Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes

Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes

The spike protein of coronaviruses (S-protein) is an envelope-anchored trimeric type I transmembrane glycoprotein that mediates receptor binding and the fusion of the viral and host cell membranes. Here the authors report the conformational states of HCoV-229E S trimer and observe the conformational...

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Bibliographic Details
Main Authors: Xiyong Song, Yuejun Shi, Wei Ding, Tongxin Niu, Limeng Sun, Yubei Tan, Yong Chen, Jiale Shi, Qiqi Xiong, Xiaojun Huang, Shaobo Xiao, Yanping Zhu, Chongyun Cheng, Zhen F. Fu, Zhi-Jie Liu, Guiqing Peng
Format: Article
Language:English
Published: Nature Portfolio 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20401-y

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