Sigma-1 Receptor Changes Observed in Chronic Pelvic Pain Patients: A Pilot PET/MRI Study
Introduction: Chronic pelvic pain is a highly prevalent pain condition among women, but identifying the exact cause of pelvic pain remains a significant diagnostic challenge. In this study, we explored a new diagnostic approach with PET/MRI of the sigma-1 receptor, a chaperone protein modulating ion...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Pain Research |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpain.2021.711748/full |
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| author | Daehyun Yoon Angela M. Fast Peter Cipriano Bin Shen Jessa B. Castillo Christopher R. McCurdy Carina Mari Aparici Deirdre Lum Sandip Biswal |
| author_facet | Daehyun Yoon Angela M. Fast Peter Cipriano Bin Shen Jessa B. Castillo Christopher R. McCurdy Carina Mari Aparici Deirdre Lum Sandip Biswal |
| author_sort | Daehyun Yoon |
| collection | DOAJ |
| description | Introduction: Chronic pelvic pain is a highly prevalent pain condition among women, but identifying the exact cause of pelvic pain remains a significant diagnostic challenge. In this study, we explored a new diagnostic approach with PET/MRI of the sigma-1 receptor, a chaperone protein modulating ion channels for activating nociceptive processes.Methods: Our approach is implemented by a simultaneous PET/MRI scan with a novel radioligand [18F]FTC-146, which is highly specific to the sigma-1 receptor. We recruited 5 chronic pelvic pain patients and 5 healthy volunteers and compared our PET/MRI findings between these two groups.Results: All five patients showed abnormally increased radioligand uptake on PET compared to healthy controls at various organs, including the uterus, vagina, pelvic bowel, gluteus maximus muscle, and liver. However, on MRI, only 2 patients showed abnormalities that could be potentially associated with the pain symptoms. For a subset of patients, the association of pain and the abnormally increased radioligand uptake was further validated by successful pain relief outcomes following surgery or trigger point injections to the identified abnormalities.Conclusion: In this preliminary study, sigma-1 receptor PET/MRI demonstrated potential for identifying abnormalities associated with chronic pelvic pain. Future studies will need to correlate samples with imaging findings to further validate the correlation between S1R distribution and pathologies of chronic pelvic pain.Trial Registration: The clinical trial registration date is June 2, 2018, and the registration number of the study is NCT03195270 (https://clinicaltrials.gov/ct2/show/NCT03556137). |
| first_indexed | 2024-12-21T04:31:11Z |
| format | Article |
| id | doaj.art-7ff8532d0c0c49e7a628a33af433aea6 |
| institution | Directory Open Access Journal |
| issn | 2673-561X |
| language | English |
| last_indexed | 2024-12-21T04:31:11Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pain Research |
| spelling | doaj.art-7ff8532d0c0c49e7a628a33af433aea62022-12-21T19:15:56ZengFrontiers Media S.A.Frontiers in Pain Research2673-561X2021-10-01210.3389/fpain.2021.711748711748Sigma-1 Receptor Changes Observed in Chronic Pelvic Pain Patients: A Pilot PET/MRI StudyDaehyun Yoon0Angela M. Fast1Peter Cipriano2Bin Shen3Jessa B. Castillo4Christopher R. McCurdy5Carina Mari Aparici6Deirdre Lum7Sandip Biswal8Department of Radiology, School of Medicine, Stanford University, Stanford, CA, United StatesDiagnostic, Molecular and Interventional Radiology, The Mount Sinai Hospital, New York, NY, United StatesDepartment of Radiology, School of Medicine, Stanford University, Stanford, CA, United StatesDepartment of Radiology, School of Medicine, Stanford University, Stanford, CA, United StatesDepartment of Radiology, School of Medicine, Stanford University, Stanford, CA, United StatesDepartment of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, United StatesDepartment of Radiology, School of Medicine, Stanford University, Stanford, CA, United StatesDepartment of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA, United StatesDepartment of Radiology, School of Medicine, Stanford University, Stanford, CA, United StatesIntroduction: Chronic pelvic pain is a highly prevalent pain condition among women, but identifying the exact cause of pelvic pain remains a significant diagnostic challenge. In this study, we explored a new diagnostic approach with PET/MRI of the sigma-1 receptor, a chaperone protein modulating ion channels for activating nociceptive processes.Methods: Our approach is implemented by a simultaneous PET/MRI scan with a novel radioligand [18F]FTC-146, which is highly specific to the sigma-1 receptor. We recruited 5 chronic pelvic pain patients and 5 healthy volunteers and compared our PET/MRI findings between these two groups.Results: All five patients showed abnormally increased radioligand uptake on PET compared to healthy controls at various organs, including the uterus, vagina, pelvic bowel, gluteus maximus muscle, and liver. However, on MRI, only 2 patients showed abnormalities that could be potentially associated with the pain symptoms. For a subset of patients, the association of pain and the abnormally increased radioligand uptake was further validated by successful pain relief outcomes following surgery or trigger point injections to the identified abnormalities.Conclusion: In this preliminary study, sigma-1 receptor PET/MRI demonstrated potential for identifying abnormalities associated with chronic pelvic pain. Future studies will need to correlate samples with imaging findings to further validate the correlation between S1R distribution and pathologies of chronic pelvic pain.Trial Registration: The clinical trial registration date is June 2, 2018, and the registration number of the study is NCT03195270 (https://clinicaltrials.gov/ct2/show/NCT03556137).https://www.frontiersin.org/articles/10.3389/fpain.2021.711748/fullchronic pelvic painsigma-1 receptorpositron emission tomographymagnetic resonance imagingPET/MRI |
| spellingShingle | Daehyun Yoon Angela M. Fast Peter Cipriano Bin Shen Jessa B. Castillo Christopher R. McCurdy Carina Mari Aparici Deirdre Lum Sandip Biswal Sigma-1 Receptor Changes Observed in Chronic Pelvic Pain Patients: A Pilot PET/MRI Study Frontiers in Pain Research chronic pelvic pain sigma-1 receptor positron emission tomography magnetic resonance imaging PET/MRI |
| title | Sigma-1 Receptor Changes Observed in Chronic Pelvic Pain Patients: A Pilot PET/MRI Study |
| title_full | Sigma-1 Receptor Changes Observed in Chronic Pelvic Pain Patients: A Pilot PET/MRI Study |
| title_fullStr | Sigma-1 Receptor Changes Observed in Chronic Pelvic Pain Patients: A Pilot PET/MRI Study |
| title_full_unstemmed | Sigma-1 Receptor Changes Observed in Chronic Pelvic Pain Patients: A Pilot PET/MRI Study |
| title_short | Sigma-1 Receptor Changes Observed in Chronic Pelvic Pain Patients: A Pilot PET/MRI Study |
| title_sort | sigma 1 receptor changes observed in chronic pelvic pain patients a pilot pet mri study |
| topic | chronic pelvic pain sigma-1 receptor positron emission tomography magnetic resonance imaging PET/MRI |
| url | https://www.frontiersin.org/articles/10.3389/fpain.2021.711748/full |
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