Isolated testicular tuberculosis with ethambutol cutaneous toxicity: A combination of two rare entities

Tuberculosis (TB) is an infection that can affect any organ, affecting mainly the lungs. Isolated testicular TB is very rare. Six months of a multiple drug scheme is the mainstay of TB treatment. Adverse reaction to anti-TB chemotherapy is frequent and affects the course of the therapy, leading some...

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Main Authors: Flávio Godinho Pereira, Mariana da Silva Leal, Susana Cavadas, Inês Ladeira
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:International Journal of Mycobacteriology
Subjects:
Online Access:http://www.ijmyco.org/article.asp?issn=2212-5531;year=2020;volume=9;issue=3;spage=322;epage=324;aulast=Pereira
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author Flávio Godinho Pereira
Mariana da Silva Leal
Susana Cavadas
Inês Ladeira
author_facet Flávio Godinho Pereira
Mariana da Silva Leal
Susana Cavadas
Inês Ladeira
author_sort Flávio Godinho Pereira
collection DOAJ
description Tuberculosis (TB) is an infection that can affect any organ, affecting mainly the lungs. Isolated testicular TB is very rare. Six months of a multiple drug scheme is the mainstay of TB treatment. Adverse reaction to anti-TB chemotherapy is frequent and affects the course of the therapy, leading sometimes to discontinuation of drugs. Ethambutol optic nerve toxicity is frequent. However, severe cutaneous and anaphylactic reactions associated to ethambutol are very rare. We present the case of an immunocompetent patient presenting with isolated testicular TB that exhibited a severe cutaneous and anaphylactic reaction to ethambutol during the consolidation treatment phase. This led to exhaustive etiologic study and treatment modification.
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spelling doaj.art-7ff9646c2340496eab2e594ab7b545132022-12-22T01:07:50ZengWolters Kluwer Medknow PublicationsInternational Journal of Mycobacteriology2212-55312212-554X2020-01-019332232410.4103/ijmy.ijmy_114_20Isolated testicular tuberculosis with ethambutol cutaneous toxicity: A combination of two rare entitiesFlávio Godinho PereiraMariana da Silva LealSusana CavadasInês LadeiraTuberculosis (TB) is an infection that can affect any organ, affecting mainly the lungs. Isolated testicular TB is very rare. Six months of a multiple drug scheme is the mainstay of TB treatment. Adverse reaction to anti-TB chemotherapy is frequent and affects the course of the therapy, leading sometimes to discontinuation of drugs. Ethambutol optic nerve toxicity is frequent. However, severe cutaneous and anaphylactic reactions associated to ethambutol are very rare. We present the case of an immunocompetent patient presenting with isolated testicular TB that exhibited a severe cutaneous and anaphylactic reaction to ethambutol during the consolidation treatment phase. This led to exhaustive etiologic study and treatment modification.http://www.ijmyco.org/article.asp?issn=2212-5531;year=2020;volume=9;issue=3;spage=322;epage=324;aulast=Pereiracutaneous toxicityethambutolextrapulmonary tuberculosistesticular tuberculosis
spellingShingle Flávio Godinho Pereira
Mariana da Silva Leal
Susana Cavadas
Inês Ladeira
Isolated testicular tuberculosis with ethambutol cutaneous toxicity: A combination of two rare entities
International Journal of Mycobacteriology
cutaneous toxicity
ethambutol
extrapulmonary tuberculosis
testicular tuberculosis
title Isolated testicular tuberculosis with ethambutol cutaneous toxicity: A combination of two rare entities
title_full Isolated testicular tuberculosis with ethambutol cutaneous toxicity: A combination of two rare entities
title_fullStr Isolated testicular tuberculosis with ethambutol cutaneous toxicity: A combination of two rare entities
title_full_unstemmed Isolated testicular tuberculosis with ethambutol cutaneous toxicity: A combination of two rare entities
title_short Isolated testicular tuberculosis with ethambutol cutaneous toxicity: A combination of two rare entities
title_sort isolated testicular tuberculosis with ethambutol cutaneous toxicity a combination of two rare entities
topic cutaneous toxicity
ethambutol
extrapulmonary tuberculosis
testicular tuberculosis
url http://www.ijmyco.org/article.asp?issn=2212-5531;year=2020;volume=9;issue=3;spage=322;epage=324;aulast=Pereira
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AT marianadasilvaleal isolatedtesticulartuberculosiswithethambutolcutaneoustoxicityacombinationoftworareentities
AT susanacavadas isolatedtesticulartuberculosiswithethambutolcutaneoustoxicityacombinationoftworareentities
AT inesladeira isolatedtesticulartuberculosiswithethambutolcutaneoustoxicityacombinationoftworareentities