A Novel Controllable Hydrogen Sulfide-Releasing Molecule Protects Human Skin Keratinocytes Against Methylglyoxal-Induced Injury and Dysfunction

A Novel Controllable Hydrogen Sulfide-Releasing Molecule Protects Human Skin Keratinocytes Against Methylglyoxal-Induced Injury and Dysfunction

Background/Aim: Delayed wound healing is a common skin complication of diabetes, which is associated with keratinocyte injury and dysfunction. Levels of methylglyoxal (MGO), an α-dicarbonyl compound, are elevated in diabetic skin tissue and plasma, while levels of hydrogen sulfide (H2S), a critical...

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Bibliographic Details
Main Authors: Chun-tao Yang, Yu Zhao, Ming Xian, Jian-hua Li, Qi Dong, Hong-bo Bai, Ji-de Xu, Mei-fen Zhang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
Methylglyoxal
Delayed wound healing
Diabetes mellitus
Hydrogen sulfide
Keratinocyte
Online Access:http://www.karger.com/Article/FullText/366339

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