Involvement of RIG-I Pathway in Neurotropic Virus-Induced Acute Flaccid Paralysis and Subsequent Spinal Motor Neuron Death

Involvement of RIG-I Pathway in Neurotropic Virus-Induced Acute Flaccid Paralysis and Subsequent Spinal Motor Neuron Death

ABSTRACT Poliomyelitis-like illness is a common clinical manifestation of neurotropic viral infections. Functional loss and death of motor neurons often lead to reduced muscle tone and paralysis, causing persistent motor sequelae among disease survivors. Despite several reports demonstrating the mol...

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Bibliographic Details
Main Authors: Meenakshi Bhaskar, Sriparna Mukherjee, Anirban Basu
Format: Article
Language:English
Published: American Society for Microbiology 2021-12-01
Series:mBio
Subjects:
acute flaccid paralysis
neurotropic virus
motor neuron
cell death
pattern-recognition receptor RIG-I
Online Access:https://journals.asm.org/doi/10.1128/mBio.02712-21

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