Apolipoprotein A5 ameliorates MCT induced pulmonary hypertension by inhibiting ER stress in a GRP78 dependent mechanism

Apolipoprotein A5 ameliorates MCT induced pulmonary hypertension by inhibiting ER stress in a GRP78 dependent mechanism

Abstract Background Pulmonary arterial hypertension (PAH) is a chronic, progressive lung vascular disease accompanied by elevated pulmonary vascular pressure and resistance, and it is characterized by increased pulmonary artery smooth muscle cell (PASMC) proliferation. Apolipoprotein A5 (ApoA5) impr...

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Bibliographic Details
Main Authors: Jingyuan Chen, Jun Luo, Haihua Qiu, Yi Tang, Xiaojie Yang, Yusi Chen, Zilu Li, Jiang Li
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Lipids in Health and Disease
Subjects:
Pulmonary arterial hypertension
Apolipoprotein A5
Endoplasmic reticulum stress
Glucose- regulated protein 78
Online Access:https://doi.org/10.1186/s12944-022-01680-4

Internet

https://doi.org/10.1186/s12944-022-01680-4

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