gland accompanied by Hashimoto’s thyroiditis was made, and a right hemithyroidectomy was performed to definite diagnosis. Histological examination revealed diffuse small lymphocytic infiltration in the thyroid gland associated with Hashimoto’s thyroiditis. Immunohistochemical examination showed that the small lymphocytes were positive for T-cell markers with CD3 and CD45RO. The pathological diagnosis was chronic thyroiditis with atypical lymphocytes infiltration. However, Southern blot analysis of tumor specimens revealed only a monoclonal T-cell receptor gene rearrangement. Finally, peripheral T cell lymphoma was diagnosed. Therefore, the left hemithyroidectomy was also performed one month later. No adjuvant therapy was performed due to the tumor stage and its subtype. The patient is well with no recurrence or metastasis 22 months after the surgical removal of the thyroid. As malignant T-cell lymphoma of the thyroid gland with Hashimoto’s thyroiditis was difficult to diagnose, gene rearrangement examination needed to be performed concurrently.</p> |
| first_indexed | 2024-12-19T02:58:00Z |
| format | Article |
| id | doaj.art-7ff66b3ff4814ef28bfed44692b81751 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-19T02:58:00Z |
| publishDate | 2012-04-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-7ff66b3ff4814ef28bfed44692b817512022-12-21T20:38:18ZengBMCWorld Journal of Surgical Oncology1477-78192012-04-011015810.1186/1477-7819-10-58Problems of primary T-cell lymphoma of the thyroid gland -A case reportYokoyama JunkichiIto ShinOhba ShinichiFujimaki MitsuhisaSato ErikoKomatsu NorioIkeda KatsuhisaHanaguri Makoto<p>Abstract</p> <p>In the following report we discuss a very rare case of malignant T-cell lymphoma of the thyroid gland that developed in a 70-year-old woman with a past history of hypothyroidism due to chronic thyroiditis. The chief complaint was a rapidly growing neck mass. CT and ultrasonographic examination revealed a diffuse large thyroid gland without a nodule extending up to 13 cm. Although presence of abnormal lymphoid cells in the peripheral blood was not found, the sIL-2 Receptor antibody and thyroglobulin measured as high as 970 U/ml and 600 ng/mL respectively. Fine needle aspiration cytology diagnosed chronic thyroiditis. A preoperative diagnosis of suspicious malignant lymphoma of the thyroid gland accompanied by Hashimoto’s thyroiditis was made, and a right hemithyroidectomy was performed to definite diagnosis. Histological examination revealed diffuse small lymphocytic infiltration in the thyroid gland associated with Hashimoto’s thyroiditis. Immunohistochemical examination showed that the small lymphocytes were positive for T-cell markers with CD3 and CD45RO. The pathological diagnosis was chronic thyroiditis with atypical lymphocytes infiltration. However, Southern blot analysis of tumor specimens revealed only a monoclonal T-cell receptor gene rearrangement. Finally, peripheral T cell lymphoma was diagnosed. Therefore, the left hemithyroidectomy was also performed one month later. No adjuvant therapy was performed due to the tumor stage and its subtype. The patient is well with no recurrence or metastasis 22 months after the surgical removal of the thyroid. As malignant T-cell lymphoma of the thyroid gland with Hashimoto’s thyroiditis was difficult to diagnose, gene rearrangement examination needed to be performed concurrently.</p>http://www.wjso.com/content/10/1/58Peripheral T-cell lymphomaThyroidHashimoto’s thyroiditisMolecular diagnosisGene rearrangement |
| spellingShingle | Yokoyama Junkichi Ito Shin Ohba Shinichi Fujimaki Mitsuhisa Sato Eriko Komatsu Norio Ikeda Katsuhisa Hanaguri Makoto Problems of primary T-cell lymphoma of the thyroid gland -A case report World Journal of Surgical Oncology Peripheral T-cell lymphoma Thyroid Hashimoto’s thyroiditis Molecular diagnosis Gene rearrangement |
| title | Problems of primary T-cell lymphoma of the thyroid gland -A case report |
| title_full | Problems of primary T-cell lymphoma of the thyroid gland -A case report |
| title_fullStr | Problems of primary T-cell lymphoma of the thyroid gland -A case report |
| title_full_unstemmed | Problems of primary T-cell lymphoma of the thyroid gland -A case report |
| title_short | Problems of primary T-cell lymphoma of the thyroid gland -A case report |
| title_sort | problems of primary t cell lymphoma of the thyroid gland a case report |
| topic | Peripheral T-cell lymphoma Thyroid Hashimoto’s thyroiditis Molecular diagnosis Gene rearrangement |
| url | http://www.wjso.com/content/10/1/58 |
| work_keys_str_mv | AT yokoyamajunkichi problemsofprimarytcelllymphomaofthethyroidglandacasereport AT itoshin problemsofprimarytcelllymphomaofthethyroidglandacasereport AT ohbashinichi problemsofprimarytcelllymphomaofthethyroidglandacasereport AT fujimakimitsuhisa problemsofprimarytcelllymphomaofthethyroidglandacasereport AT satoeriko problemsofprimarytcelllymphomaofthethyroidglandacasereport AT komatsunorio problemsofprimarytcelllymphomaofthethyroidglandacasereport AT ikedakatsuhisa problemsofprimarytcelllymphomaofthethyroidglandacasereport AT hanagurimakoto problemsofprimarytcelllymphomaofthethyroidglandacasereport |